Z
Zena Werb
Researcher at University of California, San Francisco
Publications - 478
Citations - 134270
Zena Werb is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Extracellular matrix & Matrix metalloproteinase. The author has an hindex of 168, co-authored 473 publications receiving 122629 citations. Previous affiliations of Zena Werb include Rockefeller University & University of Southern California.
Papers
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Journal ArticleDOI
Stromal regulation of vessel stability by MMP14 and TGFbeta.
Nor E. Sounni,Kerstin Dehne,Léon C van Kempen,Mikala Egeblad,Nesrine I. Affara,Ileana Cuevas,Jane F. Wiesen,Simon Junankar,Lidiya Korets,Jake Lee,Jennifer Shen,Charlotte J. Morrison,Christopher M. Overall,Stephen M. Krane,Zena Werb,Nancy Boudreau,Lisa M. Coussens +16 more
TL;DR: A central pathway involving MMP14 and TGFβ that mediates vessel stability and vascular response to tissue injury is defined and antagonists of this pathway could be therapeutically exploited to improve the delivery of therapeutics or molecular contrast agents into tissues where chronic damage or neoplastic disease limits their efficient delivery.
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Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-1 in the Retinal Pigment Epithelium and Interphotoreceptor Matrix: Vectorial Secretion and Regulation
TL;DR: Analysis of expression of MMP-2 and TIMP-1 in the retinal pigment epithelium of rats with inherited retinal dystrophy suggests that the integrity of Bruch's membrane may serve to regulate RPE functions in MMP and TimP secretion and that extracellular matrices contain signals that regulate MMPand TIMP synthesis and/or secretion by the RPE.
Journal ArticleDOI
Monitoring of Vital Signs for Long-Term Survival of Mice under Anesthesia
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Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization
TL;DR: Results indicate that Zeppo1 is a key regulator of breast cancer progression and overexpression in a mouse breast cancer model increases lung metastases, while reducingZeppo1 expression reduces both tumor size and the number of Lung metastases.