Zoe Cariad Prytherch

TL;DR: There is an urgent need for engineered tissue equivalents of the lung given the increase in pharmaceutically valuable drugs, toxicity testing of environmental pollutants and the advent of nanotoxicology.

TL;DR: Exhaust fumes from a ship engine running on either common heavy fuel oil (HFO) or cleaner-burning diesel fuel (DF) influenced several essential pathways of lung cell metabolism more strongly than particles from the unrefined fuel HFO, which might be attributable to a higher soot content in DF.

TL;DR: In this article, an air-liquid interface exposure system was used to evaluate human lung cells under realistic in vitro conditions to exhaust fumes from a ship engine running on either common heavy fuel oil (HFO) or cleaner-burning diesel fuel (DF).

TL;DR: It is concluded that the basal/progenitor cells create a pseudo-stratified, mucociliary NHBE model containing basal, serous, Clara, goblet and ciliated cells, reflective of the normal human bronchial epithelium (days 24-33 ALI culture).

TL;DR: The applications of filter-well technology for the advanced 3-D cell culture of human pulmonary cells are discussed and it is discussed that researchers can use microporous membranes for improved in vitro cell culture experiments.