G
Gérard Tachdjian
Researcher at French Institute of Health and Medical Research
Publications - 139
Citations - 4575
Gérard Tachdjian is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Comparative genomic hybridization & Gene. The author has an hindex of 30, co-authored 129 publications receiving 4139 citations. Previous affiliations of Gérard Tachdjian include University of Paris & University of Paris-Sud.
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Journal ArticleDOI
Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report
Philippe Menasché,Philippe Menasché,Valérie Vanneaux,Albert Hagège,Albert Hagège,Alain Bel,Bernard Cholley,Isabelle Cacciapuoti,Alexandre Parouchev,Nadine Benhamouda,Gérard Tachdjian,Lucie Tosca,Jean-Hugues Trouvin,Jean-Roch Fabreguettes,Valérie Bellamy,Romain Guillemain,Caroline Suberbielle Boissel,Eric Tartour,Eric Tartour,Michel Desnos,Michel Desnos,Jérôme Larghero,Jérôme Larghero +22 more
TL;DR: This observation demonstrates the feasibility of generating a clinical-grade population of human ESC-derived cardiac progenitors and combining it within a tissue-engineered construct.
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Transplantation of Human Embryonic Stem Cell–Derived Cardiovascular Progenitors for Severe Ischemic Left Ventricular Dysfunction
Philippe Menasché,Valérie Vanneaux,Albert Hagège,Alain Bel,Bernard Cholley,Alexandre Parouchev,Isabelle Cacciapuoti,Reem Al-Daccak,Nadine Benhamouda,Hélène Blons,Onnik Agbulut,Lucie Tosca,Jean-Hugues Trouvin,Jean-Roch Fabreguettes,Valérie Bellamy,Dominique Charron,Eric Tartour,Gérard Tachdjian,Michel Desnos,Jérôme Larghero +19 more
TL;DR: This trial demonstrates the technical feasibility of producing clinical-grade hESC-derived cardiovascular progenitors and supports their short- and medium-term safety, thereby setting the grounds for adequately powered efficacy studies.
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Risk of tumorigenicity in mesenchymal stromal cell-based therapies--bridging scientific observations and regulatory viewpoints.
Lisbeth Barkholt,Lisbeth Barkholt,Egbert Flory,Egbert Flory,Veronika Jekerle,Sophie Lucas-Samuel,Peter Ahnert,Louise Bisset,Louise Bisset,Dirk Büscher,Willem E. Fibbe,Arnaud Foussat,Marcel Kwa,Olivier Lantz,Romaldas Mačiulaitis,Romaldas Mačiulaitis,Tiina Palomäki,Christian K. Schneider,Luc Sensebé,Gérard Tachdjian,Karin Tarte,Lucie Tosca,Paula Salmikangas +22 more
TL;DR: This meeting elucidated the risk of potential tumorigenicity related to MSC-based therapies from two angles: the scientific perspective and the regulatory point of view, leading to a clearer way forward for the development of such products.
Journal ArticleDOI
Human embryonic stem cells reveal recurrent genomic instability at 20q11.21
Nathalie Lefort,Maxime Feyeux,Cécile Bas,Olivier Feraud,Annelise Bennaceur-Griscelli,Gérard Tachdjian,Marc Peschanski,Anselme L. Perrier +7 more
TL;DR: A recurrent genomic instability in the human genome is identified and an amplification of 2.5–4.6 Mb at 20q11.21, encompassing ∼23 genes in common, was detected in four cell lines of different origins, which may provide a selective advantage to hES cells in culture.
Journal ArticleDOI
Preimplantation genetic diagnosis: state of the art.
Claire Basille,René Frydman,Abdelwahab El Aly,Laetitia Hesters,Renato Fanchin,Gérard Tachdjian,Julie Steffann,Julie Steffann,M. Lelorc’h,M. Lelorc’h,Nelly Achour-Frydman +10 more
TL;DR: It needs intensive effort, expensive techniques and is demanding for the patients, but it offers tremendous opportunity for couples whose previous child has exhibited genetic abnormalities, and these applications are controversial.