K
Keji Zhao
Researcher at National Institutes of Health
Publications - 237
Citations - 40822
Keji Zhao is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 85, co-authored 219 publications receiving 36556 citations. Previous affiliations of Keji Zhao include Johns Hopkins University & Howard Hughes Medical Institute.
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Journal ArticleDOI
High-resolution profiling of histone methylations in the human genome.
Artem Barski,Suresh Cuddapah,Kairong Cui,Tae-Young Roh,Dustin E. Schones,Zhibin Wang,Gang Wei,Iouri Chepelev,Keji Zhao +8 more
TL;DR: High-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing technology are generated.
Journal ArticleDOI
Combinatorial patterns of histone acetylations and methylations in the human genome
Zhibin Wang,Chongzhi Zang,Jeffrey A. Rosenfeld,Jeffrey A. Rosenfeld,Dustin E. Schones,Artem Barski,Suresh Cuddapah,Kairong Cui,Tae-Young Roh,Weiqun Peng,Michael Q. Zhang,Keji Zhao +11 more
TL;DR: The data suggest that a large number of histone modifications may act cooperatively to prepare chromatin for transcriptional activation and be associated with promoters and enhancers.
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Dynamic Regulation of Nucleosome Positioning in the Human Genome
Dustin E. Schones,Kairong Cui,Suresh Cuddapah,Tae-Young Roh,Artem Barski,Zhibin Wang,Gang Wei,Keji Zhao +7 more
TL;DR: It is found that nucleosome phasing relative to the transcription start sites is directly correlated to RNA polymerase II (Pol II) binding and the first nucleosomes downstream of a start site exhibits differential positioning in active and silent genes.
Journal ArticleDOI
Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes
TL;DR: In this paper, a genome-wide mapping of HATs and deacetylases binding on chromatin was performed and it was found that both are found at active genes with acetylated histones.
Journal ArticleDOI
Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells
Gang Wei,Lai Wei,Jinfang Zhu,Chongzhi Zang,Jane Hu-Li,Zhengju Yao,Kairong Cui,Yuka Kanno,Tae-Young Roh,Wendy T. Watford,Dustin E. Schones,Weiqun Peng,Hong-Wei Sun,William E. Paul,John J. O'Shea,Keji Zhao +15 more
TL;DR: Although modifications of signature-cytokine genes (Ifng, Il4, and Il17) partially conform to the expectation of lineage commitment, genes encoding transcription factors like Tbx21 exhibit a broad spectrum of epigenetic states, consistent with the demonstrated T-bet and interferon-gamma induction in nTreg cells.