Combination Therapy for Ulcerative Colitis: Orally Targeted Nanoparticles Prevent Mucosal Damage and Relieve Inflammation.
Bo Xiao,Zhan Zhang,Emilie Viennois,Yuejun Kang,Mingzhen Zhang,Moon Kwon Han,Jiucun Chen,Didier Merlin +7 more
TLDR
This study shows the promising capability of the co-delivered siCD98 and CUR for boosting the conventional monotherapy via this novel nanotherapeutic agent, which offers a structurally simple platform for orally administered delivery of drugs to target cells in UC therapy.Abstract:
Combination therapy is an emerging strategy that is under intensive preclinical investigation for the treatment of various diseases. CD98 is highly overexpressed on the surfaces of epithelial cells and macrophages in the colon tissue with ulcerative colitis (UC), which is usually associated with mucosal damage and inflammation. We previously proved that CD98 siRNA (siCD98)-induced down-regulation of CD98 in colitis tissue decreased the severity of UC to a certain extent. In an effort to further improve the therapeutic efficacy, we aim to simultaneously deliver siCD98 in combination with a potent anti-inflammatory agent, curcumin (CUR), using hyaluronic acid (HA)-functionalized polymeric nanoparticles (NPs). The resultant spherical HA-siCD98/CUR-NPs are featured by a desirable particle size (∼246 nm) and slightly negative zeta potential (∼-14 mV). The NPs functionalized with HA are able to guide the co-delivery of drugs to the targeted cells related to UC therapy (colonic epithelial cells and macrophages). Compared to either siCD98- or CUR-based monotherapy, co-delivery of siCD98 and CUR by HA-functionalized NPs can exert combinational effects against UC by protecting the mucosal layer and alleviating inflammation both in vitro and in vivo. This study shows the promising capability of the co-delivered siCD98 and CUR for boosting the conventional monotherapy via this novel nanotherapeutic agent, which offers a structurally simple platform for orally administered delivery of drugs to target cells in UC therapy.read more
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Identifying and Characterizing circRNA-Protein Interaction.
William W. Du,Chao Zhang,Chao Zhang,Weining Yang,Tianqiao Yong,Faryal Mehwish Awan,Faryal Mehwish Awan,Faryal Mehwish Awan,Burton B. Yang,Burton B. Yang +9 more
TL;DR: It is hypothesized that circRNAs may bind, store, sort, and sequester proteins to particular subcellular locations, and act as dynamic scaffolding molecules that modulate protein-protein interactions.
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Hyaluronic acid–bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis
TL;DR: HABN associated with pro-inflammatory macrophages, regulated innate immune responses and exerted potent therapeutic efficacy against colitis, and modulates the gut microbiota, increasing the overall richness and diversity and markedly augmenting the abundance of Akkermansia muciniphila and Clostridium XIVα.
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Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects
Belén Begines,Tamara Ortiz,María Pérez-Aranda,Guillermo Martínez,Manuel Merinero,Federico Argüelles-Arias,Ana Alcudia +6 more
TL;DR: A summary of the state-of-the-art panorama of polymeric nanoparticles as drug-delivery systems has been conducted, focusing mainly on those applications in which the corresponding disease involves an important morbidity, a considerable reduction in the life quality of patients—or even a high mortality.
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Drug delivery systems for RNA therapeutics
TL;DR: A review of RNA therapeutic classes, their molecular mechanisms of action, and the design considerations for their respective delivery platforms can be found in this paper , where the authors discuss the path from preclinical drug delivery research to clinical approval of these drugs.
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Polymeric Nanoparticles in Gene Therapy: New Avenues of Design and Optimization for Delivery Applications.
TL;DR: The introduction of polymers in medicine is outlined, the methods of polymer synthesis, addressing top down and bottom up techniques are discussed, and the applications of the polymeric delivery systems in gene therapy are explored.
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