Northwick Park Hospital

About: Northwick Park Hospital is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Blood pressure. The organization has 4387 authors who have published 4184 publications receiving 192933 citations.

The Weissenbacher-Zweymüller, Stickler, and Marshall syndromes: further evidence for their identity.

Abstract: We report on three unrelated children with neonatal radiological characteristics of the Weissenbacher-Zweymuller (W-Z) syndrome. Subsequently, they developed the Marshall syndrome. The relationship between the W-Z, Marshall, and Stickler syndromes is discussed.

Haemodynamic effects of diuretics in heart failure

Abstract: The organic mercurials have been known to have a diuretic effect since the sixteenth century, but their use for treating dropsy first began in 1920 in Vienna, when it was realised that a mercury compound being used to treat syphilis greatly increased urine output. The direct descendant of that compound was mersalyl, which was to remain the drug of choice until 1951, when the carbonic anhydrase inhibitors were introduced. One reason for the slow development of interest in the diuretics was the reluctance of the medical profession to accept that they

Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness

Abstract: Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3' region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25-2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63-5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71-4.68; P = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95% CI, 2.12-11.54; P = 0.0002). No genotype-phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. SIGNIFICANCE: Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.

The biology of schizophrenia.

Abstract: Genes may be relevant not only to predisposition but also to the type of schizophrenic illness which occur, and determine whether symptoms of the type I or type II syndromes or a combination of the two are the major manifestations. Both syndromes, howerver, might be caused by a single agent, e.g.a. virus. Thus, amongst the population of patients at risk there is a group who experience a primary neurochemical disturbance (e.g. of dopaminergic transmission). This becomes manifest in positive symptoms (delusions, hallucinations and thought disorder) and might result from an affinity of the virus for a particular neurochemical structure (e.g. the D2 dopamine receptor or a molecule concerned in its regulation). Within this population however, is a sub-group that is predisposed to a more malignant and widespread disease. In these patients the virus gains further footholds in the nervous system, with the consequence that the disease acquires the characteristics of a chronic encephalitis. It is in these cases that there is evidence of structural change (although the site of the presumed cell loss has yet to be determined) and when present this change is associated with intellectual impairment and negative symptoms (the type II syndrome). Thus the disturbance underlying the type I syndrome is a neurochemical one which accounts for the reversibility of some schizophrenic symptoms and illnesses, and their response to neuroleptic drugs. It is compatible with Bleuler's view of schizophrenia as a functional psychosis which can be clearly distinguished from dementia. The change underlying the type II syndrome is progressive and irreversible and accounts for poor long-term outcome. To this form of illness Kraepelin's term dementia praecox can be applied with the term dementia retaining its contemporary connotation of organic psychosis.