Z
Zhilin Liu
Researcher at Baylor College of Medicine
Publications - 39
Citations - 2700
Zhilin Liu is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Granulosa cell & Ovulation. The author has an hindex of 24, co-authored 36 publications receiving 2357 citations. Previous affiliations of Zhilin Liu include University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
MAPK3/1 (ERK1/2) in Ovarian Granulosa Cells Are Essential for Female Fertility
Heng-Yu Fan,Zhilin Liu,Masayuki Shimada,Esta Sterneck,Peter F. Johnson,Stephen M. Hedrick,JoAnne S. Richards +6 more
TL;DR: Targeted disruption of the kinases ERK1 and ERK2 in mouse granulosa cells provides in vivo evidence that these kinases are necessary for LH-induced oocyte resumption of meiosis, ovulation, and luteinization-related events.
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Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cells.
TL;DR: The novel evidence that Pten impacts the survival/life span of granulosa/luteal cells and that its loss not only results in the facilitated ovulation but also in the persistence of nonsteroidogenic luteal structures in the adult mouse ovary is provided.
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Selective expression of KrasG12D in granulosa cells of the mouse ovary causes defects in follicle development and ovulation
Heng-Yu Fan,Masayuki Shimada,Zhilin Liu,Nicola Cahill,Noritaka Noma,Yun Wu,Jan A. Gossen,Jo Anne S. Richards +7 more
TL;DR: Transient but not sustained activation of RAS in granulosa cells is crucial for directing normal follicle development and initiating the ovulation process, leading to the persistence of abnormal non-mitotic, non-apoptotic cells rather than tumorigenic cells.
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β-Catenin (CTNNB1) Promotes Preovulatory Follicular Development but Represses LH-Mediated Ovulation and Luteinization
Heng-Yu Fan,Annalouise O'Connor,Manami Shitanaka,Masayuki Shimada,Zhilin Liu,JoAnne S. Richards +5 more
TL;DR: Wingless-type mouse mammary tumor virus integration site family (WNT)/beta-catenin pathway components are expressed in ovarian granulosa cells, direct female gonad development, and are regulated by the pituitary gonadotropins, but the in vivo functions of CTNNB1 remain unclear.
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Functional roles of the phosphatidylinositol 3-kinases (PI3Ks) signaling in the mammalian ovary
TL;DR: This review summarizes the physiological function of intra-oocyte PI3K signaling in regulation of primordial follicle survival and activation, and the pathological function of PI3k signaling in ovarian diseases such as premature ovarian failure, granulosa cell tumors, and ovarian surface epithelium carcinomas.