Institution
New York Methodist Hospital
Healthcare•Brooklyn, New York, United States•
About: New York Methodist Hospital is a healthcare organization based out in Brooklyn, New York, United States. It is known for research contribution in the topics: Myocardial infarction & Percutaneous coronary intervention. The organization has 948 authors who have published 936 publications receiving 29954 citations.
Topics: Myocardial infarction, Percutaneous coronary intervention, Population, Conventional PCI, Heart failure
Papers published on a yearly basis
Papers
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TL;DR: The HR+/HER2-breast cancer subtype has a higher rate of lymph node involvement at diagnosis than the triple-negative subtype, and may play a role in guiding regional management considerations if confirmed in further studies.
Abstract: Purpose
Breast cancer subtype correlates with response to systemic therapy and overall survival (OS), but its impact on lymphatic spread is incompletely understood. In this study, we used the Surveillance, Epidemiology, and End Results registry to assess whether the subtype can predict the presence of nodal metastasis or advanced nodal stage in breast cancer.
32 citations
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TL;DR: Pulse oximetry was not a sensitive test for detecting early PVD and the value of elevating the limb to improve the sensitivity of detection of PVD by the pulse oximeter was determined.
Abstract: The role of pulse oximetry in the evaluation of peripheral vascular disease (PVD) was investigated. In addition, the value of elevating the limb to improve the sensitivity of detection of PVD by the pulse oximeter was also determined. Pulse oximetry reading in the toes were obtained in 40 young, healthy volunteers and in 40 randomly selected patients referred to the vascular investigation laboratory over a period of two months. All 40 healthy volunteers had normal pulse oximetry readings. Normal pulse oximetry reading in the toes was defined as > 95% O2 Sat and +/-2 of finger pulse oximetry reading. In all 40 patients, pulse oximetry readings were either normal or not detected at all. Since there was no gradation in decrease in the pulse oximetry reading with severity of disease or with elevation of the patient's lower extremity, an absent or no reading was considered as an abnormal result from the test. The frequency of abnormal pulse oximetry readings increased significantly in groups with abnormal ankle-brachial pressure index (ABPI) and also varied significantly with elevation of the patients' lower limbs. In patients with no PVD detected by Doppler (ABPI > 0.9), pulse oximetry readings were normal in all. However, in patients with moderate PVD (ABPI, 0.5-0.9), 84% of the patients' lower limbs had normal pulse oximetry readings and 16% had an abnormal reading at baseline level (flat). An additional 12% of the lower limbs in this group had an abnormal reading on elevation of the limb to 12 inches. In patients with severe PVD (ABPI < 0.5), 54% of the patients' lower limbs had an abnormal reading at baseline and an additional 23% had an abnormal reading at elevation of the limb to 12 inches. In conclusion, pulse oximetry was not a sensitive test for detecting early PVD.
32 citations
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TL;DR: The 3 distinct slopes for the relation between SB-12 and MMA challenges the conventional use of one cutoff point for classifying vitamin B-12 status and would fail to separate the small, severely deficient group from the intermediate group that has neither normal nor clearly deficient vitaminB-12 concentrations.
32 citations
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TL;DR: The changes in cyclin expression combined with reduced catalytic activity of cyclin‐dependent kinases could explain in molecular terms the anti‐proliferative effect of SS on HT‐29 colon cancer cells.
Abstract: Sulindac sulfide (SS), the active metabolite of the colon cancer chemopreventive compound sulindac, inhibits the proliferation of HT-29 colon cancer cells mainly by inducing cell quiescence. We determined by bivariate flow-cytometric analysis both the DNA and cyclin protein content of individual cells. Thus, we assessed in detail the expression of several cyclins during the cell-cycle phases and demonstrated that SS (i) decreases the expression of cyclins BI and E and (ii) increases the expression of cyclins D1, D2 and D3, particularly in the G 1 phase of the cell cycle. SS-induced apoptotic cells expressed both E- and D-type cyclins but not cyclin B1. The changes in cyclin expression combined with reduced catalytic activity of cyclin-dependent kinases could explain in molecu lar terms the anti-proliferative effect of SS on HT-29 colon cancer cells. These changes may contribute to the chemopreventive effect of sulindac.
32 citations
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TL;DR: Whether there are significant differences in the assignment of ASA-PS by non-anesthesia providers when compared to anesthesia providers is investigated to determine.
31 citations
Authors
Showing all 953 results
Name | H-index | Papers | Citations |
---|---|---|---|
Manish Sharma | 82 | 1407 | 33361 |
Vic Hasselblad | 80 | 215 | 24087 |
Alan B. Lumsden | 69 | 490 | 16111 |
Kutluk Oktay | 68 | 261 | 16787 |
David J. Whellan | 60 | 269 | 16592 |
James C. Fang | 59 | 275 | 20075 |
Ralph Green | 54 | 228 | 10318 |
Sorin J. Brener | 47 | 266 | 13534 |
Ralph Carmel | 46 | 139 | 6949 |
S. Chiu Wong | 45 | 165 | 11468 |
O. Wayne Isom | 45 | 102 | 7446 |
Martin Möckel | 43 | 286 | 7630 |
Narong Kulvatunyou | 37 | 217 | 4691 |
Moshe Schein | 35 | 164 | 4528 |
Leslie Wise | 35 | 234 | 4783 |