Z
Zheng Chen
Researcher at University of Miami
Publications - 15
Citations - 1026
Zheng Chen is an academic researcher from University of Miami. The author has contributed to research in topics: Cancer & Carcinogenesis. The author has an hindex of 11, co-authored 15 publications receiving 592 citations. Previous affiliations of Zheng Chen include Nanjing Medical University & United States Department of Veterans Affairs.
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Journal ArticleDOI
Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway
Xing Zhang,Sen Wang,Haixiao Wang,Jiacheng Cao,Xiaoxu Huang,Zheng Chen,Penghui Xu,Guangli Sun,Jianghao Xu,Jialun Lv,Zekuan Xu +10 more
TL;DR: It is proved that circNRIP1 sponges miR-149-5p to affect the expression level of AKT1 and eventually acts as a tumour promotor in GC and demonstrated that quaking can promote circ NRIP1 transcription.
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Novel role of miR-133a-3p in repressing gastric cancer growth and metastasis via blocking autophagy-mediated glutaminolysis
Xing Zhang,Zheng Li,Zhe Xuan,Penghui Xu,Weizhi Wang,Zheng Chen,Sen Wang,Guangli Sun,Jianghao Xu,Zekuan Xu +9 more
TL;DR: It is demonstrated that microRNA-133a-3p overexpression could block the activation of autophagy to ruin the abnormal glutaminolysis and further inhibit the growth and metastasis of gastric cancer cells.
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Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers.
Ahmed Gomaa,Dunfa Peng,Zheng Chen,Zheng Chen,Mohammed Soutto,Mohammed Soutto,Khaled Abouelezz,Alejandro H. Corvalan,Wael El-Rifai,Wael El-Rifai +9 more
TL;DR: A novel epigenetic mechanism mediating silencing of miR-4715-3p and induction of AURKA in UGCs is identified and putative binding sites on the 3UTR region of Aurora kinase A are found.
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PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer
Sen Wang,Zheng Chen,Shoumin Zhu,Heng Lu,Dunfa Peng,Mohammed Soutto,Huma Naz,Richard M. Peek,Hao Xu,Alexander Zaika,Zekuan Xu,Wael El-Rifai,Wael El-Rifai +12 more
TL;DR: The data suggest that the future development of therapeutic approaches targeting PRDX2 may be useful in the treatment of gastric cancer.
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Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1
Lihong Wang-Bishop,Zheng Chen,Ahmed Gomaa,Albert C. Lockhart,Safia N. Salaria,Jialiang Wang,Keeli B. Lewis,Jeffrey Ecsedy,Kay Washington,R.D. Beauchamp,Wael El-Rifai,Wael El-Rifai +11 more
TL;DR: In studies of gastrointestinal cancer cell lines with activated KRAS, AURKA is found to phosphorylate RPS6KB1, promoting cell proliferation and survival and growth of xenograft tumors in mice.