G
Guy Lahat
Researcher at Tel Aviv Sourasky Medical Center
Publications - 124
Citations - 4179
Guy Lahat is an academic researcher from Tel Aviv Sourasky Medical Center. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 35, co-authored 99 publications receiving 3405 citations. Previous affiliations of Guy Lahat include University of Texas MD Anderson Cancer Center & University of Texas Health Science Center at Houston.
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Journal ArticleDOI
Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome.
Changye Zou,Kerrington D. Smith,Jun Liu,Guy Lahat,Sarah E. Myers,Wei Lien Wang,Wei Zhang,Ian E. McCutcheon,John M. Slopis,Alexander J. Lazar,Raphael E. Pollock,Dina Lev +11 more
TL;DR: MPSNT is a markedly metastatic and aggressive poor prognosis tumor and multiple clinical, pathologic, and molecular markers identified in this study, coupled with findings from previous series, should be considered for an improved MPNST staging system useful for prognostic assessment and management decisions.
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Management of Recurrent Retroperitoneal Sarcoma (RPS) in the Adult: A Consensus Approach from the Trans-Atlantic RPS Working Group
J. Ahlen,Nita Ahuja,R. Antbacka,Sanjay P. Bagaria,J.-Y. Blay,S. Bonvalot,Dario Callegaro,Robert J. Canter,Kenneth Cardona,Paolo G. Casali,Chiara Colombo,A. P. Dei Tos,A. De Paoli,Anant Desai,Brendan C. Dickson,Fritz C. Eilber,M. Fiore,Christopher D.M. Fletcher,Samuel J Ford,Hans Gelderblom,Ricardo J. Gonzalez,Giovanni Grignani,Grignol,Alessandro Gronchi,R. L. Haas,Andrew J. Hayes,Wolfgang Hartmann,T. Henzler,Peter Hohenberger,Antoine Italiano,Jens Jakob,Robin L. Jones,Ian Judson,John M. Kane,Guy Lahat,Andrea MacNeill,Roberta Maestro,Christina Messiou,Pierre Meeus,Rosalba Miceli,John T. Mullen,Carolyn Nessim,Elisabetta Pennacchioli,Venu G. Pillarisetty,Raphael E. Pollock,Quagliuolo,Stefano Radaelli,Chandrajit P. Raut,Piotr Rutkowski,Sergio Sandrucci,Yvonne Schrage,Jason K. Sicklick,Myles Smith,Silvia Stacchiotti,Eberhard Stoeckle,Dirk C. Strauss +55 more
TL;DR: In this paper, a transatlantic working group was established to share institutional experiences, build large multi-institutional case series, and develop consensus documents on the approach to recurrent soft tissue sarcomas.
Journal ArticleDOI
Vimentin is a novel AKT1 target mediating motility and invasion
Quansheng Zhu,Kevin P. Rosenblatt,Kai Lieh Huang,Guy Lahat,Reynolds Brobey,Svetlana Bolshakov,Theresa Nguyen,Zhiyong Ding,Roman Belousov,Kate Lynn J. Bill,Xuemei Luo,Alexander J. Lazar,Adam P. Dicker,Gordon B. Mills,Mien Chie Hung,Mien Chie Hung,Dina Lev +16 more
TL;DR: It is demonstrated that AKT1 activation induces STS cell motility and invasiveness at least partially through a novel interaction with the intermediate filament vimentin (Vim), which was shown to enhance tumor and metastasis growth in vivo.
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Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies.
Guy Lahat,Quansheng Zhu,Kai Lieh Huang,Suizhao Wang,Svetlana Bolshakov,Jeffery Liu,Keila E. Torres,Robert R. Langley,Alexander J. Lazar,Mien Chie Hung,Dina Lev +10 more
TL;DR: Evaluating Withaferin-A's effects on tumor growth in vitro and in vivo elucidating the role of vimentin in drug-induced responses in soft tissue sarcoma and “epithelial to mesenchymal transition” clinical contexts is warranted.
Journal ArticleDOI
Angiosarcoma: clinical and molecular insights.
Guy Lahat,Asha R. Dhuka,Hen Hallevi,Lianchun Xiao,Changye Zou,Kerrington D. Smith,Thuy L. Phung,Raphael E. Pollock,Robert S. Benjamin,Kelly K. Hunt,Alexander J. Lazar,Dina Lev +11 more
TL;DR: Data presented here support further study of the AKT/mTOR pathway as novel molecular targets for AS therapy and further unravel commonly deregulated molecular events of potential therapeutic utility.