Eiji Hishinuma

TL;DR: JMorp now provides four different kinds of omics data (genome, methylome, transcriptome, and metabolome), with a user-friendly web interface, which will be a useful scientific data resource on the general population for the discovery of disease biomarkers and personalized disease prevention and early diagnosis.

TL;DR: The band patterns observed in the immunoblots of blue-native gels indicated that DPD dimerization is required for enzymatic activity in DPD, suggesting that the detection of rare DPYD variants might facilitate severe adverse effect prediction of 5-FU–based chemotherapy in the Japanese population.

TL;DR: A novel synthetic lethal assay is developed, based on fluorescently labeled isogenic wild-type and Keap1 knockout cell lines, in order to screen for compounds which selectively kill cells in an NRF2-dependent manner, and identifies three compounds based on the geldanamycin scaffold which display synthetic lethality withNRF2.

TL;DR: In this paper, mass spectrometry (MSI) has been applied in pharmacological studies to predict therapeutic and adverse reactions of drugs, which is called pharmacometabolomics (PMx).

TL;DR: This is the first report of a DHP-deficient patient with DPYS compound heterozygous polymorphisms who was treated with a fluoropyrimidine, and the findings suggest that polymorphisms in the DPYS gene are pharmacogenomic markers associated with severe 5-FU toxicity in Japanese patients.