Y
Young-Bum Kim
Researcher at Beth Israel Deaconess Medical Center
Publications - 449
Citations - 24116
Young-Bum Kim is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Communications system & Telecommunications link. The author has an hindex of 70, co-authored 447 publications receiving 22433 citations. Previous affiliations of Young-Bum Kim include Charles R. Drew University of Medicine and Science & Gachon University.
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Journal ArticleDOI
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase.
Yasuhiko Minokoshi,Young-Bum Kim,Odile D. Peroni,Lee G.D. Fryer,Corinna Müller,David Carling,Barbara B. Kahn +6 more
TL;DR: It is shown that leptin selectively stimulates phosphorylation and activation of the α2 catalytic subunit of AMPK (α2 AMPK) in skeletal muscle, thus establishing a previously unknown signalling pathway for leptin, and identifying AMPK as a principal mediator of the effects of leptin on fatty-acid metabolism in muscle.
Journal ArticleDOI
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Yasuhiko Minokoshi,Thierry Alquier,Noboru Furukawa,Young-Bum Kim,Anna Lee,Bingzhong Xue,James Mu,Fabienne Foufelle,Pascal Ferré,Morris J. Birnbaum,Bettina J. Stuck,Barbara B. Kahn +11 more
TL;DR: Hypothalamic AMPK plays a critical role in hormonal and nutrient-derived anorexigenic and orexigenic signals and in energy balance, and inhibition of hypothalamic AM PK is necessary for leptin's effects on food intake and body weight, as constitutively active AMPK blocks these effects.
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Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice
Lori D. Klaman,Olivier Boss,Odile D. Peroni,Jason K. Kim,Jennifer L. Martino,Janice M. Zabolotny,Nadeem Moghal,Margaret Lubkin,Young-Bum Kim,Arlene H. Sharpe,Alain Stricker-Krongrad,Gerald I. Shulman,Benjamin G. Neel,Barbara B. Kahn +13 more
TL;DR: PTP-1B is identified as a major regulator of energy balance, insulin sensitivity, and body fat stores in vivo and is implicated in the regulation of insulin action and signal transduction pathways.
Journal ArticleDOI
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
E. Dale Abel,Odile D. Peroni,Jason K. Kim,Young-Bum Kim,Olivier Boss,Ed Hadro,Timo Minnemann,Gerald I. Shulman,Barbara B. Kahn +8 more
TL;DR: Downregulation of GLUT4 and glucose transport selectively in adipose tissue can cause insulin resistance and thereby increase the risk of developing diabetes, as well as developing glucose intolerance and hyperinsulinaemia.
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Uncoupling Protein-2 Negatively Regulates Insulin Secretion and Is a Major Link between Obesity, β Cell Dysfunction, and Type 2 Diabetes
Chen-Yu Zhang,Gyorgy Baffy,Gyorgy Baffy,Pascale Perret,Stefan Krauss,Odile D. Peroni,Danica Grujic,Thilo Hagen,Antonio Vidal-Puig,Olivier Boss,Young-Bum Kim,Xin Xiao Zheng,Michael B. Wheeler,Gerald I. Shulman,Catherine B. Chan,Bradford B. Lowell +15 more
TL;DR: Results establish UCP2 as a key component of β cell glucose sensing, and as a critical link between obesity, β cell dysfunction, and type 2 diabetes.