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Zong-Wan Mao

Researcher at Sun Yat-sen University

Publications -  279
Citations -  10311

Zong-Wan Mao is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Chemistry & Catalysis. The author has an hindex of 50, co-authored 251 publications receiving 7958 citations. Previous affiliations of Zong-Wan Mao include Chinese Academy of Sciences & Peking University.

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Cyclometalated iridium(III) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents

TL;DR: In this article, four cyclometalated iridium(III)-β-carboline complexes with pH-responsive singlet oxygen (1O2) production and lysosome-specific imaging properties have been designed and synthesized.
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Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents.

TL;DR: Mechanism studies show that these complexes exert their anticancer efficacy by initiating a cascade of events related to mitochondrial dysfunction, and display up to 3 orders of magnitude higher cytotoxicity upon irradiation at 365 nm, which is so far the highest photocytotoxic responses reported for iridium complexes.
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G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs

TL;DR: This review will highlight the recent development of G 4-interacting metal complexes, termed G4-ligands, discussing their binding modes with G-quadruplex DNA and their potential to serve as anticancer drugs in the medical field.
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Insights into metalloenzyme microenvironments: biomimetic metal complexes with a functional second coordination sphere.

TL;DR: An overview of recent progress in non-covalent interactions in the second coordination sphere of metalloenzymes is provided and an introduction to native metall Koenzymes with an emphasis on thesecond coordination sphere is given.
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Multifunctional QD-based co-delivery of siRNA and doxorubicin to HeLa cells for reversal of multidrug resistance and real-time tracking.

TL;DR: Two CdSe/ZnSe QDs modified with β-CD coupled to L-Arg or L-His were used to simultaneously deliver doxorubicin (Dox) and siRNA targeting the MDR1 gene to reverse the multidrug resistance of HeLa cells.