Institution
Aintree University Hospitals NHS Foundation Trust
Healthcare•Liverpool, United Kingdom•
About: Aintree University Hospitals NHS Foundation Trust is a healthcare organization based out in Liverpool, United Kingdom. It is known for research contribution in the topics: Population & Cancer. The organization has 688 authors who have published 603 publications receiving 36207 citations. The organization is also known as: Aintree Hospitals NHS Trust & Aintree Hospitals National Health Service Trust.
Papers published on a yearly basis
Papers
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TL;DR: The most highly ranked research questions related to treatment pathways, operative strategies and the impact of HPB procedures on quality of life, particularly for malignant disease were identified in this paper.
Abstract: BACKGROUND
Research prioritisation can help identify clinically relevant questions and encourage high-quality, patient-centred research. Delphi methodology aims to develop consensus opinion within a group of experts, with recent Delphi projects helping to define the research agenda and funding within several medical and surgical specialties.
METHODS
All members of the Association of Upper Gastrointestinal Surgeons (AUGIS) were asked to submit clinical research questions using an online survey (Phase 1). Two consecutive rounds of Delphi prioritisation by multidisciplinary HPB healthcare professionals (Phase 2) were undertaken to establish a final list of the most highly prioritised research questions. A multidisciplinary steering committee analysed the results of each phase.
RESULTS
Ninety-three HPB-focussed questions were identified in Phase 1, with thirty-seven questions of sufficient priority to enter a further prioritisation round. A final group of 11 questions considered highest priority were identified. The most highly ranked research questions related to treatment pathways, operative strategies and the impact of HPB procedures on quality of life, particularly for malignant disease.
CONCLUSION
Expert consensus has identified research priorities within the UK HPB surgical community over the coming years. Funding applications, to establish well-designed, high quality collaborative research are now required to address these questions.
12 citations
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TL;DR: This study shows that adenotonsillectomy significantly reduces the apnoeic episodes in children with cardiac pathology but does not abolish it, and there was significant overall improvement in the baseline oxygen saturation after surgery.
12 citations
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TL;DR: A panel of international experts reviewing the literature and drafting a consensus document on the unique peculiarities of anesthesia in older cancer patients prompted the International Society of Geriatric Oncology to put together a panel of global experts.
12 citations
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TL;DR: There is a significantly wide variety of current practices for antimetabolite administration and bleb needling within the UK and Ireland and this may be influenced by a glaucoma surgeon’s specific experience and audit results as well as particular clinical set-up, availability of antimetabolic and clinic room space.
Abstract: Aims To evaluate, describe and quantify the diversity in postoperative antimetabolite administration and bleb needling practices among glaucoma specialists performing trabeculectomy surgery within the UK and Ireland. Methods A cross-sectional online survey was distributed to all consultant glaucoma specialists who are on the United Kingdom and Eire Glaucoma Society (UKEGS) contact list. Participants were asked specific questions about their current practices for post-trabeculectomy antimetabolite administration followed by questions directly related to bleb needling procedures. Results 60 (83%) of UKEGS glaucoma subspecialty consultants completed the survey. 70% of respondents administered 5-fluorouracil (5-FU) in their clinic room while 30% used a separate treatment room. Doses of 5-FU varied considerably but 70% used 5 mg as standard. Techniques used to reduce corneal toxicity included precipitation with amethocaine (44%) or benoxinate (14%), saline wash (14%) and modified injection technique (8%). Topical antibiotics and/or betadine were used to prevent infection following 5-FU injection in just over 50%. Bleb needling was exclusively performed in operating theatre by 56% of respondents and solely at the slit lamp in the clinic room by 12%. A further 30% used a combination of both theatre and outpatient clinic rooms. Anti-metabolites used were 5-FU (72%) and mitomycin C (22%) with 12% using either of the two substances. Conclusions There is a significantly wide variety of current practices for antimetabolite administration and bleb needling within the UK and Ireland. This may be influenced by a glaucoma surgeon’s specific experience and audit results as well as particular clinical set-up, availability of antimetabolite and clinic room space.
12 citations
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TL;DR: Meta-analysis of data demonstrated that using cardiopulmonary ultrasound (CPUS) was 91% sensitive and 81% specific for pulmonary embolism diagnosis compared to diagnostic standard CTPA, which is useful in areas where CTPA is unavailable or unsuitable.
Abstract: Objectives
Computed tomography pulmonary angiography (CTPA) is the diagnostic standard for pulmonary embolism (PE), but is unavailable in many low resource settings. We evaluated the evidence for point of care ultrasound as an alternative diagnostic.
Methods
Using a PROSPERO-registered, protocol-driven strategy (https://www.crd.york.ac.uk/PROSPERO, ID = CRD42018099925), we searched MEDLINE, EMBASE, and CINHAL for observational and clinical trials of cardiopulmonary ultrasound (CPUS) for PE. We included English-language studies of adult patients with acute breathlessness, reported according to PRISMA guidelines published in the last two decades (January 2000 to February 2020). The primary outcome was diagnostic accuracy of CPUS compared to reference standard CTPA for detection of PE in acutely breathless adults.
Results
We identified 260 unique publications of which twelve met all inclusion criteria. Of these, seven studies (N = 3872) were suitable for inclusion in our meta-analysis for diagnostic accuracy (two using CTPA and five using clinically derived diagnosis criterion). Meta-analysis of data demonstrated that using cardiopulmonary ultrasound (CPUS) was 91% sensitive and 81% specific for pulmonary embolism diagnosis compared to diagnostic standard CTPA. When compared to clinically derived diagnosis criterion, CPUS was 52% sensitive and 92% specific for PE diagnosis. We observed substantial heterogeneity across studies meeting inclusion criteria (I2 = 73.5%).
Conclusions
Cardiopulmonary ultrasound may be useful in areas where CTPA is unavailable or unsuitable. Interpretation is limited by study heterogeneity. Further methodologically rigorous studies comparing CPUS and CTPA are important to inform clinical practice.
12 citations
Authors
Showing all 691 results
Name | H-index | Papers | Citations |
---|---|---|---|
Edward T. Bullmore | 165 | 746 | 112463 |
Reza Malekzadeh | 118 | 900 | 139272 |
Peter M.A. Calverley | 80 | 363 | 38558 |
John P.H. Wilding | 72 | 371 | 23486 |
Derek Lowe | 68 | 347 | 15051 |
Simon N. Rogers | 59 | 373 | 13915 |
Robert J. Moots | 54 | 266 | 10309 |
James S. Brown | 50 | 118 | 7046 |
Raimundas Lunevicius | 48 | 117 | 53448 |
Robert Jones | 46 | 262 | 16459 |
Julia A. Woolgar | 46 | 97 | 6469 |
Michael D. Jenkinson | 40 | 184 | 4214 |
Richard Shaw | 39 | 168 | 5023 |
Daniel J. Cuthbertson | 38 | 154 | 5184 |
Timothy R. Helliwell | 36 | 140 | 4908 |