Yung-Chi Cheng

TL;DR: Data indicate that end-organ disease in MRL/Fas(lpr) mice responds differentially to NF-kappaB inhibitor and may potentially be beneficial in the treatment of inflammatory skin disease in SLE.

TL;DR: There appears to be a concentration-related correlation between the increase of lactic acid and the extent of mtDNA inhibition for the compounds examined, and the highest ratios indicating the greatest potential for delayed toxicity.

TL;DR: Six 4 beta-arylamino derivatives of 4'-O-demethylepipodophyllotoxin were examined for inhibitory activity against human DNA topoisomerase II and tubulin polymerization, their ability to generate protein-linked DNA breaks in cells, and their cytotoxicity toward the KB cell line and its VP-16- and vincristine-resistant variants.

TL;DR: Conjugation afforded cleavable complex-forming topoisomerase inhibitors which display dual target specificity and a broad spectrum of cytotoxic activity against drug-resistant cells.

TL;DR: Erythrocytic NDP kinase activities were high and electrophoretically heterogeneous in all species examined and patterns of nucleotide extracts of whole blood and erythrocytes in seal, eel, hagfish, dogfish, nurse shark and stingray were similar when determined by high-pressure liquid chromatography.