Z
Zunjian Zhang
Researcher at China Pharmaceutical University
Publications - 178
Citations - 2682
Zunjian Zhang is an academic researcher from China Pharmaceutical University. The author has contributed to research in topics: High-performance liquid chromatography & Mass spectrometry. The author has an hindex of 24, co-authored 171 publications receiving 2159 citations. Previous affiliations of Zunjian Zhang include Chinese Ministry of Education.
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Journal ArticleDOI
Enhancement of the capabilities of liquid chromatography-mass spectrometry with derivatization: general principles and applications.
TL;DR: This review presents an overview of derivatization-based LC-MS strategy over the past 10 years and covers both the general principles and applications in the fields of pharmaceutical and biomedical analysis, biomarker and metabolomic research, environmental analysis, and food-safety evaluation.
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Male reproductive toxicity and toxicokinetics of triptolide in rats.
Bin Ni,Zhenzhou Jiang,Xin Huang,Fengguo Xu,Rui Zhang,Zunjian Zhang,Yuan Tian,Tao Wang,Tian Zhu,Jing Liu,Luyong Zhang +10 more
TL;DR: Triptolide showed a non-linear kinetics profile and was rapidly absorbed but relatively slowly eliminated in the rats, and an accumulation of triptolide was seen in the testis, providing valuable information to estimate the reproductive risk of triPTolide in humans.
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Discovery of Metabolite Biomarkers for Acute Ischemic Stroke Progression
Peifang Liu,Ruiting Li,Anton Antonov,Lihua Wang,Wei Li,Yunfei Hua,Huimin Guo,Lijuan Wang,Peijia Liu,Lixia Chen,Yuan Tian,Fengguo Xu,Zunjian Zhang,Yulan Zhu,Yin Huang,Yin Huang +15 more
TL;DR: Mass-spectrometry-based metabolomics was utilized to characterize the metabolic features of the serum of patients with acute ischemic stroke to identify novel sensitive biomarkers for diagnosis and progression, providing insights for the development of new diagnostic tests and therapeutic approaches for AIS.
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Twin Derivatization Strategy for High-Coverage Quantification of Free Fatty Acids by Liquid Chromatography–Tandem Mass Spectrometry
TL;DR: A high-coverage liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was established for the quantification of FFAs in serum samples and indicates that twin derivatization-based LC-MS provides a more accurate view of global FFA alternation and has great application potential in the fields of targeted metabolomics.
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Simultaneous determination of metformin and rosiglitazone in human plasma by liquid chromatography/tandem mass spectrometry with electrospray ionization: application to a pharmacokinetic study.
TL;DR: The method described is precise and sensitive and has been successfully applied to the study of pharmacokinetics of compound metformin and rosiglitazone capsules in 12 healthy Chinese volunteers.