Lahore University of Management Sciences

About: Lahore University of Management Sciences is a education organization based out in Lahore, Pakistan. It is known for research contribution in the topics: Fixed point & Metric space. The organization has 1524 authors who have published 3015 publications receiving 42665 citations. The organization is also known as: LUMS.

Frequent DNA Hypermethylation at the RASSF1A and APC Gene Loci in Prostate Cancer Patients of Pakistani Origin

Abstract: DNA methylation has emerged as a potentially robust biomarker for prostate cancer (PCa). Since DNA methylomes appear to be disease as well as population specific, we have assessed the DNA methylation status of RASSF1A, APC, and p16 (potential biomarkers of PCa) in Pakistani population. Primary prostate cancer tissues were obtained from 27 formalin-fixed paraffin-embedded blocks (FFPE) of cancer patients who underwent radical prostatectomy and transurethral resection of prostate (TURP) during 2003–2008. As controls, twenty-four benign prostatic FFPE tissues were obtained from patients who underwent TURP for benign prostatic hyperplasia during 2008. DNA was extracted, and methylation-specific PCR was used to assess the methylation status for RASSF1A, APC, and p16 gene promoters. Our results revealed that the RASSF1A promoter was hypermethylated in all the tested cancer samples but was also hypermethylated in 3 out of 24 control tissues. The APC promoter was hypermethylated in 15 out of 27 cancer samples and in none of the control samples. Strikingly, none of the samples showed methylation at the p16 promoter. Our findings suggest that RASSF1A and APC gene promoters are frequently hypermethylated in the Pakistani population and therefore have the potential to develop into universally dependable biomarkers for detecting PCa.

Dirt, foreignness, and surveillance: The shifting relations of domestic work in Pakistan:

Abstract: This article uses the site of a residential community within a gated university complex to examine a new urban wage model of domestic labor in Punjab, Pakistan. In a socio-historical context where ...

First integrals and analytical solutions of some dynamical systems

Abstract: This article investigates the first integrals and closed- form solutions of some nonlinear first-order dynamical systems from diverse areas of applied mathematics. We use the notion of artificial Hamiltonian, and we show that every first-order system of ordinary differential equations (ODEs) can be written in the form of an artificial Hamiltonian system [see Naz and Naeem (ZNA 73(4):323–330, 2018)]. One can also express the second-order ODE or system of second-order ODEs in the form of system of first-order artificial Hamiltonian system. Then the partial Hamiltonian approach is employed to compute the partial Hamiltonian operators and the corresponding first integrals. The first integrals are utilized to construct the closed-form solutions of two-stream model for tuberculosis and dengue fever, Duffing–van der Pol oscillator, nonlinear optical oscillators under parameter restrictions, nonlinear convection model and the two- dimensional galaxy model. We show that how one can apply the existing “partial Hamiltonian approach” for nonstandard Hamiltonian systems. This study provides a new way of solving the dynamical systems of first-order ODEs, second-order ODE and second-order systems of ODEs which are expressed into the artificial Hamiltonian system.

Synthesis and properties of nickel-doped nanocrystalline barium hexaferrite ceramic materials

Abstract: M-type barium hexaferrite ceramics have emerged as important materials both for technological and commercial applications. However, limited work has been reported regarding the investigation of nanocrystalline Ni-doped barium hexaferrites. In this study, nanocrystalline barium hexaferrite ceramics with the composition BaFe12−xNi x O19 (where x = 0, 0.3 and 0.5) were synthesized by sol–gel method and characterized using X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, vibrating sample magnetometer and precision impedance analyzer. All the synthesized samples had single magnetoplumbite phase having space group P63/mmc showing the successful substitution of Ni in BaFe12O19 without the formation of any impurity phase. Average grain size of undoped samples was around 120 nm which increased slightly with the addition of Ni. Saturation magnetization (Ms) and remnant magnetization (Mr) increased with the addition of Ni, however, coercivity (Hc) decreased with the increase in Ni from x = 0 to x = 0.5. Real and imaginary parts of permittivity decreased with the increasing frequency and increased with Ni content. Dielectric loss and conductivity showed slight variation with the increase in Ni concentration.

Temperature and composition dependent density of states extracted using overlapping large polaron tunnelling model in MnxCo1−xFe2O4 (x=0.25, 0.5, 0.75) nanoparticles

Abstract: We report detailed ac electrical and structural characterization of manganese cobalt ferrite nanoparticles, prepared by coprecipitation technique. X-ray diffraction (XRD) confirmed single-phase cubic spinel structure of the nanoparticles. Tetrahedral (A) and octahedral (B) group complexes were present in the spinel lattice as determined by Fourier Transform Infrared Spectroscopy (FTIR). Scanning Electron Microscope (SEM) images revealed presence of spherical shape nanoparticles having an average diameter ~50–80 nm. Composition, temperature and frequency dependent ac electrical study of prepared nanoparticles interpreted the role of cationic distribution between A and B sites. Overlapping large polaron tunnelling (OLPT) conduction mechanism was observed from 290 to 200 K. Frequency exponent s was fitted theoretically using OLPT model. High values of Density of States (DOS) of the order of 1022–1024 eV−1 cm−3 were extracted from ac conductivity for different compositions. We found that DOS was dependent on distribution of cations in the tunnel-type cavities along the a and b axis.