Z
Zhifeng Xiao
Researcher at Chinese Academy of Sciences
Publications - 168
Citations - 6498
Zhifeng Xiao is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Spinal cord injury & Neural stem cell. The author has an hindex of 46, co-authored 168 publications receiving 5050 citations. Previous affiliations of Zhifeng Xiao include Third Military Medical University.
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The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs.
TL;DR: High-level expression of CSC-associated properties of MCF-7 cells cultured in 3D was further confirmed by high tumorigenicity in vivo, and 3D collagen scaffolds might provide a useful platform for anti-cancer therapeutics and CSC research.
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Transplantation of human mesenchymal stem cells loaded on collagen scaffolds for the treatment of traumatic brain injury in rats.
Jian-Guo Guan,Zhaohui Zhu,Robert Chunhua Zhao,Zhifeng Xiao,Chenxi Wu,Qin Han,Lei Chen,Wei-Min Tong,Jin Zhang,Qianqian Han,Jun Gao,Ming Feng,Xinjie Bao,Jianwu Dai,Renzhi Wang +14 more
TL;DR: It is speculated that collagen scaffolds would improve early engraftment and support the survival of grafted cells post-transplantation and brain metabolism also improved in the collagen scaffold implanted group, as evaluated by PET.
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Linear Ordered Collagen Scaffolds Loaded with Collagen-Binding Brain-Derived Neurotrophic Factor Improve the Recovery of Spinal Cord Injury in Rats
Qianqian Han,Wenjie Sun,Hang Lin,Wenxue Zhao,Yuan Gao,Yannan Zhao,Bing Chen,Zhifeng Xiao,Wei Hu,Yuan Li,Bo Yang,Jianwu Dai +11 more
TL;DR: Using the rat hemisection SCI model, it is found that LOCS loaded with CBD-BDNF significantly improved the SCI recovery evaluated by the Basso, Beattie, and Bresnahan scale and immunohistochemical staining with anti-neurofilament antibody.
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The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an EGFR neutralizing antibody
Qianqian Han,Wei Jin,Zhifeng Xiao,Hongbin Ni,Jinhuan Wang,Jie Kong,Jun Wu,Weibang Liang,Lei Chen,Yannan Zhao,Bing Chen,Jianwu Dai +11 more
TL;DR: Results showed that this collagen scaffold with the addition of 151IgG and CBD-BDNF provided effective bridging and stimulation effects for neural regeneration, recovery of electrical transmission of synapses and preventing the formation of glial scars in the extreme transected rat SCI model.
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The effect of collagen-binding NGF-β on the promotion of sciatic nerve regeneration in a rat sciatic nerve crush injury model
Wenjie Sun,Changkai Sun,Hang Lin,Hui Zhao,Jingyu Wang,Hui Ma,Bing Chen,Zhifeng Xiao,Jianwu Dai +8 more
TL;DR: In the rat sciatic nerve crush injury model, it is found that collagen-binding NGF could be retained and concentrated at the nerve injured site to promote nerve repair and enhance function recovery following nerve damage.