Y
Yuxiang Sun
Researcher at Texas A&M University
Publications - 115
Citations - 6415
Yuxiang Sun is an academic researcher from Texas A&M University. The author has contributed to research in topics: Ghrelin & Growth hormone secretagogue receptor. The author has an hindex of 35, co-authored 104 publications receiving 5369 citations. Previous affiliations of Yuxiang Sun include Agricultural Research Service & University of Manitoba.
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Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
TL;DR: In contrast to wild-type mice, acute treatment of Ghsr-null mice with ghrelin stimulated neither GH release nor food intake, showing that the GHSR is a biologically relevantghrelin receptor and suggesting that chronic treatment with gh Relin antagonists will have little effect on growth or appetite.
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Deletion of ghrelin impairs neither growth nor appetite.
TL;DR: The data show that ghrelin is not critically required for viability, fertility, growth, appetite, bone density, and fat deposition and not likely to be a direct regulator of leptin and insulin, and antagonists of gh Relin are unlikely to have broad utility as antiobesity agents.
Journal ArticleDOI
Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor.
Koji Toshinai,Hideki Yamaguchi,Yuxiang Sun,Roy G. Smith,Akihiro Yamanaka,Takeshi Sakurai,Yukari Date,Muhtashan S. Mondal,Takuya Shimbara,Takashi Kawagoe,Noboru Murakami,Mikiya Miyazato,Kenji Kangawa,Masamitsu Nakazato +13 more
TL;DR: Central des-acyl ghrelin may activate orexin-expressing neurons, perhaps functioning in feeding regulation through interactions with a target protein distinct from the GHS-R.
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Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice.
TL;DR: It is demonstrated that ablation of ghrelin reduces expression of Ucp2 mRNA in the pancreas, which contributes toward enhanced glucose-induced insulin secretion and insulin sensitivity, and chronically, gh Relin controls glucose homeostasis by regulating pancreatic UCP2 expression and insulinensitivity.
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Characterization of Adult Ghrelin and Ghrelin Receptor Knockout Mice under Positive and Negative Energy Balance
TL;DR: The hypothesis that the primary metabolic function of ghrelin in adult mice is to modulate glucose sensing and insulin sensitivity, rather than directly regulate energy intake and energy expenditure, is supported.