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Edmund V. Capparelli
Researcher at University of California, San Diego
Publications - 306
Citations - 12280
Edmund V. Capparelli is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Population & Pharmacokinetics. The author has an hindex of 54, co-authored 281 publications receiving 10747 citations. Previous affiliations of Edmund V. Capparelli include University of California & University of Montana.
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Journal ArticleDOI
Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system.
Scott Letendre,Jennifer Marquie-Beck,Edmund V. Capparelli,Brookie M. Best,David B. Clifford,Ann C. Collier,Benjamin B. Gelman,Justin C. McArthur,J. Allen McCutchan,Susan Morgello,David M. Simpson,Igor Grant,Ronald J. Ellis +12 more
TL;DR: Poorer penetration of ARV drugs into the CNS appears to allow continued HIV replication in the CNS as indicated by higher CSF HIV viral loads, which is probably critical in treating patients who have HIV-associated neurocognitive disorders.
Journal ArticleDOI
Ethosuximide, Valproic Acid, and Lamotrigine in Childhood Absence Epilepsy
Tracy A. Glauser,Tracy A. Glauser,Avital Cnaan,Shlomo Shinnar,Deborah Hirtz,Dennis J. Dlugos,David Masur,Peggy Clark,Edmund V. Capparelli,Peter C. Adamson +9 more
TL;DR: Ethosuximide and valproic acid are more effective than lamotrigine in the treatment of childhood absence epilepsy and are associated with fewer adverse attentional effects.
Journal ArticleDOI
Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection
Rebecca M. Lynch,Eli Boritz,Emily E. Coates,Adam DeZure,Patrick J Madden,Pamela Costner,Mary E. Enama,Sarah H. Plummer,LaSonji A. Holman,Cynthia S. Hendel,Ingelise J. Gordon,Joseph P. Casazza,Michelle Conan-Cibotti,Stephen A. Migueles,Randall Tressler,Robert T. Bailer,Adrian B. McDermott,Sandeep Narpala,Sijy O'Dell,Gideon Wolf,Jeffrey D. Lifson,Brandie A. Freemire,Robert J. Gorelick,Janardan P. Pandey,Sarumathi Mohan,Nicolas Chomont,Rémi Fromentin,Tae-Wook Chun,Anthony S. Fauci,Richard M. Schwartz,Richard A. Koup,Daniel C. Douek,Zonghui Hu,Edmund V. Capparelli,Barney S. Graham,John R. Mascola,Julie E. Ledgerwood,Vrc Study Team +37 more
TL;DR: A single infusion of mAb VRC01 significantly decreased plasma viremia and preferentially suppressed neutralization-sensitive virus strains, demonstrating the virological effect of this neutralizing antibody and highlighting the need for combination strategies to maintain virus suppression.
Journal ArticleDOI
Intravenous gamma-globulin treatment and retreatment in Kawasaki disease. US/Canadian Kawasaki Syndrome Study Group.
TL;DR: IVIG retreatment in patients who remain febrile after the first course of IVIG is now common, although the efficacy of this practice requires assessment with a randomized trial, as well as the prevalence of new coronary abnormalities in KD patients treated with IVIG and aspirin remains low.
Journal ArticleDOI
Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption
Katharine J. Bar,Michael C. Sneller,Linda Harrison,J. Shawn Justement,Edgar T. Overton,Mary E. Petrone,D. Brenda Salantes,Catherine Seamon,Benjamin Scheinfeld,Richard Kwan,Gerald H. Learn,Michael A. Proschan,Edward F. Kreider,Jana Blazkova,Mark Bardsley,Eric W. Refsland,Michael Messer,Katherine E Clarridge,Nancy B Tustin,Patrick J Madden,KaSaundra Oden,Sijy O'Dell,Bernadette Jarocki,Andrea Shiakolas,Randall Tressler,Nicole A. Doria-Rose,Robert T. Bailer,Julie E. Ledgerwood,Edmund V. Capparelli,Rebecca M. Lynch,Barney S. Graham,Susan Moir,Richard A. Koup,John R. Mascola,James A. Hoxie,Anthony S. Fauci,Pablo Tebas,Tae-Wook Chun +37 more
TL;DR: Analyses of virus populations before ART as well as before and after ART interruption showed that VRC01 exerted pressure on rebounding virus, resulting in restriction of recrudescent viruses and selection for preexisting and emerging antibody neutralization-resistant virus.