Y
Yushi Takahashi
Researcher at Tohoku University
Publications - 1
Citations - 24
Yushi Takahashi is an academic researcher from Tohoku University. The author has contributed to research in topics: Drug repositioning & Hsp90. The author has an hindex of 1, co-authored 1 publications receiving 10 citations.
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Geldanamycin-Derived HSP90 Inhibitors Are Synthetic Lethal with NRF2.
TL;DR: A novel synthetic lethal assay is developed, based on fluorescently labeled isogenic wild-type and Keap1 knockout cell lines, in order to screen for compounds which selectively kill cells in an NRF2-dependent manner, and identifies three compounds based on the geldanamycin scaffold which display synthetic lethality withNRF2.