Z
Zena Werb
Researcher at University of California, San Francisco
Publications - 478
Citations - 134270
Zena Werb is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Extracellular matrix & Matrix metalloproteinase. The author has an hindex of 168, co-authored 473 publications receiving 122629 citations. Previous affiliations of Zena Werb include Rockefeller University & University of Southern California.
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Journal ArticleDOI
Deficiency in matrix metalloproteinase-2 results in long-term vascular instability and regression in the injured mouse spinal cord.
Alpa Trivedi,Haoqian Zhang,Adanma Ekeledo,Sang Mi Lee,Zena Werb,Giles W. Plant,Linda J. Noble-Haeusslein +6 more
TL;DR: Acting in the absence of MMP-2, M MP-9 transiently supports angiogenesis during the early phase of wound healing while its prolonged expression leads to vascular instability and regression, which should be considered while developing therapeutic interventions that block MMPs.
Journal ArticleDOI
Transcriptional regulation of stromelysin-1 gene expression is altered during progression of mouse mammary epithelial cells from functionally normal to malignant.
TL;DR: The switch in transcriptional regulation of stromelysin-1 expression that occurs during epithelial-to-mesenchymal transition and conversion to tumorigenicity is related to altered regulation of signals from the cytoarchitecture.
Book ChapterDOI
The cell and molecular biology of apolipoprotein E synthesis by macrophages.
Zena Werb,Jennie R. Chin,Relko Takemura,Rosa Laura Oropeza,Dorothy F. Bainton,Paula E. Stenberg,John M. Taylor,Catherine A. Reardon +7 more
TL;DR: ApoE mRNA first appears as monocytes differentiate into macrophages, and this expression is paralleled by the secretion of ApoE by the cells as discussed by the authors, suggesting that this decrease occurs largely at the translational level.
Journal ArticleDOI
Immunochemical studies with a specific antiserum to rabbit fibroblast collagenase.
Zena Werb,John J. Reynolds +1 more
TL;DR: Antisera were raised against the collagenase from rabbit synovial fibroblasts and characterized by immunoprecipitation and immunoinhibition reactions and were potent inhibitors of the action of rabbit collagenase on both reconstituted collagen fibrils and collagen in solution.
Journal ArticleDOI
The role of metalloproteinases and their inhibitors in regulating mammary epithelial morphology and function in vivo
Carolyn J. Sympson,Carolyn J. Sympson,Rabih S. Talhouk,Rabih S. Talhouk,Mina J. Bissell,Zena Werb +5 more
TL;DR: It is suggested that overexpression of SL-1 and disruption of the BM may play a key role in mammary gland branching morphogenesis, apoptosis and breast cancer induction and progression.