Showing papers by "Jordan University of Science and Technology published in 1988"
TL;DR: An antiswing control system which adopts a feedback control to specify the crane speed at every moment and the gain matrix is chosen such that a desired rate of decay of the swing angles is obtained.
Abstract: In this paper, we derive a nonlinear dynamical model for an overhead crane. The model takes into account simultaneous travel and transverse motions of the crane. The aim is to transport an object along a specified transport route in such a way that the swing angles are suppressed as quickly as possible. We develop an antiswing control system which adopts a feedback control to specify the crane speed at every moment. The gain matrix is chosen such that a desired rate of decay of the swing angles is obtained. The model and control scheme are simulated on a digital computer and the results prove that the feedback control works well.
192 citations
TL;DR: In this article, the proximity of the subspaces spanned by the individual columns of the B matrix to the one-dimensional A t -invariant subspace can be used as measures of modal controllability of a linear model.
89 citations
Patent•
28 Jan 1988TL;DR: In this article, an assembly-type barricade comprising a base stand and an upstanding wall both of which are nearly rectangular parallelpipedal, is presented, where a protruding means is provided in one of the bases and the upright wall in the other.
Abstract: An assembly-type barricade comprising a base stand and an upstanding wall both of which are nearly rectangular parallelpipedal. Protruding means is provided in one of the base stand and the upright wall, and receiving means is provided in the other. By positioning the protruding means in the receiving means, the upright wall is detachably mounted on the base stand.
32 citations
TL;DR: A rapid high performance liquid chromatographic (HPLC) method for the analysis of caffeine in plasma and saliva is described.
Abstract: A rapid high performance liquid chromatographic (HPLC) method for the analysis of caffeine in plasma and saliva is described. Samples of saliva and plasma were purified using zinc sulphate solution as protein precipitant. The supernatant was injected directly onto the column. The mobile phase consisted of ammonium acetate buffer:acetonitrile:methanol (82:15:3, v/v). Measurements were carried out at 254 nm. Acetanilide was used as the internal standard and analysis was completed in 10 min. No interference from endogenous components or other methylxanthines was observed. The coefficients of variation for within day and between day analysis for both saliva and plasma were less than 7.66%. Samples were collected from 20 volunteers. The correlation coefficient between plasma and saliva caffeine concentrations was found to be 0.98.
31 citations
TL;DR: Simple and sensitive spectrophotometric methods for the assay of terfenadine are described and have been successfully applied to the analysis of commercial terfenADine tablets.
24 citations
TL;DR: In this article, the response of a single-degree-of-freedom system with cubic nonlinearity to a non-stationary principal parametric excitation is investigated and two first-order ordinary-differential equations for the evolution of the amplitude and phase of the response are derived.
22 citations
TL;DR: One hundred and twenty-two donkeys from central Jordan were necropsied during the months of June, July and August 1985 and 21 showed evidence of hydatidosis, and the majority of cysts observed were non-fertile immature miliary cysts, and 10.8% were necrotic and calcified.
21 citations
TL;DR: A high‐performance liquid chromatographic method for the analysis of ranitidine in plasma and urine is described and within and between day coefficients of variation ranged from 0·79 to 2·42% and 1·09–2·95% respectively.
Abstract: Summary
A high-performance liquid chromatographic method for the analysis of ranitidine in plasma and urine is described. Plasma samples were extracted with dichloromethane while urine samples were injected directly after dilution. The mobile phase consisted of: 0·05 m ammonium acetate buffer containing 0·01 m octane sulphonate, 5·3%; methanol, 31·6%; and acetonitrile, 63·1%. Detection was carried out at 330 nm. Metoclopramide was used as the internal standard. Peak height ratios were measured. Absolute recovery from plasma was 83–85%. Within and between day coefficients of variation ranged from 0·79 to 2·42% and 1·09–2·95% respectively. Plasma and urine samples from a healthy volunteer were analysed.
19 citations
TL;DR: In this article, the interaction between ibuprofen and polyvinylpyrrolidone was studied in solution and the solid state; pH titration, conductivity measurements, solution infrared (IR) spectroscopy and solubility determination techniques were used to elucidate the mechanism of interaction in the solution state.
16 citations
TL;DR: Cincochaine was the most effective local anaesthetic with a recorded temperature of 60°C for a 99% kill while amylocaine and amethocaine showed temperatures of 84 and 90°C respectively.
Abstract: The sporicidal activity of a 1% solution of five local anaesthetics and five preservatives (cetrimide, chlorocresol, chlorhexidine, phenoxyethanol and phenylmercuric nitrate) at their commonly used concentrations, alone and in binary combinations, was determined against Bacillus subtilis and Aspergillus niger spores at different temperature levels by surface viable count technique. The sporicidal activity of all tested systems was temperature dependent and A. niger spores were much more sensitive to the effect of the test systems than B. subtilis spores. The temperatures at which 99% kill is achieved after 30 min exposure were calculated. For local anaesthetics used singly against A. niger the recorded temperatures were 30 degrees C for amethocaine, 45 degrees C for amylocaine, 43 degrees C for cincochaine, 48 degrees C and 50 degrees C for lignocaine and procaine, respectively. A control temperature of 58 degrees C for saline solution was observed. Much higher temperatures were recorded for B. subtilis spores. Cincochaine was the most effective local anaesthetic with a recorded temperature of 60 degrees C for a 99% kill while amylocaine and amethocaine showed temperatures of 84 and 90 degrees C respectively. Procaine, lignocaine as well as the control saline solution recorded temperatures higher than 100 degrees C. Among the 25 binary combinations of local anaesthetics and preservatives tested, the most pronounced potentiation of the sporicidal activity against fungal spores was recorded with chlorocresol combinations, while other combinations of the four remaining preservatives showed different types of interactions at various temperature levels.
12 citations
TL;DR: In this article, a novel approach is presented for parameterizing the class of minimum-time deadbeat controllers (MTDC) through the minimum number of parameters, based on the theory of decoupling and the properties of square decouplable systems.
Abstract: A novel approach is presented for parameterizing the class of minimum-time deadbeat controllers (MTDC) through the minimum number of parameters. The approach is based on the theory of decoupling and the properties of square decouplable systems. The main result is a compact parametric form for the class of MTDC of a discrete-time system. Contrary to many existing techniques, no special assumption on the invertibility of the transition matrix is required. >
TL;DR: In this paper, a V-trough made of plane mirrors is used as a solar concentrator with high concentration ratios assuming a normal incidence angle of solar radiation, and analytical expressions for the concentrator's length, efficiency, reflector-to-aperture ratio and ideal and actual concentration ratios are derived.
TL;DR: In this article, the disintegration and dissolution times of acetaminophen tablets were investigated and the results showed that tablet hardness, dissolution stirring rate, pH and volume of the dissolution medium influence disintegration.
TL;DR: In this paper, the pore structure of a well-hydrated portland cement (type I) of water-cement (w/c) ratios 0.3, 0.4 and 0.6 by weight was analyzed at three degrees of hydration.
Abstract: The pore structure (i.e. total pore volume, surface area and pore-size distribution curves) was measured using mercury porosimetry and nitrogen sorption. Hydrated portland cement (type I) of water-cement (w/c) ratios 0.3, 0.4 and 0.6 by weight was analyzed at three degrees of hydration (i.e., 30%, 50% and 80%; 70% for the 0.3 w/c system) corresponding to low, intermediate and high levels of hydration. The effect of curing temperature (3°, 23°, and 43°C) on pore structure was also studied. The two techniques were evaluated as well on porous Vycor glass, which has a narrow pore size distribution in the size range accessible to both. Results obtained by both techniques on porous Vycor glass agreed well. However neither technique can be used alone to study the entire pore structure in well-hydrated cement due to the wide range in pore sizes and the presence of micropores. Due to the unstable pore structure in cement a specimen treatment procedure such as methanol replacement, combined with volume-thickness (V-t) analysis, is necessary in order to measure the micropores. At low hydration values the pore structure can be estimated by mercury intrusion porosimetry (MIP). At higher hydration values, however, this technique underestimates total pore volume and surface area due to the presence of micropores which MIP cannot determine. In the pore size range of overlap, higher pore volumes were obtained with MIP. Nitrogen V-t analysis shows that micropores are more pronounced with lower w/c ratios. This finding is consistent with pore size distribution curves obtained by MIP. For a given w/c ratio and degree of hydration the total pore volume measured by MIP was found to be independent of curing temperature in the temperature range studied. At any w/c ratio, capillary porosity is controlled by degree of hydration alone.
TL;DR: In this article, a high-performance liquid chromatography method for the determination of diltiazem hydrochloride using clonazepam as internal standard is developed, where the investigated compounds were eluted from 5 u Micropak MCH-5 reversed phase column at ambient temperature with a mobile phase comprising of acetonitrile-water (48:52%) at pH 3.3.
Abstract: A rapid, selective and accurate high-performance liquid chromatography method (HPLC) for the determination of diltiazem hydrochloride using clonazepam as internal standard is developed. The investigated compounds were eluted from 5 u Micropak MCH-5 reversed phase column at ambient temperature with a mobile phase comprising of acetonitrile-water (48:52%) at pH 3.3 and containing 0. 01M sodium-n-octane sulfonate as an ion pairing substance. The mobile phase was pumped at a flow rate of 1 ml min−1 and the effluent was monitored at 239 nm. The retention times of the internal standard and diltiazem were at 3 min and 9 min, respectively. A linear relationship was derived between the peak height ratio (diltiazem/clonazepam) and diltiazem concentration over the range 1–10 μg ml−1. Detection limit for the drug is 0.2 μg ml−1 at 0.01 aufs. The developed procedure was applied to study the stability of diltiazem in the presence of its degradation products as well as in the presence of formulation excipients.
TL;DR: In this paper, the problem of designing precompensators necessary for decoupling invertible systems having weak inherent coupling is considered, and a simple algorithm, which is directly applicable to systems characterized by square proper transfer function matrices T(s), is proposed.
Abstract: The problem of designing precompensators necessary for decoupling invertible systems having weak inherent coupling is considered. A simple algorithm, which is directly applicable to systems characterized by square proper transfer function matrices T(s), is proposed for such design. In the proposed algorithm the concept ‘row reducedness at infinity’ of T(s) is utilized as an alternative, necessary and sufficient condition for the decouplability of T(s). In addition to the simple design procedure of the compensator, the algorithm yields the infinite-zero structure of both T(s) and the resulting compensated system.
TL;DR: A rapid, specific and sensitive high pressure liquid chromatographic assay for the simultaneous determination of ampicillin and cloxacillin in serum and urine is developed.
Abstract: A rapid, specific and sensitive high pressure liquid chromatographic (HPLC) assay for the simultaneous determination of ampicillin and cloxacillin in serum and urine is developed. Ampicillin, cloxacillin and cephalexin (internal standard) were eluted from a 6.5 mu Synchropack RPP reversed phase column at ambient temperature using a mobile phase comprised of methanol:water (3/7v/v) and containing 0.011 M sodium-n-octane sulphonate, 0.005 M NaH2PO4 and 1.3% v/v of 0.5 M HCl (pH 2.7). The analysis time required no longer than 11 min. Equations are presented for the linear relationships between the peak height ratios of ampicillin/cephalexin and cloxacillin/cephalexin over the range 10-80 micrograms/ml (ampicillin) and 5-25 micrograms/ml (cloxacillin), respectively. The sensitivity limits for ampicillin and cloxacillin in serum and urine were 5 micrograms/ml and 1 microgram/ml, respectively. Quality criteria such as accuracy, precision and specificity were studied extensively. We investigated the applicability of the HPLC assay for the developed simultaneous determination of the cumulative amounts of ampicillin and cloxacillin, excreted unchanged in urine after an oral dose containing 500 mg ampicillin and 500 mg cloxacillin to a human volunteer.
TL;DR: A simple, sensitive and selective high performance liquid chromatographic method for the analysis of propranolol and its major metabolite 4‐hydroxypropranolols is developed.
Abstract: Summary
A simple, sensitive and selective high performance liquid chromatographic method for the analysis of propranolol and its major metabolite 4-hydroxypropranolol is developed. The drugs and the internal standard, quinidine, were extracted from serum with ether at pH 10. The latter was evaporated and the residue was dissolved into phosphoric acid solution.
Propranolol, 4-hydroxypropranolol and quinidine were eluted from 5 μm, C-18 reversed phase column with a mobile phase consisting of acetonitrile-methanol-phosphoric acid at pH 4 and detected with fluorescence detector. Quantification was achieved by measuring the peak height ratio of each drug to the internal standard. Interference due to either biological constituents of serum or other propranolol metabolites such as n-desisopropyl propranolol and propranolol glycol was absent. The mean percentage recoveries for serum samples spiked with propranolol and 4-hydroxypropranolol were 94·7 and 98·4%, respectively. Detection limits were 10 ng/ml for propranolol and 5 ng/ml for 4-hydroxypropranolol. Within-day coefficients of variation ranged from 3·2–6·9% for propranolol and 0·8–6·2% for 4-hydroxypropranolol.
TL;DR: In this article, the design of minimum-gain minimum-time deadbeat controllers (MGMTDC) for linear discrete-time systems is considered, and a new direct method for constructing the MGMTDC of minimum Frobenius norm is developed.
Journal Article•
TL;DR: The two brands of diclofenac sodium enteric-coated tablets marketed in Jordan were found similar in weight variation and content uniformity and both met the BP requirements of disintegration for enteringic- coated tablets.
Abstract: A bioavailability study and an in vitro characterization were conducted on two brands of diclofenac sodium enteric-coated tablets marketed in Jordan. The two brands were found similar in weight variation and content uniformity and both met the BP requirements of disintegration for enteric-coated tablets. The in vitro dissolution, according to the USP XXI method, revealed that brand B had significantly faster dissolution (99% of the drug dissolved in 1 h). The bioavailability was carried out on eight healthy male volunteers who received a single dose (2 x 50 mg) of each product in a crossover design. Blood samples were obtained over a 10 h interval and drug serum concentrations were determined using a sensitive HPLC assay. The two brands did not significantly differ with respect to peak serum concentration (4.4 and 4.5 micrograms.ml-1 for A and B, respectively) or to the lag time between dosing and the appearance of the drug in serum (1.06 and 0.88 h for A and B, respectively). Further, the two brands were not found significantly different with respect to the extent of absorption as indicated by the area under serum concentration-time curve (6.31 and 5.91 micrograms.h.ml-1 for A and B, respectively). Brand B, however, exhibited a significantly earlier time to attain peak serum concentration (1.2 h) compared to brand A (2.4 h). The difference in the tmax values is consistent with the in vitro dissolution pattern for the two brands.
TL;DR: There was a marked reduction and delay in the absorption of F from seafoods and this findings should be taken into consideration when determining the optimum level of daily F intake.
Abstract: Dried seafoods are a rich source of fluoride (F). The systemic availability of F from seafoods was studied in 3 healthy adults. The plasma concentration and urinary excretion of F for 24 h following the ingestion of 3.87 +/- 0.32 mg F (mean +/- SD) in seafoods were compared with plasma and urine data following oral administration of 3 mg F in aqueous solution. There was a marked reduction and delay in the absorption of F from seafoods. The relative bioavailability of F from seafoods was 40.8 +/- 5.1%. These findings should be taken into consideration when determining the optimum level of daily F intake.
Journal Article•
TL;DR: It is concluded that there are no major differences between the three drugs in the dosage used, however, the Midazolam group showed faster recovery, more sedation, less pain on injection than the Diazepam group.
Abstract: One hundred twenty patients undergoing elective endoscopies were studied. They were allocated into three groups and accordingly they received Diazepam, Flunitrazepam and Midazolam. The effect of these drugs on the task performance of the patient's memory, anxiety and sedation level were assessed using objective tests. Cardiovascular and respiratory parameters were also assessed. All observations were subjected to student's t-test and chi squared assessment. We concluded that there are no major differences between the three drugs in the dosage used. However, the Midazolam group showed faster recovery, more sedation, less pain on injection than the Diazepam group. As for the cardiovascular system, there was a tendency for hypotension and tachycardia in all groups. Patients in the Midazolam group had more amnesia as compared to the other groups.
TL;DR: In this paper, the authors calculate the portance, de la trainee and du couple in fonction de la vitesse de rotation du cylindre tournant.
Abstract: Calcul de la portance, de la trainee et du couple en fonction de la vitesse de rotation du cylindre tournant
Patent•
20 Dec 1988TL;DR: A self-inking stamp for performing an inking upstroke comprises a base part which is adapted to be placed on the surface to be stamped and comprising an ink pad, which is opposite to the bottom surface of the base part, a type plate carrier and an actuating member, which embraces the base parts with two side legs, which are guided on the narrow side walls of the body part, and is adjusted to be displaced against spring force toward the bottom surfaces of the ink pad and the free ends of the side legs of which are interconnected by a pivot, which extends through slots formed
Abstract: A self-inking stamp for performing an inking upstroke comprises a base part, which is adapted to be placed on the surface to be stamped and comprising an ink pad, which is opposite to the bottom surface of the base part, a type plate carrier, which is disposed in the base part and adapted to be reciprocated between the ink pad and the bottom surface of the base part and to be inverted during each stroke, and an actuating member, which embraces the base part with two side legs, which are guided on the narrow side walls of the base part, and is adapted to be displaced against spring force toward the bottom surface of the base part and the free ends of the side legs of which are interconnected by a pivot, which extends through slots formed in the narrow side walls of the base part. In such stamp, the type plate carrier is pivoted on said pivot, which is formed with laterally disposed longitudinal track grooves for receiving respective guide pins, constraining straps are provided between the type plate carrier and the narrow side walls of the base part, each of said straps is formed with a cam slot, through which said pivot extends, each of said straps carries one of said guide pins adjacent to the center of said cam slot, and said constraining straps are pivoted in the narrow side walls of the base part by pivot pins disposed above the associated cam slot. In order to facilitate the assembling, the two constraining straps are interconnected by a crossbar, which extends above the ink pad, to form an integral U-shaped member, and the pivot pins are carried by tongues, which have been lanced from the constraining straps and are resilient in the axial direction of the pivot pins.
TL;DR: The accelerated stability of diltiazem in aqueous sugar solutions, with or without sodium dihydrogen phosphate, was investigated using a high‐pressure liquid chromatographic method using pseudo first‐order kinetics.
Abstract: The accelerated stability of diltiazem in aqueous sugar solutions, with or without sodium dihydrogen phosphate, was investigated using a high-pressure liquid chromatographic method. The degradation of diltiazem in all sugar solutions followed pseudo first-order kinetics. The shelf-life of diltiazem in the pure sugar solutions (0.28 M) was arranged in the following order: fructose greater than dextrose greater than sucrose = sorbitol = mannitol greater than lactose. Incorporation of 0.1 or 0.2 M sodium dihydrogen phosphate in the sugar solutions resulted in a decrease in the shelf-life of diltiazem. The reduction was most pronounced with fructose. The use of the above sugars (with the exception of lactose) would make it possible to prepare liquid dosage forms of diltiazem extemporaneously which will retain their potencies for a minimum of 50 days.
TL;DR: The urinary excretion of ampicillin in human subjects after an oral administration of 500 mg ampiculin capsules was established using the proposed HPLC method, and it proved to be advantageous as it monitors amicillin level in urine.
Abstract: A rapid, sensitive and specific HPLC assay for the determination of ampicillin in human urine is developed. Ampicillin was directly measured in human urine at 225 nm using a reversed phase column (Synchropack RP-P) and a mobile phase composed of (1:9 methanol-sodium acetate solution, 0.01 M, pH 4). The analysis required no longer than 10 min. Linear correlation between the peak height ratio of ampicillin to cefoxitin sodium (internal standard) and ampicillin concentration in urine over the range 10–100 μg ml−1 was obtained. The developed method proved to be advantageous as it monitors ampicillin level in urine. Moreover, the urinary excretion of ampicillin in human subjects after an oral administration of 500 mg ampicillin capsules was established using the proposed method.
TL;DR: The bioequivalence of six brands of cephalexin capsules or tablets was studied in six healthy volunteers in a crossover design and it was demonstrated that the six products were bioequivalent.
Abstract: The bioequivalence of six brands of cephalexin capsules or tablets was studied in six healthy volunteers in a crossover design. Single oral doses (1 X 500 mg) of each product were administered at intervals of 1 week. Bioequivalence was assessed by a urinary excretion method in which the drug was assayed by a sensitive and precise high pressure liquid chromatographic (HPLC) method. Statistical analysis of the cumulative urinary amounts of cephalexin excreted after 7 h indicated no significant differences between brand A and the other brands. However, brand C was significantly different from brands F and B. The various brands did not differ from each other with respect to urinary excretion rate, time to reach the urinary peak height, elimination rate constant and absorption rate constant. The study demonstrated that the six products of cephalexin were bioequivalent.
TL;DR: The results of 4 years of clinical studies on sheep reported to be ill owing to C. pumilum toxicity, revealed that they were actually suffering from babesiosis.
08 Jun 1988
TL;DR: A microcomputer-based generator for random-element stereograms that generates different visual stimuli is described, which allows any solid-shaped target to be programmed and varied in size or shape, movement and disparity.
Abstract: A microcomputer-based generator for random-element stereograms that generates different visual stimuli is described. The system allows any solid-shaped target to be programmed and varied in size or shape, movement and disparity. The generator creates elements on a color monitor with resolution of 750x512 pixels. Target size is dependent on overall monitor size, and programmable movement varies over a large range with three types of movement possible: sinusoidal, triangular and square wave. Both the disparity of the target and the background can be varied by seven picture elements. The entire system consists of a host computer, custom hardware for random stereogram generation, and software. The versatility of the system is demonstrated with eye movement and visual evoked response data. >
20 Apr 1988
TL;DR: The authors describe the structure and give the hardware/software implementation of a multichannel interface card which takes one slot of an IBM PC or compatible computer and enables the PC to perform the data acquisition and storage of signals to be measured.
Abstract: The authors describe the structure and give the hardware/software implementation of a multichannel interface card which takes one slot of an IBM PC or compatible computer and enables the PC to perform the data acquisition and storage of signals to be measured. Because of the flexibility of components used in building the card, the user can select, using the keyboard, several operational parameters, such as the sampling rate and number of samples to collect from every channel. Software to control card components is written in assembly language, while that for analyzing collected data is written in a high-level language. Channels work independently, and their combined sampling rate is limited mainly by the speed of the microprocessor used. >