Academic Center for Education, Culture and Research

About: Academic Center for Education, Culture and Research is a nonprofit organization based out in Tehran, Iran. It is known for research contribution in the topics: Population & Mesenchymal stem cell. The organization has 1100 authors who have published 1244 publications receiving 19093 citations.

n-3 Fatty Acid Distribution of Commercial Fish Species Components

Abstract: For application of n-3 fatty acids, distribution of the fatty acid compositions of different parts of (head, tail, fins and skin = HTFS, liver, viscera and muscle tissue) five commercially important fish species from the Persian Gulf (Scomberomorus commersoni, Thunnus tonggol, Euthynnus affinis, Scomberomorus guttatus and Dussumieria acuta) as good sources of n-3 PUFA were studied The richest source of n-3 were HTFS in S guttatus and S commersoni, liver in S guttatus, total body of D acuta, liver of E affinis and T tonggol, followed by viscera of E affinis The content of these fatty acids were the same in viscera of tonggol, liver of S commersoni, and HTFS of E affinis Moreover, muscle of E affinis and HTFS of T tonggol and also muscle of S guttatus and T tonggol had the same n-3 contents as the viscera of S commersoni So, it was concluded that HTFS and viscera (which are discarded as residues) are as useful as muscle and liver and can be a source of economically available n-3 PUFA Muscle had the lowest proportion of n-3 in E affinis, T tonggol, and S guttatus in comparison with other organs of these fish species The highest n-3:n-6 ratio was observed in D acuta Finally, the cluster analysis showed that with respect to n-3 and other PUFA contents, HTFS of S commersoni and D acuta with S guttatus on the one hand, and HTFS of T tonggol and E affinis on the other hand were similar to each other In addition, viscera of S commersoni and S guttatus were similar followed by T tonggol and different from E affinis and D acuta In the case of muscle, T tonggol and S guttatus had good similarity followed by E affinis and had no significant similarity with S commersoni and D acuta With regard to liver, the highest similarity was observed between T tonggol and E affinis followed by D acuta and S guttatus, while S commersoni did not show similarity with the others

Cardiomyogenic differentiation of human adipose-derived mesenchymal stem cells transduced with Tbx20-encoding lentiviral vectors.

Abstract: Ischemic heart disease often results in myocardial infarction and is the leading cause of mortality and morbidity worldwide. Improvement in the function of infarcted myocardium is a main purpose of cardiac regenerative medicine. One possible way to reach this goal is via stem cell therapy. Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into a variety of cell types but display limited cardiomyogenic differentiation potential. Members of the T-box family of transcription factors including Tbx20 play important roles in heart development and cardiomyocyte homeostasis. Therefore, in the current study, we investigated the potential of Tbx20 to enhance the cardiomyogenic differentiation of human adipose-derived MSCs (ADMSCs). Human ADMSCs were transduced with a bicistronic lentiviral vector encoding Tbx20 (murine) and the enhanced green fluorescent protein (eGFP) and analyzed 7 and 14 days post transduction. Transduction of human ADMSCs with this lentiviral vector increased the expression of the cardiomyogenic differentiation markers ACTN1, TNNI3, ACTC1, NKX2.5, TBX20 (human), and GATA4 as revealed by RT-qPCR. Consistently, immunocytological results showed elevated expression of α-actinin and cardiac troponin I in these cells in comparison to the cells transduced with control lentiviral particles coding for eGFP alone. Accordingly, forced expression of Tbx20 exerts cardiomyogenic effects on human ADMSCs by increasing the expression of cardiomyogenic differentiation markers at the RNA and protein level.

Seroepidemiology of HTLV-1 and HTLV-2 Infection in Neyshabur City, North-Eastern Iran, during 2010-2014.

Abstract: BACKGROUND Retroviruses of human T-lymphotropic viruses (HTLV-1 and HTLV-2) have been demonstrated to be endemic in the north-eastern region of Iran. This study was aimed to determine the HTLV-1 and HTLV-2 prevalence among healthy individuals in Neyshabur City during 2010-2014. METHODS A total of 8054 blood samples were collected from healthy participants in Neyshabur, North-Eastern Iran. The blood samples were screened for the presence of specific antibodies against HTLV-1 and HTLV-2 by using ELISA according to the manufacturer's instructions. RESULTS The overall seropositivity rate for HTLV-1 and HTLV-2 was found to be 6.55% (528 out of 8054) among participants. CONCLUSION Both HTLV-1 and HTLV-2 were demonstrated to be at a high rate in healthy individuals. However, a smaller number of asymptomatic carriers were found in this study, as compared to those identified in previous investigations in the city.

The pattern of muscle involvement in ulnar neuropathy at the elbow

Abstract: Objective: To determine the pattern of muscle involvement in patients with ulnar neuropathy at the elbow. Materials and Methods: This study evaluated all patients referred for upper limb electrodiagnostic study (EDX) during 2007-2011 and included. patients with clinical signs and symptoms of ulnar neuropathy at the elbow. All patients had nerve conduction studies (NCS) for ulnar neuropathy. Needle electromyography (EMG) of four ulnar innervated muscles, flexor carpi ulnaris (FCU), flexor digitrom profoundus (FDP), first dorsal interosseous (FDI) and abductor digiti minimi (ADM)) was evaluated. Results: During the study period 34 (23 males and 11 females) patients were diagnosed with ulnar neuropathy at the elbow and three of them had bilateral involvement. Muscle involvement by EMG was as follows: FDI: 91.9%, ADM: 91.3%, FCU: 64.9% and FDP: 56.8%. Conclusion: In this study, EMG abnormalities of nerve damage were presented more commonly in the FCU muscle than in the FDP in patients with ulnar nerve lesion at the elbow.