Z
Zuzanna Nowakowska
Researcher at Jagiellonian University
Publications - 18
Citations - 268
Zuzanna Nowakowska is an academic researcher from Jagiellonian University. The author has contributed to research in topics: Porphyromonas gingivalis & Secretion. The author has an hindex of 8, co-authored 16 publications receiving 163 citations.
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Journal ArticleDOI
The outer-membrane export signal of Porphyromonas gingivalis type IX secretion system (T9SS) is a conserved C-terminal β-sandwich domain.
Iñaki de Diego,Miroslaw Ksiazek,Miroslaw Ksiazek,Danuta Mizgalska,Lahari Koneru,Przemyslaw Golik,B. Szmigielski,Magdalena Nowak,Zuzanna Nowakowska,Barbara Potempa,John A. Houston,Jan J. Enghild,Ida B. Thøgersen,Jinlong Gao,Ann H. Kwan,Jill Trewhella,Grzegorz Dubin,F. Xavier Gomis-Rüth,Ky-Anh Nguyen,Jan Potempa,Jan Potempa +20 more
TL;DR: The atomic structure of the CTD of gingipain B (RgpB) from P. gingivalis was solved and it was shown that despite the region being unstructured, it nevertheless is resistant to general proteolysis.
Journal ArticleDOI
Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis
Mariusz Madej,Joshua B. R. White,Joshua B. R. White,Zuzanna Nowakowska,Shaun Rawson,Shaun Rawson,Carsten Scavenius,Jan J. Enghild,Grzegorz Bereta,Karunakar R. Pothula,Ulrich Kleinekathoefer,Arnaud Baslé,Neil A. Ranson,Jan Potempa,Jan Potempa,Bert van den Berg +15 more
TL;DR: RagAB is identified as a dynamic, selective outer-membrane oligopeptide-acquisition machine that is essential for the efficient utilization of proteinaceous nutrients by P. gingivalis and solved its structure, elucidating that it works via a ‘pedal bin’ mechanism of nutrient uptake.
Journal ArticleDOI
Genes Contributing to Porphyromonas gingivalis Fitness in Abscess and Epithelial Cell Colonization Environments
Daniel P. Miller,Justin A Hutcherson,Yan Wang,Zuzanna Nowakowska,Jan Potempa,Jan Potempa,Deborah R. Yoder-Himes,David A. Scott,Marvin Whiteley,Richard J. Lamont +9 more
TL;DR: This study verifies the importance of several well-characterized putative virulence factors of P. gingivalis and identifies novel fitness determinants of the organism.
Journal ArticleDOI
Peptidylarginine deiminase from Porphyromonas gingivalis contributes to infection of gingival fibroblasts and induction of prostaglandin E2 -signaling pathway.
Katarzyna Gawron,Grzegorz Bereta,Zuzanna Nowakowska,K. Lazarz-Bartyzel,Lazarz M,B. Szmigielski,Danuta Mizgalska,Andrzej Buda,Joanna Koziel,Z Oruba,Maria Chomyszyn-Gajewska,Jan Potempa,Jan Potempa +12 more
TL;DR: The results implicate PPAD activity, but not PPAD itself, as an important factor for gingival fibroblast infection and activation of PGE2 synthesis, the latter of which may strongly contribute to bone resorption and eventual tooth loss.
Journal ArticleDOI
TIMP-1 association with collagen type I overproduction in hereditary gingival fibromatosis.
Katarzyna Gawron,Anna Ochała-Kłos,Zuzanna Nowakowska,Grzegorz Bereta,Katarzyna Łazarz-Bartyzel,Aleksander M. Grabiec,Paweł Plakwicz,Renata Górska,Andrzej Fertala,Maria Chomyszyn-Gajewska,Jan Potempa,Jan Potempa +11 more
TL;DR: It is reported that fibrosis in HGF gingival tissues is associated with increased synthesis of HSP47, and the shift in the TIMP-1/MMP-1 ratio identifiesIncreased synthesis of TIMp-1 as one of the processes associated with collagen I overproduction in H GF fibroblasts.