Zuqin Nie

TL;DR: To observe Myc target expression and function in a system where Myc is temporally and physiologically regulated, the transcriptomes and the genome-wide distributions of Myc, RNA polymerase II, and chromatin modifications were compared during lymphocyte activation and in ES cells as well.

TL;DR: In vitro recruitment of FBP and FIR to dynamically stressed c‐myc DNA paralleled the in vivo process, and engineering FUSE into episomal vectors predictably re‐programmed metallothionein‐promoter‐driven reporter expression.

TL;DR: It is shown that loss of CD47 permits sustained proliferation of primary murine endothelial cells, increases asymmetric division, and enables these cells to spontaneously reprogram to form multipotent embryoid body-like clusters.

TL;DR: Though a variety of functions have been attributed to the FBPs, it is proposed that they constitute a molecular regulatory kit that tunes the expression of shared targets through a common mechanism.

TL;DR: It is reported that BRD4 directly destabilizes MYC protein by phosphorylates MYC at Thr58, leading to MYC ubiquitination and degradation, thereby regulating MYC target genes and negatively regulates MYC levels, which is counteracted by ERK1 activation.