Institution
Poznan University of Medical Sciences
Education•Poznań, Poland•
About: Poznan University of Medical Sciences is a education organization based out in Poznań, Poland. It is known for research contribution in the topics: Population & Medicine. The organization has 5021 authors who have published 10098 publications receiving 145607 citations.
Topics: Population, Medicine, Cancer, Diabetes mellitus, Pregnancy
Papers published on a yearly basis
Papers
More filters
••
TL;DR: Researchers have found an illness-specific association of val66met BDNF polymorphism with performance on Wisconsin Card Sorting Test in bipolar mood disorder.
Abstract: Illness-specific association of val66met BDNF polymorphism with performance on Wisconsin Card Sorting Test in bipolar mood disorder
107 citations
••
TL;DR: Interactions between waterfowl and these waters that imply a negative public health impact are presented, reinforcing the need for either better water-quality indicators or for water monitoring specifically for Cryptosporidium, Giardia and microsporidia.
107 citations
••
TL;DR: The aim of the present study was to further explore the effect of resveratrol on TPA-induced signaling pathways in mouse epidermis and to compare with its dimethylether, pterostilbene, which might show higher biological activity due to its possible better bioavailability.
Abstract: Resveratrol, a phytoalexin present in grapes, has been reported to inhibit multistage mouse skin carcinogenesis. Recent studies showed that topically applied resveratrol significantly inhibited cyclooxygenase-2 (COX-2) expression and activation of nuclear factor-kappaB (NF-kappaB) induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse epidermis. The aim of the present study was to further explore the effect of resveratrol on TPA-induced signaling pathways in mouse epidermis and to compare with its dimethylether, pterostilbene. Resveratrol and pterostilbene significantly reduced activator protein 1 (AP-1) and NF-kappaB activation. In the case of AP-1, the binding of c-Jun subunit was particularly affected, while only slight effect on c-Fos binding to TPA-responsive element (AP-1 binding consensus sequence) (TRE) site was observed. Both stilbenes inhibited the activation of NF-kappaB by blocking the translocation of p65 to the nucleus and increasing the retention of IkappaBa in the cytosol. The latter might be related to decreased activity of IkappaB kinase and/or proteasome 20S. Reduced activation of transcription factors decreased the expression and activity of COX-2 and inducible nitric oxide synthase (iNOS). In most assays, pterostilbene was either equally or significantly more potent than resveratrol. Pterostilbene might show higher biological activity due to its possible better bioavailability, since substitution of hydroxy with methoxy group increases lipophilicity.
107 citations
••
Queen's University Belfast1, University Hospital of Lausanne2, Boston Children's Hospital3, University Medical Center Groningen4, University of Leicester5, Medical University of Graz6, Lund University7, Poznan University of Medical Sciences8, Health Service Executive9, University of Mainz10, Royal Victoria Infirmary11, Otto-von-Guericke University Magdeburg12, National Institute for Health and Welfare13, University of Oxford14, University of Southampton15, University of Bristol16, Ulster University17
TL;DR: By excluding TOPFA and stillbirths from GBD years of life lost (YLL) estimates, GBD underestimates the burden of disease due to congenital anomaly, and thus declining YLL over time may obscure lack of progress in primary, secondary and tertiary prevention.
Abstract: Objective To validate the estimates of Global Burden of Disease (GBD) due to congenital anomaly for Europe by comparing infant mortality data collected by EUROCAT registries with the WHO Mortality Database, and by assessing the significance of stillbirths and terminations of pregnancy for fetal anomaly (TOPFA) in the interpretation of infant mortality statistics. Design, setting and outcome measures EUROCAT is a network of congenital anomaly registries collecting data on live births, fetal deaths from 20 weeks’ gestation and TOPFA. Data from 29 registries in 19 countries were analysed for 2005–2009, and infant mortality (deaths of live births at age Results According to WHO, 17%–42% of infant mortality was attributed to congenital anomaly. In 11 EUROCAT countries, average infant mortality with congenital anomaly was 1.1 per 1000 births, with higher rates where TOPFA is illegal (Malta 3.0, Ireland 2.1). The rate of stillbirths with congenital anomaly was 0.6 per 1000. The average TOPFA prevalence was 4.6 per 1000, nearly three times more prevalent than stillbirths and infant deaths combined. TOPFA also impacted on the prevalence of postneonatal survivors with non-lethal congenital anomaly. Conclusions By excluding TOPFA and stillbirths from GBD years of life lost (YLL) estimates, GBD underestimates the burden of disease due to congenital anomaly, and thus declining YLL over time may obscure lack of progress in primary, secondary and tertiary prevention.
107 citations
••
TL;DR: The PolSenior project as mentioned in this paper examined medical, psychological and socioeconomic aspects of aging in Poland and found that self-rated health was lower in females than in males in age groups 70-84, but similar in individuals of both sexes aged 65-69 and 85 years.
107 citations
Authors
Showing all 5055 results
Name | H-index | Papers | Citations |
---|---|---|---|
Thorkild I. A. Sørensen | 114 | 747 | 60060 |
Ingrid E. Scheffer | 113 | 585 | 53463 |
Kim A. Papp | 82 | 361 | 28368 |
Carle Paul | 72 | 437 | 21426 |
Sirkka Keinänen-Kiukaanniemi | 69 | 372 | 29268 |
George R. Blumenschein | 64 | 358 | 21605 |
Janusz K. Rybakowski | 59 | 485 | 14097 |
Marie-Claude Morice | 58 | 279 | 22264 |
Joerg Lahann | 56 | 262 | 13872 |
Roman Kaliszan | 54 | 282 | 9089 |
Karl-Heinz Herzig | 54 | 321 | 12623 |
Matti Uusitupa | 54 | 123 | 34387 |
Joanna Hauser | 53 | 196 | 9860 |
Maria Siemionow | 47 | 350 | 8055 |
Sakari Reitamo | 46 | 148 | 7381 |