Zahra Bahrami-Nejad

TL;DR: The mechanism of how hormone oscillations are filtered as a combination of slow and fast positive feedback centered on PPARG is identified, providing a molecular mechanism for why stress, Cushing's disease, and other conditions for which glucocorticoid secretion loses its pulsatility may lead to obesity.

TL;DR: A systematic forward genetic analysis through reporter-based screens in haploid human cells uncovered new regulatory features at most levels of canonical WNT signaling that should enable the comprehensive understanding of other signaling systems.

TL;DR: It is proposed that residual SWI/SNF complexes lacking SMARCB1 are vital determinants of drug sensitivity, not just to TOP2A-targeted agents, but to the much broader range of cancer drugs effluxed by ABCB1.

TL;DR: Using live, single-cell imaging of cell cycle progression and differentiation commitment during adipogenesis, it is shown that a rapid switch mechanism engages exclusively in G1 to trigger differentiation commitment simultaneously with permanent exit from the cell cycle.

TL;DR: A rapid switch mechanism engages exclusively in G1 to trigger a simultaneous commitment to differentiate and permanently exit from the cell cycle and the differentiation control system is able to couple mitogen and differentiation stimuli to sustain a long-term balance between terminally differentiating cells and maintaining the progenitor cell pool.