Z. Jimmy Zhou

TL;DR: It is shown that SACs make cholinergic synapses onto On-Off direction-selective ganglion cells (DSGCs) from all directions but make GABAergicsynapses onto DSGCs only from the null direction, suggesting differential, yet synergistic, roles of ACh-GABA cotransmission in motion sensitivity and direction selectivity.

TL;DR: This work manipulated the pattern of spontaneous retinal waves present during development without changing overall activity levels through the transgenic expression of β2-nicotinic acetylcholine receptors in retinal ganglion cells of mice to demonstrate that spontaneousretinal activity is not just permissive, but instructive in the emergence of eye-specific segregation and retinotopic refinement in the mouse visual system.

TL;DR: Patch-clamp recordings revealed that distal processes of starburst amacrine cells (SACs) received largely excitatory synaptic input from the receptive field center and nearly purely inhibitory inputs from the surround during both stationary and moving light stimulations.

TL;DR: It is shown that with maturation, the nicotinic synapses between starburst cells dramatically diminished, whereas the GABAergic synapses remained and changed from excitatory to inhibitory, indicating a coordinated conversion of the starburst network excitability from an early hyperexcitatory to a mature nonepileptic state.

TL;DR: A systematic investigation of the dynamics, regulation and distribution of spontaneous waves in the rabbit retina during the course of wave development prior to eye opening revealed a multistaged developmental sequence and stage‐dependent dynamics, pharmacology and regulation of spontaneous retinal Waves in the mammalian retina.