Institution
Albert Schweitzer Hospital
Healthcare•Lambaréné, Gabon•
About: Albert Schweitzer Hospital is a healthcare organization based out in Lambaréné, Gabon. It is known for research contribution in the topics: Population & Plasmodium falciparum. The organization has 1029 authors who have published 1568 publications receiving 43581 citations.
Papers published on a yearly basis
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TL;DR: The new 2017 recommendations downgrade and limit the use of the current BVS to experienced centres within dedicated registries using the updated implantation protocol and advise the prolonged usage of DAPT.
Abstract: Background To eliminate some of the potential late limitations of permanent metallic stents, the bioresorbable coronary stents or ‘bioresorbable vascular scaffolds’ (BVS) have been developed. Methods We reviewed all currently available clinical data on BVS implantation. Results Since the 2015 position statement on the appropriateness of BVS in percutaneous coronary interventions, several large randomised trials have been presented. These have demonstrated that achieving adequate 1 and 2 year outcomes with these first-generation BVS is not straightforward. These first adequately powered studies in non-complex lesions showed worse results if standard implan- tation techniques were used for these relatively thick scaffolds. Post-hoc analyses hypothesise that outcomes similar to current drug-eluting stents are still possible if aggressive lesion preparation, adequate sizing and high-pressure postdilatation are implemented rigorously. As long as this has not been confirmed in prospective studies the usage should be restricted to experienced centres with continuous outcome monitoring. For more complex lesions, results are even more disappointing and usage should be discouraged. When developed, newer generation scaffolds with thinner struts or faster resorption rates are expected to improve outcomes. In the meantime prolonged dual antiplatelet therapy (DAPT, beyond one year) is recommended in an individu-alised approach for patients treated with current generation BVS. Conclusion The new 2017 recommendations downgrade and limit the use of the current BVS to experienced centres within dedicated registries using the updated implantation protocol and advise the prolonged usage of DAPT. In line with these recommendations the manufacturer does not supply devices to the hospitals without such registries in place.
10 citations
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University of Amsterdam1, Erasmus University Rotterdam2, Albert Schweitzer Hospital3, VU University Amsterdam4, Norwegian University of Science and Technology5, Aalborg University6, Radboud University Nijmegen7, VU University Medical Center8, Stavanger University Hospital9, Odense University Hospital10
TL;DR: The final analysis of induction therapy and preliminary results of the randomization phase of the study are reported and frailty, frailty (unfit or frail) or high cytogenetic risk did not affect the rate and quality of response.
10 citations
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University Medical Center Groningen1, VU University Amsterdam2, Leiden University Medical Center3, Maastricht University4, University of Amsterdam5, Utrecht University6, Medisch Spectrum Twente7, Erasmus University Rotterdam8, Maastricht University Medical Centre9, Bosch10, Albert Schweitzer Hospital11
TL;DR: Short-term postoperative outcomes were better after combined resection and ablation in patients with colorectal liver metastases in the Netherlands, attributed to avoiding complications associated with major hepatectomy.
Abstract: Background Combining resection and thermal ablation can improve short-term postoperative outcomes in patients with colorectal liver metastases (CRLM). This study assessed nationwide hospital variation and short-term postoperative outcomes after combined resection and ablation. Methods In this population-based study, all CRLM patients who underwent resection in the Netherlands between 2014 and 2018 were included. After propensity score matching for age, ASA-score, Charlson-score, diameter of largest CRLM, number of CRLM and earlier resection, postoperative outcomes were compared. Postoperative complicated course (PCC) was defined as discharge after 14 days or a major complication or death within 30 days of surgery. Results Of 4639 included patients, 3697 (80%) underwent resection and 942 (20%) resection and ablation. Unadjusted percentage of patients who underwent resection and ablation per hospital ranged between 4 and 44%. Hospital variation persisted after case-mix correction. After matching, 734 patients remained in each group. Hospital stay (median 6 vs. 7 days, p = 0.011), PCC (11% vs. 14.7%, p = 0.043) and 30-day mortality (0.7% vs. 2.3%, p = 0.018) were lower in the resection and ablation group. Differences faded in multivariable logistic regression due to inclusion of major hepatectomy. Conclusion Significant hospital variation was observed in the Netherlands. Short-term postoperative outcomes were better after combined resection and ablation, attributed to avoiding complications associated with major hepatectomy.
10 citations
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TL;DR: The promising findings with the use of hs-cTnT only call for new initiatives to study its impact on efficacious CMR imaging in a larger HC population, either with or without additional use of clinical variables.
Abstract: In nonhigh risk patients with hypertrophic cardiomyopathy (HC), the presence of extensive late gadolinium enhancement (LGEext) at cardiovascular magnetic resonance (CMR) imaging has been proposed as a risk modifier in the decision process for implantable cardioverter defibrillator implantation. With a pretest risk of about 10%, a strategy that alters the likelihood of LGEext could markedly affect efficacious CMR imaging. Our aim was to study the potential of clinical variables and biomarkers to predict LGEext. In 98 HC patients without any clear indication for implantable cardioverter defibrillator implantation, we determined the discriminative values of a set of clinical variables and a panel of biomarkers (hs-cTnT, NTproBNP, GDF-15, and Gal-3, CICP) for LGEext, that is, LGE ≥15% of the left ventricular mass. LGEext was present in 10% (10/98) of patients. The clinical prediction model contained a history of nonsustained ventricular tachycardia, maximal wall thickness and reduced systolic function (c-statistic: 0.868, p
10 citations
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TL;DR: This research presents a meta-analysis of 124 cases of central giant cell granuloma found at the University of Rome’s SAPIENZA during the period of May 21 to 29, 2013, which confirmed the presence of the disease-causing cells called “plaques” in the immune system.
Abstract: *Department of Radiological Sciences, Oncology and Pathology, “SAPIENZA” University of Rome, I.C.O.T. Hospital, Latina, Italy, †Pathology Unit,Department of Medical Surgical Sciences and Biotechnologies, “SAPIENZA” University of Rome, I.C.O.T. Hospital, Latina, Italy, ‡School of Radiology,University of Genoa, Genoa, Italy, §Pelvic Floor Unit, I Department of Surgery, Regional Hospital, Treviso, Italy, ¶Unit of Gastroenterology, AUSLBologna Maggiore Hospital, Bologna, Italy, **Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, TheNetherlands and ††Department of Radiology, Albert Schweitzer Hospital, Dordrecht, The Netherlands
10 citations
Authors
Showing all 1029 results
Name | H-index | Papers | Citations |
---|---|---|---|
Peter G. Kremsner | 87 | 739 | 32544 |
Andreas Voss | 83 | 757 | 28426 |
Sandrine Florquin | 72 | 372 | 18406 |
Maria Yazdanbakhsh | 68 | 322 | 19397 |
Sanjeev Krishna | 67 | 285 | 18547 |
Martin P. Grobusch | 57 | 497 | 14024 |
Adrian J. F. Luty | 53 | 114 | 7094 |
Dirk G. Struijk | 53 | 201 | 9182 |
T. Peter Kingham | 52 | 298 | 8905 |
Michiel G. H. Betjes | 51 | 229 | 8689 |
Benjamin Mordmüller | 47 | 195 | 8319 |
Saadou Issifou | 45 | 109 | 6458 |
Steffen Borrmann | 44 | 104 | 7736 |
Bertrand Lell | 42 | 135 | 6582 |
Ayola A. Adegnika | 39 | 166 | 5433 |