Z
Zhan Zhang
Researcher at Georgia State University
Publications - 15
Citations - 1627
Zhan Zhang is an academic researcher from Georgia State University. The author has contributed to research in topics: Colitis & Drug delivery. The author has an hindex of 11, co-authored 15 publications receiving 1004 citations. Previous affiliations of Zhan Zhang include Yerkes National Primate Research Center.
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Journal ArticleDOI
Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer.
Mingzhen Zhang,Emilie Viennois,Meena A. Prasad,Yunchen Zhang,Lixin Wang,Zhan Zhang,Moon Kwon Han,Bo Xiao,Changlong Xu,Shanthi Srinivasan,Didier Merlin +10 more
TL;DR: GDNPs 2, nanoparticles derived from edible ginger, represent a novel, natural delivery mechanism for improving IBD prevention and treatment with an added benefit of overcoming limitations such as potential toxicity and limited production scale that are common with synthetic nanoparticles.
Journal ArticleDOI
Prevention and cure of rotavirus infection via TLR5/NLRC4–mediated production of IL-22 and IL-18
Benyue Zhang,Benoit Chassaing,Zhenda Shi,Robin Uchiyama,Zhan Zhang,Timothy L. Denning,Timothy L. Denning,Sue E. Crawford,Andrea J. Pruijssers,Jason A. Iskarpatyoti,Mary K. Estes,Terence S. Dermody,Wenjun Ouyang,Ifor R. Williams,Matam Vijay-Kumar,Andrew T. Gewirtz,Andrew T. Gewirtz +16 more
TL;DR: Treatment with bacterial flagellin prevented rotavirus (RV) infection in mice and cured chronically RV-infected mice and holds promise as a broad-spectrum antiviral agent.
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Edible Ginger-derived Nano-lipids Loaded with Doxorubicin as a Novel Drug-delivery Approach for Colon Cancer Therapy.
Mingzhen Zhang,Bo Xiao,Bo Xiao,Huan Wang,Moon Kwon Han,Zhan Zhang,Emilie Viennois,Changlong Xu,Changlong Xu,Didier Merlin,Didier Merlin +10 more
TL;DR: A nanovector made from ginger-derived lipids that can serve as a delivery platform for the therapeutic agent doxorubicin (Dox) to treat colon cancer and was capable of loading Dox with high efficiency and showed a better pH-dependent drug-release profile than commercially available liposomal-Dox.
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Nanoparticles with surface antibody against CD98 and carrying CD98 small interfering RNA reduce colitis in mice
Bo Xiao,Hamed Laroui,Emilie Viennois,Emilie Viennois,Saravanan Ayyadurai,Moiz A. Charania,Yuchen Zhang,Zhan Zhang,Mark T. Baker,Benyue Zhang,Andrew T. Gewirtz,Andrew T. Gewirtz,Didier Merlin,Didier Merlin +13 more
TL;DR: Nanoparticles containing surface CD98 antibody and loaded with siCD98 reduce expression of this protein by colonic epithelial cells and macrophages, and oral administration decreases the severity of colitis in mice.
Journal ArticleDOI
Combination Therapy for Ulcerative Colitis: Orally Targeted Nanoparticles Prevent Mucosal Damage and Relieve Inflammation.
Bo Xiao,Zhan Zhang,Emilie Viennois,Yuejun Kang,Mingzhen Zhang,Moon Kwon Han,Jiucun Chen,Didier Merlin +7 more
TL;DR: This study shows the promising capability of the co-delivered siCD98 and CUR for boosting the conventional monotherapy via this novel nanotherapeutic agent, which offers a structurally simple platform for orally administered delivery of drugs to target cells in UC therapy.