Hallym University

About: Hallym University is a education organization based out in Chuncheon, South Korea. It is known for research contribution in the topics: Population & Medicine. The organization has 10605 authors who have published 18891 publications receiving 302498 citations.

Effects of ambient particulate matter on peak expiratory flow rates and respiratory symptoms of asthmatics during Asian dust periods in Korea

Abstract: Objective: Dust generating events frequently produce ambient dust particles that are less than 10 µm in diameter, and these have been linked to adverse effects in the general population. However, the evidence linking these particles to adverse effects on the airways of asthmatic individuals is limited. The objective of this study was to investigate the possible adverse effects of Asian dust events on the respiratory functions and symptoms of subjects with bronchial asthma. Methodology: From March to June 2002, individuals were enrolled who had been diagnosed as having asthma by bronchial challenge or by their bronchodilator response. The patients were divided into three groups according to asthma severity: mild, moderate and severe. Patients with other major disease states were excluded. Patients completed twice-daily diaries monitoring PEF, respiratory symptoms, and daily activities. The daily and hourly mean levels of particulate matter <10 µm in diameter (PM10), as well as nitrogen dioxide (NO2), sulphur dioxide (SO2), ozone (O3) and carbon monoxide (CO) were measured at 10 monitoring sites in Incheon, Korea. Results: Dust events occurred 14 times during the study period. On dusty days there were increased levels of PM10, decreased levels of NO2 and SO2, and no change in the CO levels, compared to the levels on control days. An increase in PM10 concentration was associated with increases in PEF variability of >20% (P 20% between the morning and evening values and a relative risk of 1.05 (95% CI, 0.89–1.24) in all subjects. Conclusions: This study provides evidence that Asian dust events are impacting on the respiratory symptoms of subjects with bronchial asthma, and ambient air pollution, particularly elevated PM10, might be one of the aggravating factors.