Z
Zdenek Sedlacek
Researcher at Charles University in Prague
Publications - 75
Citations - 16450
Zdenek Sedlacek is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Gene & Germline mutation. The author has an hindex of 27, co-authored 73 publications receiving 15743 citations. Previous affiliations of Zdenek Sedlacek include University of California, Irvine & Lincoln's Inn.
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Direct selection of DNA sequences conserved between species
TL;DR: A novel procedure for the selective isolation of conserved sequences which is based on hybridization of PCR-amplifiable DNA fragments from the whole genome of one species to biotinylated DNA from a genomic region of another species is described.
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Teaching a difficult topic using a problem-based concept resembling a computer game: development and evaluation of an e-learning application for medical molecular genetics.
TL;DR: An electronic teaching application that simulates the process of molecular genetic diagnostics of a hereditary disorder in a family and can be modified for training in the use of electronic information resources in other medical specialties.
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Anophthalmia, hearing loss, abnormal pituitary development and response to growth hormone therapy in three children with microdeletions of 14q22q23
Sophie Brisset,Zuzana Slamova,Petra Dusatkova,Audrey Briand-Suleau,Karen Milcent,Corinne Metay,Martina Simandlova,Zdenek Sumnik,Lucie Tosca,Lucie Tosca,Michel Goossens,Philippe Labrune,Elsa Zemankova,Jan Lebl,Gérard Tachdjian,Gérard Tachdjian,Zdenek Sedlacek +16 more
TL;DR: The pituitary hypoplasia, growth hormone deficiency and growth retardation associated with 14q22q23 microdeletions are very remarkable, and the latter appears to have an atypical response to growth hormone therapy in some of the cases.
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Analysis of genetic events in 17p13 and 9p21 regions supports predominant monoclonal origin of multifocal and recurrent bladder cancer.
Marie Trkova,Marko Babjuk,Jaroslava Dušková,Lucie Benesova-Minarikova,Viktor Soukup,J. Mareš,Marek Minarik,Zdenek Sedlacek +7 more
TL;DR: The results rather support the monoclonal model of development of highly recurrent superficial bladder TCCs, with either absence or presence of the same TP53 mutation and/or an identical LOH pattern, with the same allele lost in all tumours.
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A rare tumor and an ethical dilemma in a family with a germline TP53 mutation.
TL;DR: In this article, the authors describe a family with a history of cancer suggestive of the Li-Fraumeni syndrome (LFS), and the case illustrates ethical problems associated with early predisposition testing in LFS, and the lack of consensus on this issue in the literature.