Z
Zeynep Dogusan
Researcher at Université libre de Bruxelles
Publications - 8
Citations - 1148
Zeynep Dogusan is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: Endoplasmic reticulum & Apoptosis. The author has an hindex of 6, co-authored 6 publications receiving 1102 citations.
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Journal ArticleDOI
Free Fatty Acids and Cytokines Induce Pancreatic β-Cell Apoptosis by Different Mechanisms: Role of Nuclear Factor-κB and Endoplasmic Reticulum Stress
Ilham Kharroubi,Laurence Ladrière,Alessandra K Cardozo,Zeynep Dogusan,Miriam Cnop,Decio L. Eizirik +5 more
TL;DR: It is concluded that apoptosis is the main mode of FFA- and cytokine-induced beta-cell death but the mechanisms involved are different, suggesting that FFAs trigger an endoplasmic reticulum (ER) stress response through an NF-kappaB- and nitric oxide-independent mechanism.
Journal ArticleDOI
Selective Inhibition of Eukaryotic Translation Initiation Factor 2α Dephosphorylation Potentiates Fatty Acid-induced Endoplasmic Reticulum Stress and Causes Pancreatic β-Cell Dysfunction and Apoptosis
Miriam Cnop,Miriam Cnop,Laurence Ladrière,Paul Hekerman,Fernanda Ortis,Alessandra K Cardozo,Zeynep Dogusan,Daisy Flamez,Michael Boyce,Junying Yuan,Decio L. Eizirik +10 more
TL;DR: It is demonstrated that excessive eIF2α phosphorylation is poorly tolerated by β-cells and exacerbates free fatty acid-induced apoptosis, which modifies the present paradigm regarding the beneficial role of eIF 2 α phosphorylated cells and must be taken into consideration when designing therapies to protect β- cells in type 2 diabetes.
Journal ArticleDOI
Toll-like Receptor 3 and STAT-1 Contribute to Double-stranded RNA+ Interferon-γ-induced Apoptosis in Primary Pancreatic β-Cells
Joanne Rasschaert,Laurence Ladrière,Maryse Urbain,Zeynep Dogusan,Bitshilualua Katabua,Shintaro Sato,Shizuo Akira,Conny Gysemans,Chantal Mathieu,Decio L. Eizirik +9 more
TL;DR: It is suggested that dsRNA plus IFN-γ triggers β-cell apoptosis by two complementary pathways, namely TLR3-TRIF-NF-κB and STAT-1.
Journal ArticleDOI
Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways.
Zeynep Dogusan,Mónica García,Daisy Flamez,Lena Alexopoulou,Michel Goldman,Conny Gysemans,Chantal Mathieu,Claude Libert,Decio L. Eizirik,Joanne Rasschaert +9 more
TL;DR: PICex and PICin trigger β-cell apoptosis via the TLR3 pathway or IRF-3 signaling, respectively, and execution of Picin-mediated apoptosis depends on autocrine effects of type I IFNs.
Selective Inhibition of Eukaryotic Translation Initiation Factor 2 Dephosphorylation Potentiates Fatty Acid-induced Endoplasmic Reticulum Stress and Causes Pancreatic
Miriam Cnop,Laurence Ladrière,Paul Hekerman,Fernanda Ortis,Alessandra K. Cardozo,Zeynep Dogusan,Daisy Flamez,Michael Boyce,Junying Yuan,Decio L. Eizirik +9 more
TL;DR: In this paper, Salubrinal selectively inhibitseIF2 dephosphorylation, protecting other cells against endo-plasmic reticulum stress-mediated apoptosis, and has beenproposed as a -cell protector.