Y
Yihan Wang
Researcher at Boston Medical Center
Publications - 23
Citations - 1073
Yihan Wang is an academic researcher from Boston Medical Center. The author has contributed to research in topics: Heat shock protein & Apoptosis. The author has an hindex of 16, co-authored 21 publications receiving 952 citations. Previous affiliations of Yihan Wang include Tufts Medical Center & Vanderbilt University.
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Journal ArticleDOI
Atg5-mediated autophagy deficiency in proximal tubules promotes cell cycle G2/M arrest and renal fibrosis.
Huiyan Li,Xuan Peng,Yating Wang,Shirong Cao,Liping Xiong,Jinjin Fan,Yihan Wang,Shougang Zhuang,Xueqing Yu,Haiping Mao +9 more
TL;DR: Atg5-mediated autophagy in proximal epithelial cells is a critical host-defense mechanism that prevents renal fibrosis by blocking G2/M arrest, suggesting the regulation of cell cycle progression by ATG5 is Autophagy dependent.
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Distinct hsp70 domains mediate apoptosis-inducing factor release and nuclear accumulation.
Kathleen L. Ruchalski,Haiping Mao,Zhijian Li,Zhiyong Wang,Sara Gillers,Yihan Wang,Dick D. Mosser,Vladimir L. Gabai,John H. Schwartz,Steen C Borkan +9 more
TL;DR: It is demonstrated that mitochondrial protection against bax-mediated injury requires both intact chaperone and ATPase functions, whereas the ATPase domain is critical for sequestering leaked AIF in the cytosol.
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HSP72 attenuates renal tubular cell apoptosis and interstitial fibrosis in obstructive nephropathy
Haiping Mao,Zhilian Li,Yi Zhou,Zhijian Li,Shougang Zhuang,Xin An,Baiyu Zhang,Wei Chen,Jing Nie,Zhiyong Wang,Steven C. Borkan,Yihan Wang,Xueqing Yu +12 more
TL;DR: The data indicate that HSP72 ameliorates renal tubulointerstitial fibrosis in obstructive nephropathy by inhibiting both renal tubular epithelial cell apoptosis and EMT.
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HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells.
Kathleen L. Ruchalski,Haiping Mao,Satish K. Singh,Yihan Wang,Dick D. Mosser,Fanghong Li,John H. Schwartz,Steven C. Borkan +7 more
TL;DR: It is suggested that mitochondrial membrane injury and subsequent AIF release contribute to nuclear injury and apoptosis in ATP-depleted renal cells and selective overexpression of human HSP72 reduced the leakage of mitochondrial AIF in a dose-dependent manner.
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Electrodiffusional ATP movement through the cystic fibrosis transmembrane conductance regulator
Horacio F. Cantiello,George R. Jackson,Claudio Grosman,A. G. Prat,Steven C. Borkan,Yihan Wang,I. L. Reisin,Catherine R. O'Riordan,Dennis A. Ausiello +8 more
TL;DR: It is reported that reconstitution into a lipid bilayer of highly purified CFTR of human epithelial origin enables the permeation of both Cl- and ATP.