Showing papers in "Cancer Genetics and Cytogenetics in 2008"

TL;DR: A high-resolution array comparative genomic hybridization study using an array of 4,046 bacterial artificial chromosome clones to screen for DNA copy number changes associated with individual genes in 36 tumors obtained from patients in early stages of NSCLC identified a series of genes in the critical 5p15.33 region that may be used as novel biomarkers for the early detection and classification of lung cancer.

TL;DR: The investigation revealed that miR-155 expression segregates with specific molecular subgroups of DLBCL and it is highest in activated B-cell (ABC)-type lymphomas and these tumors are characterized by constitutive activation of NF-kappaB signals, which supports the data derived from cell lines.

TL;DR: The identification of the GAS5 (growth arrest-specific transcript 5) gene as a novel partner of the BCL6 in a patient with diffuse large B-cell lymphoma, harboring the t(1;3)(q25;q27) gene is described.

TL;DR: The presence of the t(11;19)(q21;p13) rearrangement favors a diagnosis of MEC, and nested reverse transcriptase-polymerase chain reaction using RNA from 48 WTs confirmed the translocation in WT.

TL;DR: The hypothesis that the mtDNA G10398A polymorphism is, as has previously been reported, a marker of breast cancer risk in African Americans is not supported.

TL;DR: The low-producing variant C/C of IL6 may be a risk factor for bladder cancer, whereas high-producing genotypes of IL4 may predispose to higher risk in patients with high-grade or late-stage tumor and smoking habits.

TL;DR: The establishment, characterization, and tumorigenicity of a new epithelial cell line (UOK 257) derived from human renal carcinoma of an individual with Birt-Hogg-Dubé (BHD) syndrome are reported, which is the first established renal tumor cell line of BHD, an inheritable neoplastic syndrome.

TL;DR: In this paper, a review of available cytogenetic data and the karyotypes of 10 new cases of lipoblastoma, of which 7 could be studied further by fluorescence in situ hybridization (FISH) with regard to the involvement of the PLAG1 gene.

TL;DR: The occurrence of a BCR-JAK2 fusion gene in a case of acute myeloid leukemia (AML) resulting from a t(9;22)(p24;q11) translocation as the sole cytogenetic abnormality is reported.

TL;DR: The results indicate that VR1 has anti-HCC progression effects and can be potentially used as a prognostic indicator of HCC, and suggest the potential beneficiary effects of VR1 expression on the prognosis of patients with HCC.

TL;DR: Karyotypic rearrangements of 12q13 approximately q15 are considered recurrent in aggressive angiomyxoma, although reported in only five previous cases.

TL;DR: The results confirmed that the one-step mechanism is the most frequent, evidenced in 30 of 41 patients (73%); 3 patients demonstrated other more complex multistep events and 8 patients harbored ABL1 or BCR deletions that are not significantly associated with the complexity of translocation genesis.

TL;DR: FAS -1377 G-->A polymorphism may be associated with an increased risk of lymph node metastasis in Korean cervical cancer patients and polymorphisms of the death pathway genes FAS and FASL were explored.

TL;DR: It is hypothesized that the HH genotype increases the affinity of the FcgammaRIIa receptor, not only for naturally occurring IgG2, but also to ameliorate connection with chimeric IgG1 rituximab, contributing to a genetic individual profile of great interest in clinical onco-hematology.

TL;DR: In this paper, a case of hemosiderotic fibrolipomatous tumor arising within the subcutaneous tissue of the right foot, dorsal aspect, of an otherwise healthy 35-year-old woman was reported.

TL;DR: There was no evidence of methylation in the PTCH1-1B promoter in the MB cases examined, nor was there methylationIn the control cerebellum samples, and future directions include examination of distal regions of thePTCHlb promoter as well as alternative exon variants, most notably the CpG island containing PTCH 1-1C promoter.

TL;DR: Molecular cytogenetic investigation identified the cognate genomic breakpoints within chromosome 21 and 22, mandatory for the excision and exchange of both 3'ERG and 3'EWS, resulting in the formation of the EWS-ERG fusion gene present on the der(22).

TL;DR: The results suggest that ABCB1/MDR1 is a novel low-penetrance gene for susceptibility to MSI-H tumors, and the MDR1/ABCB1 genotype, allele, and haplotype frequencies are confirmed.

TL;DR: It is demonstrated that P PM1D is involved in the regulation of cell proliferation in breast cancer in a p53-dependent manner and that overexpression of PPM1D contributes to malignant phenotype by promoting sustained cell growth and cell survival.

TL;DR: Regions of LOH and copy number changes identified from this analysis may provide insights into the underlying processes of and genes involved in breast carcinogenesis, and a feasible methodological approach is demonstrated.

TL;DR: High-density single nucleotide polymorphism array analysis suggests that CREB3L4, INTS3, and SNAPAP are probable targets for the amplification mechanism and may therefore be involved, together or separately, in the development or progression of HCCs.

TL;DR: The role of mutant allele of ER and CYP17 in the development and progression of prostate cancer is indicated and any increased risk with PSA polymorphism in the north Indian population is ruled out.

TL;DR: It is shown that a low-grade ESS cell line carrying a der(7)t(6;7)(p21;p22) also harbors the a JAZF1/PHF1 fusion, and its oncogenic mechanism should be similar to that of the JAZf1/SUZ12 protein.

TL;DR: This study demonstrates that the detection of ETS fusion gene by RT-PCR is feasible on formalin-fixed and paraffin-embedded samples and confirms the hypothesis that recurrent specific aberrations such as fusion genes may be as frequent in epithelial tumors as they are in leukemias and sarcomas.

TL;DR: Pediatric anaplastic intracranial ependymomas harboring the 6q25.3 deletion showed significantly longer overall survival than did patients of the same group without the aberration, independent of the extent of resection, and supports the identified deletion on 6q 25.3 as a candidate favorable prognostic parameter and warrants further investigation.

TL;DR: In this paper, the authors performed fluorescence in situ hybridization and immunohistochemical analyses in five early gastric adenocarcinomas in individuals from northern Brazil.

TL;DR: Methylation in NSCLC tumors was not correlated with the clinicopathologic features of the patients, such as age, gender, and histology and pathologic staging of the tumor.

TL;DR: Cytogenetic analysis of two solitary fibrous tumors, one peritoneal and the other arising in the liver, revealed predominantly structural abnormalities in the former and numerical imbalances in the latter.

TL;DR: Analysis of clinicopathologic association revealed a convincing correlation with positive estrogen/progesterone receptor status and a twofold reduction in gene copy number in the MCF7 cell line strongly suggests the involvement of H2AFX alteration in breast carcinogenesis.

TL;DR: Cytogenetic and multicolor fluorescence in situ hybridization (FISH) analysis detected several chromosomal abnormalities that included an amplification of 9p that may play a crucial role in the pathogenesis or evolution of PV.