Institution
Hallym University
Education•Chuncheon, South Korea•
About: Hallym University is a education organization based out in Chuncheon, South Korea. It is known for research contribution in the topics: Population & Medicine. The organization has 10605 authors who have published 18891 publications receiving 302498 citations.
Topics: Population, Medicine, Cancer, Stroke, Odds ratio
Papers published on a yearly basis
Papers
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TL;DR: The data indicate that MTA1 is closely associated with microvascular invasion, frequent postoperative recurrence, and poor survival of HCC patients, especially in those with HBV‐associated HCC.
85 citations
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TL;DR: The latter new interpretive guideline has enhanced detection of ESBLs in clinical isolates of Klebsiella spp.
Abstract: We evaluated highly sensitive methods using boronic acid (BA) to detect extended-spectrum β-lactamase (ESBL) production. A total of 182 clinical isolates of Klebsiella spp. (n = 118) and Escherichia coli (n = 64) were analyzed: 62 harbored only ESBLs, 80 harbored both ESBLs and plasmid-mediated AmpC β-lactamases (pAmpCs), and 40 harbored only pAmpCs. The CLSI confirmatory test detected all isolates that produce only ESBLs but detected 85% of isolates that produce both enzymes. When a ≥5-mm increase in the zone diameter of either the cefotaxime (CTX) or the ceftazidime (CAZ) disk in the presence of both clavulanic acid (CA) and BA was considered to be a positive result, the test detected all isolates that harbor ESBLs (± pAmpCs) but showed frequent false-positive results (50%) for isolates that produce only pAmpCs. Meanwhile, when a ≥3-mm increase in the zone diameter of either the CTX/BA or the CAZ/BA disk in the presence of CA was considered to be a positive result, the test also detected all isolates that harbor ESBLs (± pAmpCs) and showed less frequent false-positive results (5%) in isolates that produce only pAmpCs. The latter new interpretive guideline has enhanced detection of ESBLs in clinical isolates of Klebsiella spp. and Escherichia coli and allowed detection of an ESBL even when potentially masked by a pAmpC.
85 citations
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TL;DR: It is shown that mTOR acts as a critical relay molecule downstream of PI3K/AKT and upstream of p53 in PICS, and it is found that PTEN depletion induces cellular senescence via p53-p21 signaling without triggering DNA damage response.
Abstract: Loss of PTEN, the major negative regulator of the PI3K/AKT pathway induces a cellular senescence as a failsafe mechanism to defend against tumorigenesis, which is called PTEN-loss-induced cellular senescence (PICS). Although many studies have indicated that the mTOR pathway plays a critical role in cellular senescence, the exact functions of mTORC1 and mTORC2 in PICS are not well understood. In this study, we show that mTOR acts as a critical relay molecule downstream of PI3K/AKT and upstream of p53 in PICS. We found that PTEN depletion induces cellular senescence via p53-p21 signaling without triggering DNA damage response. mTOR kinase, a major component of mTORC1 and mTORC2, directly binds p53 and phosphorylates it at serine 15. mTORC1 and mTORC2 compete with MDM2 and increase the stability of p53 to induce cellular senescence via accumulation of the cell cycle inhibitor, p21. In embryonic fibroblasts of PTEN-knockout mice, PTEN deficiency also induces mTORC1 and mTORC2 to bind to p53 instead of MDM2, leading to cellular senescence. These results collectively demonstrate for the first time that mTOR plays a critical role in switching cells from proliferation signaling to senescence signaling via a direct link between the growth-promoting activity of AKT and the growth-suppressing activity of p53.
85 citations
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TL;DR: Results demonstrate that IL-18 has a critical role as a survival factor for B16F10 melanoma cells.
Abstract: It has been known that melanoma cells can suppress the immune system by
the Fas ligand. The present study investigated whether interleukin
(IL)-18, which can enhance Fas ligand expression, is produced by B16F10
melanoma cells and is involved in immune escape of tumor cells.
Immunohistology, reverse transcription-PCR, intracellular
fluorescence-activated cell-sorting analysis, and immunoblotting
demonstrated that melanoma cells express IL-18. C57BL/6 splenocytes
cultured with culture supernatants of B16F10 melanoma cells enhanced
IFN-γ production, which was blocked by anti-IL-18 antibody,
indicating that IL-18 in the culture supernatants is functional. In
addition to IL-18, the IL-18 receptor was also detected in B16F10
melanoma cells, suggesting a role of this cytokine in regulating the
functions of B16F10 melanoma cells. The functional effect of IL-18 on
B16F10 melanoma cells was shown by reduction of Fas ligand expression
in cells treated with anti-IL-18 antibody or transfected with IL-18
antisense cDNA. In addition, the same treatments decreased
intracellular reactive oxygen intermediate levels in B16F10 melanoma
cells, indicating that IL-18 regulates reactive oxygen intermediate
production, which is involved in Fas ligand expression. Furthermore,
transfection of IL-18 antisense cDNA into melanoma cells increased the
susceptibility of tumor cells to natural killer cells in
vitro . When IL-18 antisense transfectants were implanted into
syngeneic mice, severe reduction of tumor cell growth was observed with
concomitant infiltrated natural killer cells in the tumor area. Taken
together, these results demonstrate that IL-18 has a critical role as a
survival factor for B16F10 melanoma cells.
85 citations
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TL;DR: It is shown that aqueous extract of IRFRC inhibits cell proliferation and stimulates apoptosis in HT-29 cells, and that this may be mediated by its ability to activate the caspase-3 pathway.
85 citations
Authors
Showing all 10682 results
Name | H-index | Papers | Citations |
---|---|---|---|
Christos S. Mantzoros | 124 | 712 | 55587 |
Pak H. Chan | 99 | 330 | 35997 |
Nosratola D. Vaziri | 98 | 708 | 34586 |
Christopher I. Shaffrey | 87 | 805 | 27862 |
Eric J. Jacobs | 86 | 263 | 23485 |
Hyun Lee | 83 | 512 | 52596 |
Amanda G. Thrift | 73 | 316 | 67787 |
Young-Min Kim | 71 | 1314 | 26916 |
Young-Bum Kim | 70 | 447 | 22433 |
William F. Fearon | 66 | 309 | 23956 |
Sung Hoon Noh | 62 | 440 | 15255 |
Hyo Keun Lim | 62 | 276 | 11816 |
Hyoung Gon Lee | 60 | 200 | 11773 |
Young Guen Kwon | 60 | 231 | 12379 |
Sin-Ho Jung | 56 | 317 | 12143 |