Zhiyong Zhang

TL;DR: A novel method that uses the collective modes obtained with a coarse-grained model/anisotropic network model to guide the atomic-level simulations and may be further applied to important biological problems, such as long timescale functional motions, protein folding/unfolding, and structure prediction.

TL;DR: Structures-guided mutagenesis analyses and molecular dynamic simulation enabled us to elucidate that SraP binding to sialylated receptors promotes S. aureus adhesion to and invasion into host epithelial cells, providing novel structural and functional insights into the SRAP-mediated host-pathogen interaction of S.Aureus.

TL;DR: Aurora-A modulates the activity of lactate dehydrogenase B, resulting in enhanced glycolysis, bio-synthesis and tumour growth, and a mechanism through which LDHB directly contributes to the Warburg effect is uncovered.

TL;DR: A unique binding pattern of the PWWP domain of Pdp1 bound not only to H4K20me3 (trimethylated Lys(20) of histone H4), but also to dsDNA (double-stranded DNA) via an aromatic cage and a positively charged area respectively.

TL;DR: Structural analyses combined with computational simulations and biochemical assays suggest a pore‐forming process with an activation mechanism distinct from the previously characterized bacterial members, and Dln1 and its homologs are ubiquitously distributed in bony fishes and lamprey, suggesting a novel fish‐specific defense molecule.