Z
Zena Werb
Researcher at University of California, San Francisco
Publications - 478
Citations - 134270
Zena Werb is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Extracellular matrix & Matrix metalloproteinase. The author has an hindex of 168, co-authored 473 publications receiving 122629 citations. Previous affiliations of Zena Werb include Rockefeller University & University of Southern California.
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Journal ArticleDOI
Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression
Christine D. Pozniak,Abraham J. Langseth,Gerrit J. P. Dijkgraaf,Youngshik Choe,Zena Werb,Samuel J. Pleasure +5 more
TL;DR: It is shown that the SoxE transcription factors (comprising Sox8, 9, and 10) induce multipotent neural precursor cells (NPCs) from the early postnatal subventricular zone (SVZ) to become OPCs in an autonomous manner and concludes that Sox10 acts to restrict the potential of NPCs toward the oligodendrocyte lineage in part by regulating the expression of Sufu.
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Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity.
Johanna I. Partanen,Topi A. Tervonen,Mikko Myllynen,Essi Lind,Misa Imai,Pekka Katajisto,Gerrit J. P. Dijkgraaf,Panu E. Kovanen,Tomi P. Mäkelä,Zena Werb,Juha Klefström +10 more
TL;DR: It is shown that conditional deletion of tumor suppressor gene Lkb1 (Par-4) in the mammary gland compromises epithelial integrity manifested by mislocalization of cell polarity markers, lateralization of tight junctions, deterioration of desmosomes and basement membrane (BM), and hyperbranching of the Mammary ductal tree.
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Matrix Metalloproteinases and Neurotrauma: Evolving Roles in Injury and Reparative Processes
TL;DR: The authors provide a brief overview of MMPs and their regulation, address their complex roles following traumatic injuries to the adult and developing CNS, and consider their time- and context-dependent signatures that influence both injury and reparative processes.
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MMP9 regulates the cellular response to inflammation after skeletal injury
Xiaodong Wang,Yan Yiu Yu,Shirley Lieu,Frank Yang,Jeffrey Lang,Chuanyong Lu,Zena Werb,Diane Hu,Theodore Miclau,Ralph S. Marcucio,Céline Colnot,Céline Colnot +11 more
TL;DR: Results show that MMP9 mediates indirect effects on skeletal cell differentiation by regulating the inflammatory response and the distribution of inflammatory cells, leading to the local regulation of periosteal cell differentiation.
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MMP9 and SCF Protect from Apoptosis in Acute Kidney Injury
Soraya Bengatta,Catherine Arnould,Emmanuel Letavernier,Matthieu Monge,Hélène Martinan de Préneuf,Zena Werb,Pierre Ronco,Brigitte Lelongt +7 more
TL;DR: Data show that MMP9 protects the S3 segment of the proximal tubule and the I-CD from apoptosis in AKI, most likely by releasing sSCF.