Z
Zsolt Bikádi
Researcher at Hungarian Academy of Sciences
Publications - 71
Citations - 3385
Zsolt Bikádi is an academic researcher from Hungarian Academy of Sciences. The author has contributed to research in topics: Circular dichroism & Ligand (biochemistry). The author has an hindex of 29, co-authored 71 publications receiving 3127 citations. Previous affiliations of Zsolt Bikádi include University of Louisiana at Monroe & University of Washington.
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Journal ArticleDOI
Application of the PM6 semi-empirical method to modeling proteins enhances docking accuracy of AutoDock
Zsolt Bikádi,Eszter Hazai +1 more
TL;DR: The results demonstrate that the accuracy of determination of complex geometry using AutoDock 4 for docking calculation greatly increases with the use of quantum chemical partial charge calculation on both the ligands and proteins.
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Probing the binding of the flavonoid, quercetin to human serum albumin by circular dichroism, electronic absorption spectroscopy and molecular modelling methods.
TL;DR: It was found that quercetin shows extrinsic optical activity on interaction with HSA, and the molecule was found to be bound in the large hydrophobic cavity of subdomain IIA, which is able to help to stabilize the negatively charged ligand bound in non-planar conformation.
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Structure and Function of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)
TL;DR: Current knowledge of structure and function of this medically important ABC efflux drug transporter is reviewed to highlight its important role in the absorption, elimination, and tissue distribution of drugs and xenobiotics.
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Evaluation of drug–human serum albumin binding interactions with support vector machine aided online automated docking
TL;DR: The SVM model was integrated to a free, web-based prediction platform and the potential offered by the combined use of in silico calculation methods and experimental binding data is illustrated.
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Circular dichroism spectroscopic studies reveal pH dependent binding of curcumin in the minor groove of natural and synthetic nucleic acids
TL;DR: Evaluation of the spectral data and molecular modeling calculations suggested that curcumin, this dietary polyphenolic compound binds in the minor groove of the double helix, is also a promising molecular probe to study biologically important, pH and cation induced conformational polymorphisms of nucleic acids.