Z
Zhen Zhang
Researcher at Johns Hopkins University
Publications - 224
Citations - 16297
Zhen Zhang is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 57, co-authored 189 publications receiving 13444 citations. Previous affiliations of Zhen Zhang include Medical University of South Carolina & Children's National Medical Center.
Papers
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Journal ArticleDOI
Differential dependency network analysis to identify condition-specific topological changes in biological networks
Bai Zhang,Huai Li,Rebecca B. Riggins,Ming Zhan,Jianhua Xuan,Zhen Zhang,Eric P. Hoffman,Robert Clarke,Yue Wang +8 more
TL;DR: A differential dependency network (DDN) analysis to detect statistically significant topological changes in the transcriptional networks between two biological conditions is reported and is expected to emerge as an important bioinformatics tool in transcriptional network analyses.
Journal ArticleDOI
Glycoproteomics for prostate cancer detection: changes in serum PSA glycosylation patterns
TL;DR: Five lectin immunosorbant assays to analyze the glycosylation patterns of PSA in serum suggest these assays may have a potential role in improving PSA's cancer specificity.
Journal ArticleDOI
Analytical Validation of Serum Proteomic Profiling for Diagnosis of Prostate Cancer: Sources of Sample Bias
Dale McLerran,William E. Grizzle,Ziding Feng,William L. Bigbee,Lionel L. Bañez,Lisa H. Cazares,Daniel W. Chan,Jose I. Diaz,Elzbieta Izbicka,Jacob Kagan,David E. Malehorn,Gunjan Malik,Denise K. Oelschlager,Alan W. Partin,Timothy W. Randolph,Nicole Rosenzweig,Shiv Srivastava,Sudhir Srivastava,Ian M. Thompson,Mark D. Thornquist,Dean A. Troyer,Yutaka Yasui,Zhen Zhang,Liu Zhu,O. John Semmes +24 more
TL;DR: The ability of the decision algorithm to successfully differentiate between prostate cancer, BPH, and control samples using data derived from serum protein profiling was compromised by bias.
Journal Article
Identifying tumor origin using a gene expression-based classification map.
Phillip Buckhaults,Zhen Zhang,Yu Chi Chen,Tian Li Wang,Brad St. Croix,Saurabh Saha,Alberto Bardelli,Patrice J. Morin,Kornelia Polyak,Ralph H. Hruban,Victor E. Velculescu,Ie Ming Shih +11 more
TL;DR: A classification map diagnostic of tumor types was generated based on expression patterns of five genes selected from the SAGE database, providing a reliable and practical approach to determine tumor type in cases of metastatic carcinoma of clinically unknown origin.
Journal ArticleDOI
Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules.
Yu Yu,Stephanie Gaillard,Jude M. Phillip,Tai-Chung Huang,Sneha M. Pinto,Nayara G. Tessarollo,Nayara G. Tessarollo,Zhen Zhang,Akhilesh Pandey,Denis Wirtz,Ayse Ayhan,Ayse Ayhan,Ben Davidson,Ben Davidson,Tian Li Wang,Ie Ming Shih +15 more
TL;DR: It is reported that recurrent ovarian carcinomas after paclitaxel/carboplatin treatment have higher levels of spleen tyrosine kinase (SYK) and phospho-SYK, and targeting SYK pathway is a promising strategy to enhance pac litaxel response.