United Airlines

About: United Airlines is a based out in . It is known for research contribution in the topics: Flight management system & Aircraft maintenance. The organization has 373 authors who have published 356 publications receiving 6917 citations. The organization is also known as: United Air Lines, Inc. & UA.

Using Experimental Design to Find Effective Parameter Settings for Heuristics

Abstract: In this paper, we propose a procedure, based on statistical design of experiments and gradient descent, that finds effective settings for parameters found in heuristics. We develop our procedure using four experiments. We use our procedure and a small subset of problems to find parameter settings for two new vehicle routing heuristics. We then set the parameters of each heuristic and solve 19 capacity-constrained and 15 capacity-constrained and route-length-constrained vehicle routing problems ranging in size from 50 to 483 customers. We conclude that our procedure is an effective method that deserves serious consideration by both researchers and operations research practitioners.

Adenovirus-mediated transfer of a recombinant human alpha 1-antitrypsin cDNA to human endothelial cells.

Abstract: To evaluate the feasibility of using a replication-deficient recombinant adenovirus to transfer human genes to the human endothelium, human umbilical vein endothelial cells were infected in vitro with adenovirus vectors containing the lacZ gene or a human alpha 1-antitrypsin (alpha 1AT) cDNA. After in vitro infection with the lacZ adenovirus vector, cultured endothelial cells expressed beta-galactosidase. In parallel studies with the alpha 1AT adenovirus vector, infected cells expressed human alpha 1AT transcripts, as evidenced by in situ hybridization and Northern analysis, and de novo synthesized and secreted glycosylated, functional alpha 1AT within 6 hr of infection, as shown by [35S]methionine labeling and immunoprecipitation. Quantification of the culture supernatants demonstrated 0.3-0.6 micrograms of human alpha 1AT secreted per 10(6) cells in 24 hr, for at least 14 days after adenovirus vector infection. To demonstrate the feasibility of direct transfer of genes into endothelial cells in human blood vessels, lacZ or alpha 1AT adenovirus vectors were placed in the lumen of intact human umbilical veins ex vivo. Histologic evaluation of the veins after 24 hr demonstrated transfer and expression of the lacZ gene specifically to the endothelium. alpha 1AT adenovirus infection resulted both in expression of alpha 1AT transcripts in the endothelium and in de novo synthesis and secretion of alpha 1AT. Quantification of alpha 1AT in the vein perfusates showed average levels of 13 micrograms/ml after 24 hr. These observations strongly support the feasibility of in vivo human gene transfer to the endothelium mediated by replication-deficient adenovirus vectors.

Dispatching and routing of emergency vehicles in disaster mitigation using data fusion

Abstract: The aim of this paper is to develop a robust methodology for the dispatching and routing of emergency vehicles (EVs) in a post-disaster environment with the support of data fusion. In this work, we consider an earthquake scenario with a large number of casualties needing medical attention. Given an influx of information (regarding casualties, road, traffic conditions, etc.), data are fused to provide estimates of the entities under consideration. We use this information to dispatch and route EVs to casualty pickup locations, followed by delivery to appropriate hospitals. Key factors here include patient priorities, clustering criteria, and distance. Similarly, factors affecting the dispatching of EVs from patient locations to hospitals include waiting time at hospital emergency rooms, hospital capacity, and distance. Routes must be generated for EVs by accounting for real-world road networks, existing road damage, congestion, and related issues. We develop a dispatching and routing simulation model, and utilize a case study to evaluate the performance of our proposed methodology.

SDSS-V: Pioneering Panoptic Spectroscopy

Abstract: SDSS-V will be an all-sky, multi-epoch spectroscopic survey of over six million objects. It is designed to decode the history of the Milky Way, trace the emergence of the chemical elements, reveal the inner workings of stars, and investigate the origin of planets. It will also create an integral-field spectroscopic map of the gas in the Galaxy and the Local Group that is 1,000x larger than the current state of the art and at high enough spatial resolution to reveal the self-regulation mechanisms of galactic ecosystems. SDSS-V will pioneer systematic, spectroscopic monitoring across the whole sky, revealing changes on timescales from 20 minutes to 20 years. The survey will thus track the flickers, flares, and radical transformations of the most luminous persistent objects in the universe: massive black holes growing at the centers of galaxies. The scope and flexibility of SDSS-V will be unique among extant and future spectroscopic surveys: it is all-sky, with matched survey infrastructures in both hemispheres; it provides near-IR and optical multi-object fiber spectroscopy that is rapidly reconfigurable to serve high target densities, targets of opportunity, and time-domain monitoring; and it provides optical, ultra-wide-field integral field spectroscopy. SDSS-V, with its programs anticipated to start in 2020, will be well-timed to multiply the scientific output from major space missions (e.g., TESS, Gaia, eROSITA) and ground-based projects. SDSS-V builds on the 25-year heritage of SDSS's advances in data analysis, collaboration infrastructure, and product deliverables. The project is now refining its science scope, optimizing the survey strategies, and developing new hardware that builds on the SDSS-IV infrastructure. We present here an overview of the current state of these developments as we seek to build our worldwide consortium of institutional and individual members.

The lax conjecture is true

Abstract: In 1958 Lax conjectured that hyperbolic polynomials in three variables are determinants of linear combinations of three symmetric matrices. This conjecture is equivalent to a recent observation of Helton and Vinnikov.