Z
Zhen Zhang
Researcher at Johns Hopkins University
Publications - 224
Citations - 16297
Zhen Zhang is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 57, co-authored 189 publications receiving 13444 citations. Previous affiliations of Zhen Zhang include Medical University of South Carolina & Children's National Medical Center.
Papers
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Journal ArticleDOI
Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
Patrick G. Shaw,Patrick G. Shaw,Raghothama Chaerkady,Zhen Zhang,Nancy E. Davidson,Nancy E. Davidson,Akhilesh Pandey +6 more
TL;DR: This study demonstrates that immunoaffinity enrichment of acetylated peptides is somewhat limited by substrate specificity and that an optimal yield of enrichment can be achieved by employing a broader array of affinity reagents.
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Predicting Ovarian Cancer Patients’ Clinical Response to Platinum-Based Chemotherapy by Their Tumor Proteomic Signatures
TL;DR: It is demonstrated that proteomic profiles of ovarian serous carcinoma patients predicted platinum drug responses as well as provided insights into the biological processes influencing the efficacy of platinum-based therapeutics.
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Validation of a Biomarker Panel and Longitudinal Biomarker Performance for Early Detection of Ovarian Cancer.
Archana R. Simmons,Charlotte H. Clarke,Donna Badgwell,Zhen Lu,Lori J. Sokoll,Karen H. Lu,Zhen Zhang,Robert C. Bast,Steven J. Skates +8 more
TL;DR: The multiplex panel chosen is suitable for the early detection of ovarian cancer and the individual markers have their own baseline permitting longitudinal algorithm development.
Journal ArticleDOI
Proteomic approaches to tumor marker discovery: Identification of biomarkers for ovarian cancer
Alex J. Rai,Zhen Zhang,Jason M. Rosenzweig,Le ming Shih,Thang Pham,Eric T. Fung,Lori J. Sokoll,Daniel W. Chan +7 more
TL;DR: In this paper, the authors compared results between patients with and without cancer and evaluated their discriminatory performance against that of the cancer antigen 125 (CA125) tumor marker using proteomic profiling and bioinformatics.
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Overexpression of periostin in stroma positively associated with aggressive prostate cancer.
Yuan Tian,Caitlin H. Choi,Qing Kay Li,Farah Rahmatpanah,Xin Chen,Sara Ruth Kim,Robert W. Veltri,David Chia,Zhen Zhang,Dan Mercola,Hui Zhang +10 more
TL;DR: Periostin staining was positively correlated with increasing Gleason score and the aggressiveness of prostate disease and was observed mainly in peritumoral stromal cells and in some cases in tumor epithelial cells.