Institution
Presbyterian Hospital of Dallas
Healthcare•Dallas, Texas, United States•
About: Presbyterian Hospital of Dallas is a healthcare organization based out in Dallas, Texas, United States. It is known for research contribution in the topics: Blood pressure & Baroreflex. The organization has 417 authors who have published 512 publications receiving 22817 citations.
Papers published on a yearly basis
Papers
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University of Utah1, Veterans Health Administration2, National Institutes of Health3, University of Nebraska Medical Center4, Case Western Reserve University5, Indiana University6, New York University7, Cedars-Sinai Medical Center8, University of California, San Francisco9, Presbyterian Hospital of Dallas10, University of Alabama11, University of Pennsylvania12, University of Pittsburgh13, Virginia Mason Medical Center14, University of Arizona15, Northwestern University16, University of California, Los Angeles17
TL;DR: The GAIT trial as discussed by the authors evaluated the efficacy and safety of glucosamine and chondroitin sulfate as a treatment for knee pain from osteoarthritis in 1583 patients.
Abstract: Background Glucosamine and chondroitin sulfate are used to treat osteoarthritis. The multicenter, double-blind, placebo- and celecoxib-controlled Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) evaluated their efficacy and safety as a treatment for knee pain from osteoarthritis. Methods We randomly assigned 1583 patients with symptomatic knee osteoarthritis to receive 1500 mg of glucosamine daily, 1200 mg of chondroitin sulfate daily, both glucosamine and chondroitin sulfate, 200 mg of celecoxib daily, or placebo for 24 weeks. Up to 4000 mg of acetaminophen daily was allowed as rescue analgesia. Assignment was stratified according to the severity of knee pain (mild [N=1229] vs. moderate to severe [N=354]). The primary outcome measure was a 20 percent decrease in knee pain from baseline to week 24. Results The mean age of the patients was 59 years, and 64 percent were women. Overall, glucosamine and chondroitin sulfate were not significantly better than placebo in reducing knee pain by 20 perce...
1,199 citations
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TL;DR: The data suggest that spontaneous changes in V˙MCA that occur at the frequency range of 0.07-0.30 Hz are related strongly to changes in arterial pressure and, furthermore, that short-term regulation of cerebral blood flow can be modeled by a transfer function with the quality of a high-pass filter.
Abstract: To test the hypothesis that spontaneous changes in cerebral blood flow are primarily induced by changes in arterial pressure and that cerebral autoregulation is a frequency-dependent phenomenon, we measured mean arterial pressure in the finger and mean blood flow velocity in the middle cerebral artery (VMCA) during supine rest and acute hypotension induced by thigh cuff deflation in 10 healthy subjects. Transfer function gain, phase, and coherence function between changes in arterial pressure and VMCA were estimated using the Welch method. The impulse response function, calculated as the inverse Fourier transform of this transfer function, enabled the calculation of transient changes in VMCA during acute hypotension, which was compared with the directly measured change in VMCA during thigh cuff deflation. Beat-to-beat changes in VMCA occurred simultaneously with changes in arterial pressure, and the autospectrum of VMCA showed characteristics similar to arterial pressure. Transfer gain increased substantially with increasing frequency from 0.07 to 0.20 Hz in association with a gradual decrease in phase. The coherence function was > 0.5 in the frequency range of 0.07-0.30 Hz and < 0.5 at < 0.07 Hz. Furthermore, the predicted change in VMCA was similar to the measured VMCA during thigh cuff deflation. These data suggest that spontaneous changes in VMCA that occur at the frequency range of 0.07-0.30 Hz are related strongly to changes in arterial pressure and, furthermore, that short-term regulation of cerebral blood flow in response to changes in arterial pressure can be modeled by a transfer function with the quality of a high-pass filter in the frequency range of 0.07-0.30 Hz.
835 citations
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TL;DR: Etanercept is a highly effective and well tolerated treatment in patients with active ankylosing spondylitis and the safety profile of etanercept was similar to that reported in studies of patients with rheumatoid arthritis or psoriatic arthritis.
Abstract: Objective
To determine the safety and efficacy of etanercept in a multicenter, randomized, placebo-controlled, double-blind trial of adults with moderate to severe active ankylosing spondylitis (AS).
Methods
Patients (n = 277) were treated with either etanercept 25 mg (n = 138) or placebo (n = 139) subcutaneously twice weekly for 24 weeks. The primary outcome measures were the percentages of patients achieving the Assessments in Ankylosing Spondylitis 20% response (ASAS20) at weeks 12 and 24. Other outcome measures included the percentage of patients achieving higher ASAS responses, and the safety of etanercept in patients with AS. All outcome measures were assessed at 2, 4, 8, 12, and 24 weeks.
Results
Treatment with etanercept resulted in dramatic improvement. The ASAS20 was achieved by 59% of patients in the etanercept group and by 28% of patients in the placebo group (P < 0.0001) at week 12, and by 57% and 22% of patients, respectively, at week 24 (P < 0.0001). All individual ASAS components, acute-phase reactant levels, and spinal mobility measures were also significantly improved. The safety profile of etanercept was similar to that reported in studies of patients with rheumatoid arthritis or psoriatic arthritis. The only adverse events that occurred significantly more often in the etanercept group were injection-site reactions, accidental injuries, and upper respiratory tract infections.
Conclusion
Etanercept is a highly effective and well tolerated treatment in patients with active AS.
716 citations
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TL;DR: Four weeks of living high-training low improves sea-level running performance in trained runners due to altitude acclimatization and maintenance of sea- level training velocities, most likely accounting for the increase in velocity at VO2 max and MSS.
Abstract: Levine, Benjamin D., and James Stray-Gundersen.“Living high-training low”: effect of moderate-altitude acclimatization with low-altitude training on performance.J. Appl. Physiol. 83(1): 102–112, 19...
695 citations
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TL;DR: A novel approach for treatment of intractable occipital neuralgia using percutaneous peripheral nerve electrostimulation techniques is presented.
Abstract: Objective. To present a novel approach for treatment of intractable occipital neuralgia using percutaneous peripheral nerve electrostimulation techniques.
Methods. Thirteen patients underwent 17 implant procedures for medically refractory occipital neuralgia. A subcutaneous electrode placed transversely at the level of C1 across the base of the occipital nerve trunk produced paresthesias and pain relief covering the regions of occipital nerve pain
Results. With follow-up ranging from 1-½ to 6 years, 12 patients continue to report good to excellent response with greater than 50% pain control and requiring little or no additional medications. The 13th patient (first in the series) was subsequently explanted following symptom resolution.
Conclusions. In patients with medically intractable occipital neuralgia, peripheral nerve electrostimulation subcutaneously at the level of C1 appears to be a reasonable alternative to more invasive surgical procedures following failure of more conservative therapies.
483 citations
Authors
Showing all 422 results
Name | H-index | Papers | Citations |
---|---|---|---|
Benjamin D. Levine | 90 | 533 | 28311 |
Ronald G. Victor | 60 | 135 | 11446 |
Linda S. Hynan | 59 | 301 | 15722 |
William K. Cornwell | 56 | 231 | 23167 |
Craig G. Crandall | 54 | 276 | 9821 |
David W. Green | 54 | 261 | 17643 |
Rong Zhang | 52 | 223 | 8462 |
Mark Feldman | 52 | 150 | 9143 |
Ronald G. Haller | 50 | 156 | 7143 |
Armin Arbab-Zadeh | 42 | 137 | 8325 |
Jurgen A.H.R. Claassen | 40 | 176 | 5221 |
Qi Fu | 39 | 164 | 4755 |
James Stray-Gundersen | 38 | 62 | 6288 |
Thad E. Wilson | 36 | 109 | 3942 |
Tanja Taivassalo | 35 | 71 | 4816 |