Institution
Edgewood Chemical Biological Center
About: Edgewood Chemical Biological Center is a based out in . It is known for research contribution in the topics: Adsorption & Loam. The organization has 483 authors who have published 738 publications receiving 25525 citations.
Topics: Adsorption, Loam, Mass spectrometry, Genome, Gene
Papers published on a yearly basis
Papers
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TL;DR: DART has demonstrated success in sampling hundreds of chemicals, including chemical agents and their signatures, pharmaceutics, metabolites, peptides and oligosaccharides, synthetic organics, organometallics, drugs of abuse, explosives, and toxic industrial chemicals.
Abstract: A new ion source has been developed for rapid, noncontact analysis of materials at ambient pressure and at ground potential. The new source, termed DART (for “Direct Analysis in Real Time”), is based on the reactions of electronic or vibronic excited-state species with reagent molecules and polar or nonpolar analytes. DART has been installed on a high-resolution time-of-flight mass spectrometer (TOFMS) that provides improved selectivity and accurate elemental composition assignment through exact mass measurements. Although DART has been applied to the analysis of gases, liquids, and solids, a unique application is the direct detection of chemicals on surfaces without requiring sample preparation, such as wiping or solvent extraction. DART has demonstrated success in sampling hundreds of chemicals, including chemical agents and their signatures, pharmaceutics, metabolites, peptides and oligosaccharides, synthetic organics, organometallics, drugs of abuse, explosives, and toxic industrial chemicals. These s...
2,269 citations
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TL;DR: High resolution crystal structures of human AChE, alone and in complexes with drug ligands; donepezil, an Alzheimer's disease drug, binds differently to human A cholinesterase than it does to Torpedo A ChE.
Abstract: Human acetylcholinesterase (AChE) is a significant target for therapeutic drugs. Here we present high resolution crystal structures of human AChE, alone and in complexes with drug ligands; donepezil, an Alzheimer’s disease drug, binds differently to human AChE than it does to Torpedo AChE. These crystals of human AChE provide a more accurate platform for further drug development than previously available.
842 citations
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TL;DR: In this paper, artificial neural networks are used to approximate light scattering by multilayer nanoparticles. But the network needs to be trained on only a small sampling of the data to approximate the simulation to high precision.
Abstract: We propose a method to use artificial neural networks to approximate light scattering by multilayer nanoparticles. We find that the network needs to be trained on only a small sampling of the data to approximate the simulation to high precision. Once the neural network is trained, it can simulate such optical processes orders of magnitude faster than conventional simulations. Furthermore, the trained neural network can be used to solve nanophotonic inverse design problems by using back propagation, where the gradient is analytical, not numerical.
576 citations
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TL;DR: The present review summarizes the state of the art in molecular recognition of biowarfare agents and other pathogens and emphasizes the advantages of using particular types of reagents for a given target and the challenges faced by military and civilian defense components in the rapid and accurate detection and identification of harmful agents in the field.
555 citations
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TL;DR: In this paper, the authors show that there are significant changes in chemical and thermal stability of Zr6O4(OH)4 MOFs with the incorporation of different organic linkers.
Abstract: Metal–organic frameworks (MOFs) with the Zr6O4(OH)4 secondary building unit (SBU) have been of particular interest for potential commercial and industrial uses because they can be easily tailored and are reported to be chemically and thermally stable. However, we show that there are significant changes in chemical and thermal stability of Zr6O4(OH)4 MOFs with the incorporation of different organic linkers. As the number of aromatic rings is increased from one to two in 1,4-benzene dicarboxylate (UiO-66, ZrMOF–BDC) and 4,4′-biphenyl dicarboxylate (UiO-67, ZrMOF–BPDC), the Zr6O4(OH)4 SBU becomes more susceptible to chemical degradation by water and hydrochloric acid. Furthermore, as the linker is replaced with 2,2′-bipyridine-5,5′-dicarboxylate (ZrMOF–BIPY) the chemical stability decreases further as the MOF is susceptible to chemical breakdown by protic chemicals such as methanol and isopropanol. The results reported here bring into question the superior structural stability of the UiO-67 analogs as reported by others. Furthermore, the degradation mechanisms proposed here may be applied to other classes of MOFs containing aromatic dicarboxylate organic linkers, in order to predict their structural stability upon exposure to solvents.
535 citations
Authors
Showing all 483 results
Name | H-index | Papers | Citations |
---|---|---|---|
David S. Wishart | 108 | 523 | 76652 |
Liang Li | 69 | 367 | 17347 |
Qian Du | 62 | 555 | 18872 |
Chein-I Chang | 56 | 447 | 18068 |
Gregory W. Peterson | 41 | 153 | 6860 |
Peter de B. Harrington | 35 | 195 | 4092 |
Rosalba Saija | 33 | 123 | 3366 |
Mónica J.B. Amorim | 32 | 149 | 3092 |
James J. Valdes | 32 | 117 | 3817 |
Daniel Barker | 30 | 133 | 11609 |
Jared B. DeCoste | 30 | 67 | 4754 |
James O. Jensen | 29 | 217 | 2833 |
Maria Antonia Iatì | 27 | 87 | 2788 |
George W. Wagner | 27 | 90 | 3464 |
Steven D. Lacey | 27 | 39 | 4317 |