Seunghoon Lee

TL;DR: It is shown that SACs make cholinergic synapses onto On-Off direction-selective ganglion cells (DSGCs) from all directions but make GABAergicsynapses onto DSGCs only from the null direction, suggesting differential, yet synergistic, roles of ACh-GABA cotransmission in motion sensitivity and direction selectivity.

TL;DR: Patch-clamp recordings revealed that distal processes of starburst amacrine cells (SACs) received largely excitatory synaptic input from the receptive field center and nearly purely inhibitory inputs from the surround during both stationary and moving light stimulations.

TL;DR: It is shown that with maturation, the nicotinic synapses between starburst cells dramatically diminished, whereas the GABAergic synapses remained and changed from excitatory to inhibitory, indicating a coordinated conversion of the starburst network excitability from an early hyperexcitatory to a mature nonepileptic state.

TL;DR: The data suggest that myelin uptake is an early response of astrocytes in diseases with prominent myelin injury that results in recruitment of immune cells, and might be of therapeutic relevance in multiple sclerosis and other demyelinating conditions.

TL;DR: A systematic investigation of the dynamics, regulation and distribution of spontaneous waves in the rabbit retina during the course of wave development prior to eye opening revealed a multistaged developmental sequence and stage‐dependent dynamics, pharmacology and regulation of spontaneous retinal Waves in the mammalian retina.