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Showing papers by "University of Zurich published in 2023"


Journal ArticleDOI
TL;DR: In this article , a TVP-VAR dynamic connectedness analysis was employed to identify avenues through which the collapse of the FTX exchange manifested contagion effects throughout a number of financial markets.

7 citations


Journal ArticleDOI
TL;DR: In this paper , a general decomposition of the scattering amplitudes in terms of form-factors that match to specific scenarios, such as the Standard Model Effective Field Theory (SMEFT), is provided.
Abstract: We investigate the high-$p_T$ tails of the $pp\to \ell u$ and $pp \to \ell \ell$ Drell-Yan processes as probes of New Physics in semileptonic interactions with an arbitrary flavor structure. For this purpose, we provide a general decomposition of the $2\to2$ scattering amplitudes in terms of form-factors that we match to specific scenarios, such as the Standard Model Effective Field Theory (SMEFT), including all relevant operators up to dimension-$8$, as well as ultraviolet scenarios giving rise to tree-level exchange of new bosonic mediators with masses at the TeV scale. By using the latest LHC run-II data in the monolepton ($e u$, $\mu u$, $\tau u$) and dilepton ($ee$, $\mu\mu$, $\tau\tau$, $e\mu$, $e\tau$, $\mu\tau$) production channels, we derive constraints on the SMEFT Wilson coefficients for semileptonic four-fermion and dipole operators with the most general flavor structure, as well as on all possible leptoquark models. For the SMEFT, we discuss the range of validity of the EFT description, the relevance of $\mathcal{O}(1/\Lambda^2)$ and $\mathcal{O}(1/\Lambda^4)$ truncations, the impact of $d=8$ operators and the effects of different quark-flavor alignments. Finally, as a highlight, we extract for several New Physics scenarios the combined limits from high-$p_T$ processes, electroweak pole measurements and low-energy flavor data for the $b\to c\tau u$ transition, showing the complementarity between these different observables. Our results are compiled in {\tt HighPT}, a package in {\tt Mathematica} which provides a simple way for users to extract the Drell-Yan tails likelihoods for semileptonic effective operators and for leptoquark models.

7 citations


Journal ArticleDOI
TL;DR: The most severe acute aortic dissection (AAD) as mentioned in this paper is the most common cause of death in individuals surviving the acute period of acute dissection, with high immediate mortality and substantial morbidity.

6 citations


Journal ArticleDOI
TL;DR: In this article , the authors highlight negative personal privacy and informational security outcomes that may arise from development programs currently pursued in smart cities, and illustrate the ways in which the remedies proposed so far appear insufficient from a legal or practical standpoint, and set forth a number of tactical approaches that could be used to improve them.
Abstract: This article will highlight negative personal privacy and informational security outcomes that may arise from development programs currently pursued in smart cities. It aims to illustrate the ways in which the remedies proposed so far appear insufficient from a legal or practical standpoint, and to set forth a number of tactical approaches that could be used to improve them. Cities require spatial efficiency to address rising complexities, which can only be attained through an adequately efficient exchange of information among its citizens and administrators. Unprecedented volumes of private, public, and business data can now be collected, processed, and transmitted thanks to present technology. According to the authors’ analysis of current trends in technology, data collection, legislation, and the related public acceptance in Italy and Switzerland, governments, corporations, employers, and individuals will increasingly experience hazard and damage given the ease at which tracking technologies can be abused. The study clarifies how significant data privacy and information protection are in the making of a successful smart urban community and provides insights on local Italian and Swiss policy makers’ interest about digital innovation tied to the development of data protection.

3 citations


Book ChapterDOI
01 Jan 2023
TL;DR: In this paper , the authors outline the key ideas and problems of the theorizing of teaching as discussed in selected English-language literature published over the past six decades and present a summary of theories of teaching found in the literature.
Abstract: Abstract This chapter begins by outlining the key ideas and problems of the theorizing of teaching as discussed in selected English-language literature published over the past six decades. The focus is on the value of theories of teaching and the ways theories of teaching and related terms have been defined. After creating a synthesis of the various attributes which researchers have suggested can be used for assessing the quality of theories of teaching, we discuss the process and difficulties of generating theories, and present a summary of theories of teaching found in the literature. The second part of this chapter clarifies the aims of this book, describes the sampling criteria for the selection of contributors, provides an overview of the structure of the book, and lists the questions that the contributors were asked to address.

3 citations


Journal ArticleDOI
TL;DR: This paper showed that episodic LTM contributes substantially to binding memory when the capacity of working memory is stretched to the limit by larger set sizes, suggesting a contribution of episodic long-term memory (LTM) to circumvent the WM capacity limit.

3 citations


Journal ArticleDOI
Joe Davighi1
TL;DR: In this article , a family-non-universal extension of the Standard Model is presented, where the first two families feature both quark-lepton and electroweak-flavour unification, via the $SU(4) \times Sp(4_L \times SP(4)-R$ gauge group, whereas quarklepton unification for the third family is realised a la Pati-Salam.
Abstract: We present a family-non-universal extension of the Standard Model where the the first two families feature both quark-lepton and electroweak-flavour unification, via the $SU(4) \times Sp(4)_L \times Sp(4)_R$ gauge group, whereas quark-lepton unification for the third family is realised \`a la Pati-Salam. Via staggered symmetry breaking steps, this construction offers a natural explanation for the observed hierarchical pattern of fermion masses and mixings, while providing a natural suppression for flavour-changing processes involving the first two generations. The last-but-one step in the symmetry-breaking chain is a non-universal 4321 model, characterised by a vector leptoquark naturally coupled mainly to the third generation. The stability of the Higgs sector points to a 4321$\to$SM symmetry-breaking scale around the TeV, with interesting phenomenological consequences in $B$ physics and collider processes that differ from those of other known 4321 completions.

3 citations


Journal ArticleDOI
R.U.Memetov1
TL;DR: In this article , the authors describe a space of possible measurement models in which all these models can be placed, defined by three dimensions: (a) the choice of an activation function (von-Mises or Laplace), (b) a response-selection function (variants of Luce's choice rule or of signal-detection theory), and (c) whether or not memory precision is assumed to be a constant over manipulations affecting memory.
Abstract: Several measurement models have been proposed for data from the continuous-reproduction paradigm for studying visual working memory (WM): The original mixture model (Zhang & Luck, 2008) and its extension (Bays et al., 2009); the interference measurement model (IMM; Oberauer et al., 2017), and the target confusability competition (TCC) model (Schurgin et al., 2020). This article describes a space of possible measurement models in which all these models can be placed. The space is defined by three dimensions: (a) The choice of an activation function (von-Mises or Laplace), (b) the choice of a response-selection function (variants of Luce's choice rule or of signal-detection theory), (c) and whether or not memory precision is assumed to be a constant over manipulations affecting memory. A factorial combination of these three variables generates all possible models in the model space. Fitting all models to eight data sets revealed a new model as empirically most adequate, which combines a von-Mises activation function with a signal-detection response-selection rule. The precision parameter can be treated as a constant across many experimental manipulations, though it probably varies between individuals. All modeling code and the raw data modeled are available on the OSF: https://osf.io/zwprv/ (PsycInfo Database Record (c) 2023 APA, all rights reserved).

3 citations



Book ChapterDOI
30 Mar 2023
TL;DR: The authors presented a typologically oriented monograph on morphomes, which is the term given to systematic morphological identities, usually within inflectional paradigms, that do not map onto syntactic or semantic natural classes like ‘plural’, ‘past' or ‘third-person singular’.
Abstract: Abstract This book constitutes the first typologically oriented monograph on morphomes, which is the term given to systematic morphological identities, usually within inflectional paradigms, that do not map onto syntactic or semantic natural classes like ‘plural’, ‘past’, ‘third-person singular’. Its first half addresses the theoretical and empirical challenges surrounding the identification and definition of morphomes, and surveys their links with related notions like syncretism, homophony, blocking, segmentation, economy, morphophonology, etc. It also presents the different ways in which morphomic structures have been observed to emerge, change, and disappear from a language. The second part of the book contains its core contribution: a database with 120 morphomes across 79 languages from all around the world. These structures are first presented in painstaking philological detail, and then deconstructed into logically independent axes of variation, identified in the spirit of Multivariate Typology. Statistical analysis is then undertaken to spot trends and correlations which are subsequently discussed. Various findings, relevant to both proponents and detractors of Autonomous Morphology, have emerged regarding, for example, the idiosyncratic (i.e. not representative) nature of Romance morphomes, the existence of cross-linguistically recurrent unnatural patterns, and the preference for more natural structures even among morphomes. The database is also expected to allow explorations of other issues, such as how learnability and communicative efficiency pressures impact morphological structure, and lexical and grammatical informativity across the word.

2 citations


Journal ArticleDOI
TL;DR: In this article , the total cross-section of the QCD corrections to hadronic final states in electron-positron collisions at the strong coupling constant was analyzed by separately integrating the tree-level five-parton, the one-loop four-partons, the two-loop three-partones, and the three-loop two-partone matrix elements over the respective phase space.
Abstract: We investigate the quantum chromodynamics (QCD) corrections to hadronic final states in electron-positron collisions at $\mathcal{O}(\alpha_s^3)$ in the strong coupling constant $\alpha_s$. Namely, we analytically compute the total cross section for this process by separately integrating the tree-level five-parton, the one-loop four-parton, the two-loop three-parton, and the three-loop two-parton matrix elements over the respective phase space. All the contributions to the calculation are treated in a common framework whereby phase space integrals are expressed as physical cuts of the four-loop two-point function. We check the cancellation of infrared poles at all colour levels and we reproduce the known result for the $R$-ratio at order $\alpha_s^3$.

Journal ArticleDOI
TL;DR: In this paper , an updated phenomenological analysis of the simplified $U_1$-leptoquark model addressing charged-current $B$-meson anomalies is presented, showing a good compatibility of low-energy data (dominated by the lepton flavor universality ratios $R_D$ and $R_{D^*}$) with the high-energy constraints posed by $pp\to \tau\bar\tau$ Drell-Yan data.
Abstract: In light of new data we present an updated phenomenological analysis of the simplified $U_1$-leptoquark model addressing charged-current $B$-meson anomalies. The analysis shows a good compatibility of low-energy data (dominated by the lepton flavor universality ratios $R_D$ and $R_{D^*}$) with the high-energy constraints posed by $pp\to \tau\bar\tau$ Drell-Yan data. We also show that present data are well compatible with a framework where the leptoquark couples with similar strength to both left- and right-handed third-generation fermions, a scenario that is well-motivated from a model building perspective. We find that the high-energy implications of this setup will be probed at the 95% confidence level in the high-luminosity phase of the LHC.

Journal ArticleDOI
12 Apr 2023
TL;DR: In this article , the shape of the inner ear of living squamate reptiles has been used to infer phylogenetic relationships, body size, and life habits without controlling for the effects of the other ones.
Abstract: The shape of the semicircular canals of the inner ear of living squamate reptiles has been used to infer phylogenetic relationships, body size, and life habits. Often these inferences are made without controlling for the effects of the other ones. Here we examine the semicircular canals of 94 species of extant limbed lepidosaurs using three-dimensional landmark-based geometric morphometrics, and analyze them in phylogenetic context to evaluate the relative contributions of life habit, size, and phylogeny on canal shape.Life habit is not a strong predictor of semicircular canal shape across this broad sample. Instead, phylogeny plays a major role in predicting shape, with strong phylogenetic signal in shape as well as size. Allometry has a limited role in canal shape, but inner ear size and body mass are strongly correlated.Our wide sampling across limbed squamates suggests that semicircular canal shape and size are predominantly a factor of phylogenetic relatedness. Given the small proportion of variance in semicircular canal shape explained by life habit, it is unlikely that unknown life habit could be deduced from semicircular canal shape alone. Overall, semicircular canal size is a good estimator of body length and even better for body mass in limbed squamates. Semiaquatic taxa tend to be larger and heavier than non-aquatic taxa, but once body size and phylogeny are accounted for, they are hard to distinguish from their non-aquatic relatives based on bony labyrinth shape and morphology.

Posted ContentDOI
Markus Egli1
15 May 2023
TL;DR: In this paper , the major sources of SOM in a subalpine afforestation sequence (40-130 years) with Norway spruce (Picea abies L.) on a former pasture in Jaun, Switzerland were identified.
Abstract: In alpine areas of the European Alps, many of the pastures are no longer economically profitable and are converted into forests (Bolli et al., 2007). Afforestation on former pastures affects soil organic matter (SOM) dynamics through alteration of quality and quantity of root and aboveground biomass litter input. Compared with pasture OM, forest OM is less decomposable and characterized by increased C:N ratio as well as increased lignin concentration (Hiltbrunner et al., 2013). Therefore, it could be expected that long-term afforestation on a centennial scale may have a severe impact on SOM dynamics, an aspect that remains so far unknown as most of the earlier studies focused on successions between 30 and 50 years (Vesterdal et al., 2002).In the current study, we aimed to identify the major sources of SOM in a subalpine afforestation sequence (40-130 years) with Norway spruce (Picea abies L.) on a former pasture in Jaun, Switzerland. Therefore, we combined plant- and microorganism-derived molecular proxies from several compound classes such as free-extractable fatty acids and phospholipid fatty acids.We observed a decline in soil organic carbon (SOC) stock (9.6 ± 1.1 kg m-2) after 55 years and a recovering of the SOC stock 130 years (12.7 ± 0.9 kg m-2) after afforestation. Overall, there is no alteration of the SOC stock in the mineral soil following afforestation of former pasture (13.3 ± 0.9kg m-2) after 130 years. But if we consider the additional SOC stock accumulated in the organic horizons (between 0.8 and 2 kg m-2), the total SOC stock slightly increased, although OM in organic horizons is less stabilized than mineral-bound OM. An increase of the C:N ratio in the Oi-horizon with increasing forest age (40yr: 36.9 ± 2.6; 55yr: 40.9 ± 4.1; 130yr: 42.4 ± 6.6) reflects the alteration in litter quality towards poorly decomposable compounds in older forests. In addition, preliminary results show an increase in the abundance of Gram+ (+3%) and Gram- bacteria (+6%), especially in the young (40yr) forest. Thus, the bacterial community seems to proliferate in the early succession before the fungal-dominated community takes over. Thus, the change in SOM source and quality following afforestation may not result in considerable stock changes, but results in better stability of SOM in the mineral soil.ReferencesBolli, J. C., Rigling, A., Bugmann, H. (2007). The influence of changes in climate and land-use on regeneration dynamics of Norway spruce at the treeline in the Swiss Alps. Silva Fennica, 41, 55.Hiltbrunner, D., Zimmermann, S., Hagedorn, F. (2013). Afforestation with Norway spruce on a subalpine pasture alters carbon dynamics but only moderately affects soil carbon storage. Biogeochemistry, 115, 251-266.Vesterdal, L., Ritter, E., Gundersen, P. (2002). Change in soil organic carbon following afforestation of former arable land. Forest Ecology and Management, 169, 137-147.

Journal ArticleDOI
caburghufm1
01 Apr 2023-Cortex
TL;DR: In this paper , the authors analyzed a pilot and two additional independent samples (total N = 533) of resting-state EEG from healthy young and elderly individuals and used multivariate sequential Bayesian updating of the age effect in each signal component.

Journal ArticleDOI
TL;DR: In this paper , the authors developed a theory to explain how UN peacekeepers can help overcome obstacles to democratization in conflict-affected countries, then test their theory by combining three original datasets on UN mandates, personnel, and activities covering all UN missions in Africa since the end of the Cold War.
Abstract: Does UN peacekeeping promote democracy in countries wracked by civil war? Existing studies are limited and reach contradictory conclusions. We develop a theory to explain how peacekeepers can help overcome obstacles to democratization in conflict-affected countries, then test our theory by combining three original datasets on UN mandates, personnel, and activities covering all UN missions in Africa since the end of the Cold War. Using fixed effects and instrumental variables estimators, we show that UN missions with democracy promotion mandates are strongly positively correlated with the quality of democracy in host countries but that the magnitude of the relationship is larger for civilian than for uniformed personnel, stronger when peacekeepers engage rather than bypass host governments when implementing reforms, driven in particular by UN election administration and oversight, and more robust during periods of peace than during periods of civil war.

Journal ArticleDOI
TL;DR: In this article , the role of lifelong learning in counteracting skill depreciation and obsolescence was examined in the context of job advertisement data from the Swiss job market, and the authors found that in harder occupations, with large shares of fast-depreciating hard skills, lifelong learning is primarily used as a hedge against unemployment risks rather than a boost to wages.
Abstract: This paper examines the role of lifelong learning in counteracting skill depreciation and obsolescence. We differentiate between occupations with more hard skills versus more soft skills and draw on representative job advertisement data that contain machine-learning categorized skill requirements and cover the Swiss job market in great detail across occupations (from 1950 to 2019). We examine lifelong learning effects for “harder” versus “softer” occupations, thereby analyzing the role of training in counteracting skill depreciation in occupations that are differently affected by skill depreciation. Our results reveal novel empirical patterns regarding the benefits of lifelong learning, which are consistent with theoretical explanations based on structurally different skill depreciation rates: In harder occupations, with large shares of fast-depreciating hard skills, the role of lifelong learning is primarily as a hedge against unemployment risks rather than a boost to wages. By contrast, in softer occupations, in which workers build on more value-stable soft-skill foundations, the role of lifelong learning instead lies mostly in acting as a boost for upward career mobility and leads to larger wage gains.

Journal ArticleDOI
TL;DR: In this article , an updated and optimized transformation protocol for Anthoceros agrestis was described, which can be successfully used to genetically modify one more strain of A. agresti and three more hornwort species, Anthocero punctatus, Leiosporoceros dussii, and Phaeoceros carolinianus.
Abstract: Land plants comprise two large monophyletic lineages, the vascular plants and the bryophytes, which diverged from their most recent common ancestor approximately 480 million years ago. Of the three lineages of bryophytes, only the mosses and the liverworts are systematically investigated, while the hornworts are understudied. Despite their importance for understanding fundamental questions of land plant evolution, they only recently became amenable to experimental investigation, with Anthoceros agrestis being developed as a hornwort model system. Availability of a high-quality genome assembly and a recently developed genetic transformation technique makes A. agrestis an attractive model species for hornworts. Here we describe an updated and optimized transformation protocol for A. agrestis, which can be successfully used to genetically modify one more strain of A. agrestis and three more hornwort species, Anthoceros punctatus, Leiosporoceros dussii, and Phaeoceros carolinianus. The new transformation method is less laborious, faster, and results in the generation of greatly increased numbers of transformants compared with the previous method. We have also developed a new selection marker for transformation. Finally, we report the development of a set of different cellular localization signal peptides for hornworts providing new tools to better understand the hornwort cell biology.

Journal ArticleDOI
TL;DR: In this paper , the authors investigated the ethical implications of the relaxed beliefs under psychedelics (REBUS) hypothesis, which states that patients become highly suggestible and sensitive to context during a psychedelic session, amplifying therapeutic influence and effects.
Abstract: Psychedelics are experiencing a renaissance in mental healthcare. In recent years, more and more early phase trials on psychedelic-assisted therapy have been conducted, with promising results overall. However, ethical analyses of this rediscovered form of treatment remain rare. The present paper contributes to the ethical inquiry of psychedelic-assisted therapy by analysing the ethical implications of its therapeutic mechanisms proposed by the relaxed beliefs under psychedelics (REBUS) hypothesis. In short, the REBUS hypothesis states that psychedelics make rigid beliefs revisable by increasing the influence of bottom-up input. Put differently, patients become highly suggestible and sensitive to context during a psychedelic session, amplifying therapeutic influence and effects. Due to that, patients are more vulnerable in psychedelic-assisted therapy than in other therapeutic interventions; they lose control during a psychedelic session and become dependent on the therapeutic setting (including the therapist). This enhanced vulnerability is ethically relevant and has been exploited by some therapists in the past. Therefore, patients in current research settings and starting mainstream medical settings need to be well informed about psychedelics’ mechanisms and their implications to give valid informed consent to treatment. Furthermore, other security measures are warranted to protect patients from the vulnerability coming with psychedelic-assisted therapy.

Journal ArticleDOI
TL;DR: In this paper , the authors compared primary wound closure using a suture with secondary wound healing of pin sites after removal of temporary external fixator on an upper or lower extremity at a single-center randomized controlled trial.
Abstract: The aim of this single-center randomized controlled trial was to compare primary wound closure using a suture with secondary wound healing of pin sites after removal of temporary external fixation.This noninferiority trial included all patients who were treated with a temporary external fixator on an upper or lower extremity at 1 institution. The primary outcome was pin-site infection. Secondary outcomes were measured at 2, 6, 12, 24, and 52 weeks and included all other complications, time to pin-site wound healing (in weeks), the most satisfactory pin site as rated by the patient, the visual analog scale (VAS) score for pain, and the Vancouver Scar Scale (VSS). The most proximal pin site was randomly allocated (1:1) to either primary closure or secondary wound healing, and the other pin sites were treated alternately.Seventy patients, providing 241 pin sites, were included between January 1, 2019, and March 1, 2020. A total of 123 pin sites were treated with primary closure and 118, with secondary wound healing. The median age was 55 years (interquartile range, 46 to 67 years), 44% were male, and the median duration of the external fixation was 6 days (interquartile range, 4 to 8 days). There were no pin-site infections in either group. Wound healing was significantly faster in the primary closure group (median of 2 versus 6 weeks, p = 0.013). The VSS and patient satisfaction showed no differences between groups. There was 1 case of fracture-related infection not related to any pin site.Primary closure of temporary external fixator pin sites did not result in higher infection rates compared with secondary wound healing, and pin sites healed significantly faster after primary closure. Primary closure should therefore be considered in patients treated with a temporary external fixator.Therapeutic Level I . See Instructions for Authors for a complete description of levels of evidence.

Journal ArticleDOI
TL;DR: In this paper , the authors generated further lines from ADHD patients, healthy controls using Sendai virus transduction, which may help on the study of ADHD at the molecular, cellular levels.

Journal ArticleDOI
TL;DR: In this article , the effect of test and treatment on stifle kinematics and kinetics was investigated using 3D-kinematic and kinetic data collected while performing TCT, eTPT, and iTPT and compared under the conditions of normal, CCL deficient, TPLO, and extra-articular lateral augmentation (TPLO-IB).
Abstract: Objectives To investigate stifle kinematics and kinetics following TPLO and TPLO combined with an extra-articular lateral augmentation (TPLO-IB) during the tibial compression test (TCT) and the tibial pivot compression test (TPT), applied with an external (eTPT) and an internal moment (iTPT). Study design Experimental ex vivo study. Sample population Ten cadaveric hindlimbs of dogs weighing 23–40 kg. Methods 3D-kinematic and kinetic data were collected while performing TCT, eTPT, and iTPT and compared under the conditions (1) normal, (2) CCL deficient, (3) TPLO, and (4) TPLO-IB. Two-way repeated-measures ANOVA was used to examine the effect of test and treatment on kinetic and kinematic data. Results Mean ± SD preoperative TPA was 24.7° ± 1.7°, postoperative TPA was 5.9° ± 0.7°. During TCT, there was no difference in cranial tibial translation between the intact stifle and after TPLO (p = .17). In contrast, cranial tibial translation was six times larger in TPLO compared to intact when performing eTPT and iTPT (p < .001). Cranial tibial translation with TCT, eTPT and iTPT was not different between intact stifle and TPLO-IB. Intraclass correlation coefficient for eTPT and iTPT after TPLO and TPLO-IB was excellent being 0.93 (0.70–0.99) and 0.91 (0.73–0.99), respectively. Conclusion Whereas TCT is negative after TPLO, instability persists when a rotational moment is combined using eTPT and iTPT. TPLO-IB neutralizes craniocaudal and rotational instability when performing TCT, eTPT, and iTPT.

Journal ArticleDOI
TL;DR: In this paper , the authors used multi-omics analyses to reveal that NRAS-mutated melanoma cells adopt a mesenchymal phenotype with a quiescent metabolic program to resist cellular stress induced by MEK inhibition.
Abstract: Abstract Clinical management of melanomas with NRAS mutations is challenging. Targeting MAPK signaling is only beneficial to a small subset of patients due to resistance that arises through genetic, transcriptional, and metabolic adaptation. Identification of targetable vulnerabilities in NRAS-mutated melanoma could help improve patient treatment. Here, we used multiomics analyses to reveal that NRAS-mutated melanoma cells adopt a mesenchymal phenotype with a quiescent metabolic program to resist cellular stress induced by MEK inhibition. The metabolic alterations elevated baseline reactive oxygen species (ROS) levels, leading these cells to become highly sensitive to ROS induction. In vivo xenograft experiments and single-cell RNA sequencing demonstrated that intratumor heterogeneity necessitates the combination of a ROS inducer and a MEK inhibitor to inhibit both tumor growth and metastasis. Ex vivo pharmacoscopy of 62 human metastatic melanomas confirmed that MEK inhibitor–resistant tumors significantly benefited from the combination therapy. Finally, oxidative stress response and translational suppression corresponded with ROS-inducer sensitivity in 486 cancer cell lines, independent of cancer type. These findings link transcriptional plasticity to a metabolic phenotype that can be inhibited by ROS inducers in melanoma and other cancers. Significance: Metabolic reprogramming in drug-resistant NRAS-mutated melanoma cells confers sensitivity to ROS induction, which suppresses tumor growth and metastasis in combination with MAPK pathway inhibitors.

Journal ArticleDOI
TL;DR: In this paper , the authors studied the feasible region for consecutive patterns of pattern-avoiding permutations and showed that these regions are always convex and conjecture that they are always polytopes.

Posted ContentDOI
24 Feb 2023
TL;DR: In this paper , a cost function minimization-based approach to model subselection is proposed to select sets of CMIP models based on the relative importance a user ascribes to model independence, model performance, and ensemble spread in projected climate outcome.
Abstract: Abstract. As the number of models in Coupled Model Intercomparison Project (CMIP) archives increase from generation to generation, there is a pressing need for guidance on how to interpret and best use the abundance of newly available climate information. CMIP6 users seeking to draw conclusions about model agreement must contend with an "ensemble of opportunity" containing similar models that appear under different names. Those who used CMIP5 as a basis for downstream applications must filter through hundreds of new CMIP6 simulations to find several best suited to their region, season, and climate horizon of interest. Here we present methods to address both issues, model dependence and model subselection, to help users previously anchored in CMIP5 to navigate CMIP6. In Part I, we refine a definition of model dependence based on climate output, initially employed in Climate model Weighting by Independence and Performance (ClimWIP), to designate discrete model families within CMIP5/6. We show that the increased presence of model families in CMIP6 bolsters the upper mode of the ensemble's bimodal effective Equilibrium Climate Sensitivity (ECS) distribution. Accounting for the mismatch in representation between model families and individual model runs shifts the CMIP6 ECS median and 75th percentile down by 0.43 °C, achieving better alignment with CMIP5's ECS distribution. In Part II, we present a new, cost-function minimization-based approach to model subselection, Climate model Selection by Independence, Performance, and Spread (ClimSIPS), that selects sets of CMIP models based on the relative importance a user ascribes to model independence (as defined in Part I), model performance, and ensemble spread in projected climate outcome. We demonstrate ClimSIPS by selecting sets of three to five models from CMIP5/6 for European applications, evaluating the performance from the agreement with the observed mean climate, and the spread in outcome from the projected midcentury change in surface air temperature and precipitation. To accommodate different use cases, we explore two ways to represent models with multiple members in ClimSIPS, first, by ensemble mean and second, by an individual ensemble member that maximizes midcentury change diversity within CMIP overall. Because different combinations of models are selected by the cost function for different balances of independence, performance, and spread priority, we present all selected subsets in ternary contour "subselection triangles" and guide users with recommendations based on further qualitative independence, performance, and spread standards. In CMIP6, we find that recommended subsets are populated primarily by members of several model families defined in Part I due to an inverse relationship between performance and independence. In CMIP5, recommended subsets feature model combinations used in the European branch of the Coordinated Regional Downscaling Experiment (EURO-CORDEX), suggesting the independence, performance, and spread metrics used in ClimSIPS are appropriate for European applications in CMIP6 and beyond.

Journal ArticleDOI
TL;DR: In this article , a fine-grained analysis of the dynamics of neural residuals is presented, that is, trial-by-trial variability around the mean neural population trajectory for a given task condition.
Abstract: Relating neural activity to behavior requires an understanding of how neural computations arise from the coordinated dynamics of distributed, recurrently connected neural populations. However, inferring the nature of recurrent dynamics from partial recordings of a neural circuit presents considerable challenges. Here we show that some of these challenges can be overcome by a fine-grained analysis of the dynamics of neural residuals-that is, trial-by-trial variability around the mean neural population trajectory for a given task condition. Residual dynamics in macaque prefrontal cortex (PFC) in a saccade-based perceptual decision-making task reveals recurrent dynamics that is time dependent, but consistently stable, and suggests that pronounced rotational structure in PFC trajectories during saccades is driven by inputs from upstream areas. The properties of residual dynamics restrict the possible contributions of PFC to decision-making and saccade generation and suggest a path toward fully characterizing distributed neural computations with large-scale neural recordings and targeted causal perturbations.

Posted ContentDOI
15 May 2023
TL;DR: The Marsquake Service (MQS) catalog as mentioned in this paper contains 1319 seismic events of which 6 are known meteorite impacts and 1383 superhigh frequency events that are interpreted as thermal cracking nearby the InSight lander.
Abstract: After ~4 years of deployment on the martian surface monitoring the planet&#8217;s ground motion, the InSight seismometer is now retired. Here, we review the procedures and methods the Marsquake Service (MQS) used to curate the seismic event catalog and describe the content of the catalog. The marsquake catalogue is different from normal catalogues on Earth as it aims to provide the authoritative catalog for the mission, covering the entire planet, using only a single station. As of January 1st, 2023, the MQS catalog contains 1319 seismic events of which 6 are known meteorite impacts. We have also identified 1383 superhigh frequency events that are interpreted as thermal cracking nearby the InSight lander. Late in the project large distant events occurred that allowed MQS to detect surface waves. Multiple events have been associated as impacts using orbital imaging, confirming the MQS single station location procedures. All of these new seismic phases have contributed to advance our understanding of the internal structure of Mars. The marsquake S1222a, the largest event recorded during the mission (MW 4.7) occurred in March 2022 and is also documented in our latest MQS catalog, V13, with many associated seismic phases including both Rayleigh and Love waves, their first-order overtones, and multi-orbiting surface waves that have not been identified in other marsquake records from our previous catalogues. The InSight mission is now closed but the MQS operation continues to analyze the ~4 years of seismic recordings on Mars and a final catalog, including event-specific products such as filter banks, and spectra, is in preparation. This final catalog will inform capabilities and field strategies in geophysical explorations for future martian science missions.


Journal ArticleDOI
Ke Deng1
TL;DR: This paper argued that the crucial context for Paul's metaphor of self-enslavement is not to be found in anthropological passages such as Rom 6 or Gal 5, but rather in the conditions of a slave's life in antiquity.
Abstract: Abstract Paul's reference to his adaptability to different groups in 1 Cor 9.19–23 is central to recent discussions about Paul's Jewishness. This paper argues that the crucial context for Paul's metaphor of self-enslavement (1 Cor 9.19) is not to be found in anthropological passages such as Rom 6 or Gal 5, but rather in the conditions of a slave's life in antiquity. This leads to an interpretation that combines essential concerns of a Paul within Judaism perspective with those of more traditional exegesis.

Journal ArticleDOI
TL;DR: In this article , the authors conceptualize the public sphere as a dynamic network of actors and contents that are linked with each other by communicative actions, and propose to conceptualize public spheres as dynamic networks.
Abstract: Abstract This article proposes to conceptualize the public sphere as a dynamic network of actors and contents that are linked with each other by communicative actions. This perspective allows us to theoretically derive and empirically describe the entire range of small to large network structures and their evolution over time. First, we will define the elements of these networks, which include the actors, content, communicative actions, and content relations. Based on these entities, four communicative roles (producer, recipient, curator, isolate) will be distinguished. Second, we will summarize how these actors perceive the communicative situation and how they select from behavioral options. Third, we will show how this combines with the network dynamics and outcomes that are discussed in the different lines of research. This provides not only the basis for understanding the link between the communicative actions on the micro-level and macro-level structures, but also new avenues for normative discussions.