Vertex Pharmaceuticals

About: Vertex Pharmaceuticals is a company organization based out in Boston, Massachusetts, United States. It is known for research contribution in the topics: Ivacaftor & Hepatitis C virus. The organization has 2135 authors who have published 2022 publications receiving 134750 citations. The organization is also known as: Vertex Pharmaceuticals Inc. & Vertex.

Avoiding pitfalls with chemometrics and PAT in the pharmaceutical and biotech industries

Abstract: This article is to help pharmaceutical scientists, especially those who do not specialize in chemometrics, to avoid obvious errors and pitfalls. It is also intended to inform the wider analytical community about the possibilities and the limitations of different chemometric approaches. While several of these issues can apply to the general use of chemometric tools, others are more specific to the recent increase in their use in development and manufacture of pharmaceuticals. This review covers the basics of chemometrics and critically discusses common errors and dangers encountered when uninitiated scientists apply the techniques.

Process for preparing modulators of cystic fibrosis transmembrane conductance regulator

Abstract: The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.

Therapeutic peptides: the devil is in the details.

Abstract: The next generation of peptides Pharmaceuticals may push manufacturing processes beyond their limits

Thiadiazoles or oxadiazoles and their use as inhibitors of jak protein kinase

Abstract: The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and X are each independently oxygen or sulfur; A is nitrogen, CH, C-CN, or C-(C1-3 aliphatic); and R1 and R2 are taken together to form a ring. These compounds are useful as inhibitors or JAK kinases, particularly for the treatment of an autoimmune disease, a neurodegenerative disorder, or a hematologic malignancy.