T
Takafumi Suzuki
Researcher at Tohoku University
Publications - 62
Citations - 7543
Takafumi Suzuki is an academic researcher from Tohoku University. The author has contributed to research in topics: Transcription factor & Oxidative stress. The author has an hindex of 33, co-authored 58 publications receiving 5850 citations. Previous affiliations of Takafumi Suzuki include University of Tsukuba.
Papers
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Journal ArticleDOI
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
Eri H. Kobayashi,Takafumi Suzuki,Ryo Funayama,Takeshi Nagashima,Makiko Hayashi,Hiroki Sekine,Nobuyuki Tanaka,Takashi Moriguchi,Hozumi Motohashi,Keiko Nakayama,Masayuki Yamamoto +10 more
TL;DR: It is demonstrated that Nrf2 interferes with lipopolysaccharide-induced transcriptional upregulation of proinflammatory cytokines, including IL-6 and IL-1β, and establishes a molecular basis for an NRF2-mediated anti-inflammation approach.
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Molecular basis of the Keap1–Nrf2 system
TL;DR: Cross talk between Nrf2 and other signaling pathways is identified, which provides new insights into the mechanisms by which the Keap1-Nrf2 system serves as a potent regulator of the authors' health and disease.
Journal ArticleDOI
Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth
Tsutomu Ohta,Kumiko Iijima,Mamiko Miyamoto,Izumi Nakahara,Hiroshi Tanaka,Makiko Ohtsuji,Takafumi Suzuki,Akira Kobayashi,Jun Yokota,Tokuki Sakiyama,Tatsuhiro Shibata,Masayuki Yamamoto,Setsuo Hirohashi +12 more
TL;DR: In lung cancer cells, low Keap1 activity led to nuclear localization and constitutive activation of Nrf2, which resulted in constitutive expression of cytoprotective genes encoding multidrug resistance pumps, phase II detoxifying enzymes, and antioxidative stress enzymes/proteins.
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Toward clinical application of the Keap1–Nrf2 pathway
TL;DR: Translational studies of the Keap1-Nrf2 system, from mechanistic understanding to clinical applications, are now important to improve human health.
Journal ArticleDOI
Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity.
Tae Yamamoto,Takafumi Suzuki,Akira Kobayashi,Junko Wakabayashi,Jon M. Maher,Hozumi Motohashi,Hozumi Motohashi,Masayuki Yamamoto,Masayuki Yamamoto +8 more
TL;DR: Critical roles of the cysteine residues in vivo in maintaining Keap1 function are demonstrated, such that Nrf2 is repressed under quiescent conditions and active in response to oxidants/electrophiles.