Institution
Poznan University of Medical Sciences
Education•Poznań, Poland•
About: Poznan University of Medical Sciences is a education organization based out in Poznań, Poland. It is known for research contribution in the topics: Population & Medicine. The organization has 5021 authors who have published 10098 publications receiving 145607 citations.
Topics: Population, Medicine, Cancer, Diabetes mellitus, Pregnancy
Papers published on a yearly basis
Papers
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TL;DR: The current status of potential applications of silk biomaterials in the field of oncology is reviewed with a focus on the generation of implantable, injectable and targeted drug delivery systems and the three-dimensional cancer models based on silk scaffolds for cancer research.
68 citations
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TL;DR: In this paper, the authors presented the characteristic of iodine-131, mechanism of action and mechanism of tissue damage, in accordance with the principles of radiation protection, reducing exposure to ionizing radiation should be achieved by: use of proper shieldings, organization of work, appropriate distance from the radiation source and reducing the time of exposure.
Abstract: Iodine-131 is successfully used in the treatment of hyperthyroidism and differentiated thyroid cancer. Thyroid is the critical organ for iodine. Iodine is taken up by the thyroid follicular cells. Radioactive isotope iodine-131 simultaneously emits two types of radiation: radiation beta minus (β-) used for the treatment and gamma (γ) used for diagnosis. Due to the penetration of beta particles in tissue, damaging effect of β-radiation is restricted to thyroid cells. In this article, characteristic of iodine-131, mechanism of action and mechanism of tissue damage is presented. HIGH energy γ-ray emission, contributes to the dose of both: patient's body and the personnel. In accordance with the principles of radiation protection, reducing exposure to ionizing radiation should be achieved by: use of proper shieldings, organization of work, appropriate distance from the radiation source and reducing the time of exposure. Treatment with I-131, depending on medical indications, may be carried out on stationary or outpatient basis. All activities conducted in the exposure to radiation must comply with the principles of radiation protection, in accordance with the applicable regulations, that are also presented in this article.
68 citations
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TL;DR: An update on latest advances and progress in an ongoing race to develop 52 different vaccines against SARS-CoV-2 is presented, focused on registered clinical trials that fulfill the international safety and efficacy criteria in the vaccine development.
Abstract: The global outbreak of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlighted a requirement for two pronged clinical interventions such as development of effective vaccines and acute therapeutic options for medium-to-severe stages of "coronavirus disease 2019" (COVID-19). Effective vaccines, if successfully developed, have been emphasized to become the most effective strategy in the global fight against the COVID-19 pandemic. Basic research advances in biotechnology and genetic engineering have already provided excellent progress and groundbreaking new discoveries in the field of the coronavirus biology and its epidemiology. In particular, for the vaccine development the advances in characterization of a capsid structure and identification of its antigens that can become targets for new vaccines. The development of the experimental vaccines requires a plethora of molecular techniques as well as strict compliance with safety procedures. The research and clinical data integrity, cross-validation of the results, and appropriated studies from the perspective of efficacy and potently side effects have recently become a hotly discussed topic. In this review, we present an update on latest advances and progress in an ongoing race to develop 52 different vaccines against SARS-CoV-2. Our analysis is focused on registered clinical trials (current as of November 04, 2020) that fulfill the international safety and efficacy criteria in the vaccine development. The requirements as well as benefits and risks of diverse types of SARS-CoV-2 vaccines are discussed including those containing whole-virus and live-attenuated vaccines, subunit vaccines, mRNA vaccines, DNA vaccines, live vector vaccines, and also plant-based vaccine formulation containing coronavirus-like particle (VLP). The challenges associated with the vaccine development as well as its distribution, safety and long-term effectiveness have also been highlighted and discussed.
68 citations
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TL;DR: In this paper, the authors used high resolution array comparative genomic hybridization (arrayCGH) and array based expression analysis to identify systematically homozygous deletions in laryngeal squamous cell carcinoma (LSCC) and to unravel novel putative tumor suppressor genes.
Abstract: Many classical tumor suppressor genes (TSG) were identified by delineation of bi-allelic losses called homozygous deletions. To identify systematically homozygous deletions in laryngeal squamous cell carcinoma (LSCC) and to unravel novel putative tumor suppressor genes, we screened 10 LSCC cell lines using high resolution array comparative genomic hybridization (arrayCGH) and array based expression analysis. ArrayCGH identified altogether 113 regions harboring protein coding genes that showed strong reduction in copy number indicating a potential homozygous deletion. Out of the 113 candidate regions, 22 novel homozygous deletions that affected the coding sequences of 15 genes were confirmed by multiplexPCR. Three genes were homozygously lost in two cell lines: PCDH17/PCH68, PRR20, and PTPRD. For the 15 homozygously deleted genes, four showed statistically significant downregulation of expression in LSCC cell lines as compared with normal human laryngeal controls. These were ATG7 (1/10 cell line), ZMYND11 (BS69) (1/10 cell line), PCDH17/PCH68 (9/10 cell lines), and PTPRD (7/10 cell lines). Quantitative real-time PCR was used to confirm the downregulation of the candidate genes in 10 expression array-studied cell lines and an additional cohort of cell lines; statistical significant downregulation of PCDH17/PCH68 and PTPRD was observed. In line with this also Western blot analyses demonstrated a complete absence of the PCDH17 and PTPRD proteins. Thus, expression profiling confirmed recurrent alterations of two genes identified primarily by delineation of homozygous deletions. These were PCDH17/PCH68, the protocadherin gene, and the STAT3 inhibiting receptor protein tyrosine phosphatase gene PTPRD. These genes are good candidates for novel TSG in LSCC. (C) 2010 Wiley-Liss, Inc.
67 citations
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TL;DR: This study aims to study the impact of terminations of pregnancy (TOP) on very preterm mortality in Europe and finds that terminations during pregnancy have a negative impact on survival.
67 citations
Authors
Showing all 5055 results
Name | H-index | Papers | Citations |
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Thorkild I. A. Sørensen | 114 | 747 | 60060 |
Ingrid E. Scheffer | 113 | 585 | 53463 |
Kim A. Papp | 82 | 361 | 28368 |
Carle Paul | 72 | 437 | 21426 |
Sirkka Keinänen-Kiukaanniemi | 69 | 372 | 29268 |
George R. Blumenschein | 64 | 358 | 21605 |
Janusz K. Rybakowski | 59 | 485 | 14097 |
Marie-Claude Morice | 58 | 279 | 22264 |
Joerg Lahann | 56 | 262 | 13872 |
Roman Kaliszan | 54 | 282 | 9089 |
Karl-Heinz Herzig | 54 | 321 | 12623 |
Matti Uusitupa | 54 | 123 | 34387 |
Joanna Hauser | 53 | 196 | 9860 |
Maria Siemionow | 47 | 350 | 8055 |
Sakari Reitamo | 46 | 148 | 7381 |